韦荣国;苏红巧;秦占芬;

• 1:中国科学院生态环境研究中心环境化学和生态毒理学国家重点实验室

摘要(Abstract)：

全氟烷基磺酸盐(PFASs)在工业生产和生活中广泛应用,某些PFASs已成为环境中普遍的污染物。鉴于对动物和人类的潜在毒性,全氟辛烷磺酸盐(PFOS)已被禁用,由一些半衰期相对较短的短链PFASs(如全氟丁烷磺酸盐,PFBS)替代。虽然四碳的PFBS和六碳的全氟己烷磺酸盐(PFHS)已经广泛使用,但目前对其毒性及其机制的了解很少。通过检测发育毒性和致畸性的非洲爪蟾胚胎致畸试验(FETAX),得到PFOS、PFHS和PFBS半致死浓度(LC50),半致畸浓度(EC50)和最小抑制生长浓度(MCIG),比较研究了3种化合物的发育毒性。结果发现,PFOS的LC50、EC50和MCIG分别为51.46、108.20和35mg·L-1。PFHS和PFBS的LC50大于100mg·L-1,对胚胎形态和生长没有明显影响。PFASs暴露引起非洲爪蟾胚胎运动行为异常。FETAX结果表明,PFOS急性发育毒性明显大于PFHS和PFBS。

关键词(KeyWords)： 非洲爪蟾;全氟辛烷磺酸盐(PFOS);全氟己烷磺酸盐(PFHS);全氟丁烷磺酸盐(PFBS);发育毒性

Abstract:

Keywords:

基金项目(Foundation): “863”计划课题(2010AA065105);; 国家自然科学基金项目(21077125);; 环保公益专项(201108048)

作者(Author): 韦荣国;苏红巧;秦占芬;

Email:

DOI:

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