靳非;穆景利;王冬婉;高船舟;王菊英;

• 1:国家海洋环境监测中心
• 2:大连医科大学

摘要(Abstract)：

原油毒性主要源于多环芳烃(PAHs),而烷基化多环芳烃是PAHs的主要组分,氧化衍生物是PAHs降解和代谢过程所产生的重要产物。为评估比较烷基PAHs和氧化PAHs与其母体化合物对海洋生物的毒性,本研究以菲、3-甲基菲和菲醌为研究对象,对海洋经济鱼种——红鳍东方鲀(Takifugu rubripes)幼鱼进行了肝损伤评价。结果显示,线粒体、内质网是对上述3种化合物最为敏感的细胞器;3种化合物对肝损伤的表现形式不同:1.菲导致线粒体数量增加形态改变、内质网减少纹理模糊、出现脂滴、细胞空泡化、出血,2.3-甲基菲导致内质网减少、出现脂滴、细胞空泡化、出血,3.菲醌导致线粒体和内质网水肿、出现脂滴及细胞空泡化;随化合物浓度升高,肝损伤程度加重;同一浓度下,不同化合物损伤程度也有差异,总体趋势为菲醌>3-甲基菲>菲。上述结果表明,PAHs衍生物的毒性可能强于其母体化合物;除浓度外,化合物的结构可能对其毒性有重要影响。

关键词(KeyWords)： 多环芳烃;肝毒性;超微结构;河鲀

Abstract:

Keywords:

基金项目(Foundation): 海洋公益性科研专项(201305002);; 国家海洋局北海分局渤海溢油项目(SDFZQ201411124-036);; 辽宁省海洋与渔业科研项目(201416)

作者(Author): 靳非;穆景利;王冬婉;高船舟;王菊英;

Email:

DOI:

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