抗生素对微生物的联合与低剂量毒性研究进展Progress in Researches on Toxicity of Antibiotics in Low Dose and Mixture Exposure to Microorganisms
方淑霞;王大力;朱丽华;石恬恬;秦孟楠;林志芬;
摘要(Abstract):
目前抗生素已成为一类不可忽视的环境污染物,它在环境中呈"混合-持久-低剂量"的暴露特征。因此,研究抗生素毒性效应,特别是它的联合毒性以及低剂量下毒性兴奋效应,对抗生素污染物生态风险的评价极其重要。以抗生素联合毒性的研究进展为主线,重点概述了抗生素二元混合物的急性和慢性联合毒性研究,指出了抗生素混合物间存在相互作用,它们的联合毒性并非表现为简单的加和或独立效应,且抗生素急性-慢性联合表现出的毒性效应也存在差异;发现了不仅单一抗生素具有Hormesis效应,低剂量抗生素二元混合物也具有Hormesis作用。但目前低剂量抗生素二元混合物对微生物的毒性兴奋效应研究较少,其毒性兴奋效应的预测和评价还有待进一步完善,以期为环境中抗生素的联合生态研究和风险评价提供理论依据。
关键词(KeyWords): 抗生素;微生物;联合毒性;兴奋效应
基金项目(Foundation): 国家科技部“863”计划重大项目(No.2012AA06A304);; 同济大学污染控制与资源化研究国家重点实验室自主研究(重点)项目(PCRRY11003);; 国家自然科学面上基金(201177092,21377096);; 同济大学英才(攀登)计划(0400219287);; 中央高校基本科研业务费专项资金(0400219287)
作者(Author): 方淑霞;王大力;朱丽华;石恬恬;秦孟楠;林志芬;
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DOI:
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- TU=CA/EC50A+CB/EC50B其中CA和CB是混合体系半数抑制效应时单一污染物在混合体系中的摩尔浓度(mol·L-1);EC50A和EC50B是污染物单一污染时的半数效应浓度。