仪民;仪慧兰;吴丽华;

• 1:山西大学生命科学学院
• 2:Department of Statistics
• 3: University of Missouri Columbia
• 4:太原师范学院生物系

摘要(Abstract)：

铬的工业用途很广,主要用于金属加工、电镀、制革等行业,这些行业排放的三废导致了环境铬污染,对环境生态和人体健康造成危害。为探究铬对动物的毒性作用,选择昆明种纯系小白鼠作为受试生物,研究六价铬在小鼠体内的蓄积效应及毒性。结果显示,饮用水中一定浓度的六价铬(15~70 mg·L-1)可抑制小鼠体重的正常增长,染毒30 d后,小鼠肝脏和肾脏脏器系数下降,脾脏和脑的脏器系数提高;总铬含量在心脏和脾脏中增高,其他脏器中无明显蓄积效应;铬染毒组小鼠骨髓细胞活性氧水平提高,骨髓嗜多染红细胞微核率显著增高。结果表明,通过饮水摄入六价铬可造成小鼠肝肾损伤,心脏和脾脏内铬蓄积,并通过活性氧损伤效应破坏机体的遗传稳定性。

关键词(KeyWords)： 六价铬;小鼠;脏器系数;铬蓄积;微核

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(31371868);; 山西省科技攻关项目(20120322008-02);; 山西省留学回国人员科研项目(2017-010)

作者(Author): 仪民;仪慧兰;吴丽华;

Email:

DOI:

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