脱氧雪腐镰刀菌烯醇毒理作用研究进展Progress in Research of Toxicological Effects of Deoxynivalenol
伍力;尹杰;冯泽猛;何流琴;崔志杰;李铁军;印遇龙;
摘要(Abstract):
脱氧雪腐镰刀菌烯醇(DON)是人畜食品中检出率和超标率最高的一种真菌毒素。与核糖体60s亚基的肽基转移酶活性中心结合后会引发核糖体应激反应,诱导细胞凋亡等作用,对肠道、免疫系统造成破坏,并且具有遗传毒性。为今后的研究工作提供参考,笔者将从DON的毒理学机制和对机体的影响角度入手对近几年新的研究成果做综合论述。
关键词(KeyWords): 脱氧雪腐镰刀菌烯醇;细胞凋亡;免疫;致畸性
基金项目(Foundation): 国家973重点基础研究发展计划“畜禽产品中有害物质形成原理与控制途径研究“(2009CB118806);; 国家自然科学基金面上项目“假单胞菌解毒酶降解饲料中呕吐毒素的作用机制“(31072042)
作者(Author): 伍力;尹杰;冯泽猛;何流琴;崔志杰;李铁军;印遇龙;
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DOI:
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