王旭;黄德玉;吴庆华;程古月;袁宗辉;

• 1:华中农业大学国家兽药残留基准实验室
• 2:长江大学生命科学学院

摘要(Abstract)：

真菌毒素是一类由真菌产生的次生代谢产物,由于其在自然界污染的普遍性和广泛的毒性作用,被给予了充分关注。从机理上入手来研究真菌毒素毒性作用的起因具有重要意义。真菌毒素根据结构分类可达400种之多,它们的机理也各有不同,但是越来越多的研究表明真菌毒素与氧化应激有重大关联。真菌毒素引起的氧化应激能引起细胞毒性作用,还参与了其他靶点的毒性反应。同时真菌毒素能干扰细胞抗氧化系统的功能,降低细胞对毒素的抵抗能力。本文主要综述了真菌毒素中与氧化应激有密切联系的几种毒素的毒性作用,重点阐述了其与氧化应激之间的关系,以期对真菌毒素的毒性机理有更进一步的认识。

关键词(KeyWords)： 真菌毒素;单端孢霉烯族毒素;黄曲霉毒素;赭曲霉毒素;伏马菌素;玉米赤霉烯酮;氧化应激

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(31572575)

作者(Author): 王旭;黄德玉;吴庆华;程古月;袁宗辉;

Email:

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