方淑霞;王大力;朱丽华;石恬恬;秦孟楠;林志芬;

• 1:同济大学环境科学与工程学院污染控制与资源化研究国家重点实验室
• 2:华中科技大学化学与化工学院

摘要(Abstract)：

目前抗生素已成为一类不可忽视的环境污染物,它在环境中呈"混合-持久-低剂量"的暴露特征。因此,研究抗生素毒性效应,特别是它的联合毒性以及低剂量下毒性兴奋效应,对抗生素污染物生态风险的评价极其重要。以抗生素联合毒性的研究进展为主线,重点概述了抗生素二元混合物的急性和慢性联合毒性研究,指出了抗生素混合物间存在相互作用,它们的联合毒性并非表现为简单的加和或独立效应,且抗生素急性-慢性联合表现出的毒性效应也存在差异;发现了不仅单一抗生素具有Hormesis效应,低剂量抗生素二元混合物也具有Hormesis作用。但目前低剂量抗生素二元混合物对微生物的毒性兴奋效应研究较少,其毒性兴奋效应的预测和评价还有待进一步完善,以期为环境中抗生素的联合生态研究和风险评价提供理论依据。

关键词(KeyWords)： 抗生素;微生物;联合毒性;兴奋效应

Abstract:

Keywords:

基金项目(Foundation): 国家科技部“863”计划重大项目(No.2012AA06A304);; 同济大学污染控制与资源化研究国家重点实验室自主研究(重点)项目(PCRRY11003);; 国家自然科学面上基金(201177092,21377096);; 同济大学英才(攀登)计划(0400219287);; 中央高校基本科研业务费专项资金(0400219287)

作者(Author): 方淑霞;王大力;朱丽华;石恬恬;秦孟楠;林志芬;

Email:

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• TU=CA/EC50A+CB/EC50B其中CA和CB是混合体系半数抑制效应时单一污染物在混合体系中的摩尔浓度(mol·L-1);EC50A和EC50B是污染物单一污染时的半数效应浓度。