全氟辛烷磺酸盐(PFOS)、全氟己烷磺酸盐(PFHS)和全氟丁烷磺酸盐(PFBS)对非洲爪蟾胚胎的发育毒性Developmental Toxicity of Perfluorooctane Sulfonate,Perfluorohexane Sulfonate and Perfluorobutane Sulfonate to Xenopus Embryos
韦荣国;苏红巧;秦占芬;
摘要(Abstract):
全氟烷基磺酸盐(PFASs)在工业生产和生活中广泛应用,某些PFASs已成为环境中普遍的污染物。鉴于对动物和人类的潜在毒性,全氟辛烷磺酸盐(PFOS)已被禁用,由一些半衰期相对较短的短链PFASs(如全氟丁烷磺酸盐,PFBS)替代。虽然四碳的PFBS和六碳的全氟己烷磺酸盐(PFHS)已经广泛使用,但目前对其毒性及其机制的了解很少。通过检测发育毒性和致畸性的非洲爪蟾胚胎致畸试验(FETAX),得到PFOS、PFHS和PFBS半致死浓度(LC50),半致畸浓度(EC50)和最小抑制生长浓度(MCIG),比较研究了3种化合物的发育毒性。结果发现,PFOS的LC50、EC50和MCIG分别为51.46、108.20和35mg·L-1。PFHS和PFBS的LC50大于100mg·L-1,对胚胎形态和生长没有明显影响。PFASs暴露引起非洲爪蟾胚胎运动行为异常。FETAX结果表明,PFOS急性发育毒性明显大于PFHS和PFBS。
关键词(KeyWords): 非洲爪蟾;全氟辛烷磺酸盐(PFOS);全氟己烷磺酸盐(PFHS);全氟丁烷磺酸盐(PFBS);发育毒性
基金项目(Foundation): “863”计划课题(2010AA065105);; 国家自然科学基金项目(21077125);; 环保公益专项(201108048)
作者(Author): 韦荣国;苏红巧;秦占芬;
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DOI:
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