镉对血管内皮细胞损伤及其致动脉硬化的毒理学机制Damage of Cadmium to Vascular Endothelial Cells and Its Toxicity Mechanism in Atherosclerosis
詹杰;胡德奇;柳承希;魏树和;张静生;
摘要(Abstract):
采用人脐静脉内皮细胞体外培养和大鼠镉染毒实验,检测镉对人脐静脉内皮细胞和大鼠血清NO和ICAM-1分泌量,及大鼠主动脉病理改变的影响。结果表明,镉染毒可造成血管内皮细胞NO分泌量明显降低和ICAM-1分泌量明显升高,与镉染毒浓度剂量相关,体外细胞培养与活体动物实验的结果表现出一致性(P<0.05)。镉暴露可明显促进血管内皮细胞凋亡,主动脉HE染色见动脉硬化改变,各层均见较多ICAM-1阳性表达,主要存在于粥样斑块区。因此,过量镉摄入通过影响大鼠血管内皮细胞功能和结构促进动脉粥样硬化的形成。
关键词(KeyWords): 镉;动脉硬化;人脐静脉内皮细胞;大鼠
基金项目(Foundation): 国家自然科学基金面上项目(31070455;40971184);; 辽宁省自然科学基金项目(2004226010;2040278;201102224);; "十二五"国家科技支撑计划课题(2012BAC17B04);; "863"计划课题(2012AA06A202)
作者(Author): 詹杰;胡德奇;柳承希;魏树和;张静生;
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参考文献(References):
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