纳米ZnO对鲫鱼肝脏的毒性Toxicity of Nano-ZnO on Liver of Goldfish(Carassius auratus)
刘慧;朱方伟;尹颖;郭红岩;孙媛媛;王晓蓉;
摘要(Abstract)：
鲫鱼(Carassius auratus)腹腔注射不同浓度纳米ZnO(5mg·kg-1、12.5mg·kg-1、25mg·kg-1、50mg·kg-1和125mg·kg-1,以鲫鱼体重计)14d后,研究了鲫鱼肝脏中的自由基(ROS)强度变化、氧化应激反应及其毒性机制.结果表明:纳米ZnO显著诱导鲫鱼肝脏自由基产生;自由基信号强度和脂质过氧化物(MDA)随纳米ZnO浓度的升高呈先升高后降低趋势;而还原型谷胱甘肽(GSH)含量和GSH/GSSG随纳米ZnO浓度的升高呈先降低后升高趋势;纳米ZnO的毒性主要表现在引起鲫鱼肝脏氧化损伤,其毒性机制为诱导鲫鱼肝脏产生活性氧自由基.
关键词(KeyWords)： 纳米ZnO;自由基;脂质过氧化物;超氧化物歧化酶;谷胱甘肽
基金项目(Foundation): 国家自然科学基金青年项目(No.20907020)
作者(Author): 刘慧;朱方伟;尹颖;郭红岩;孙媛媛;王晓蓉;
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