杨巧云;邱兴华;李克秋;李光;

• 1:天津医科大学公共卫生学院
• 2:北京大学环境科学与工程学院
• 3:天津医科大学基础医学院

摘要(Abstract)：

中国已成为全球电子垃圾的主要回收地之一,电子垃圾拆解造成的污染物人体暴露及健康效应备受关注。尤其是在粗放的拆解方式下,释放的双酚A(bisphenol A,BPA)等污染物暴露以及对拆解地区人群的健康影响是重要的科学问题。选取中国北方某电子垃圾拆解地区(即暴露地区)人群为研究对象(包括29名电子垃圾拆解从业者和24名当地居民),以40 km外无电子垃圾拆解地区的人群(N=53)作为参照。暴露地区人群尿液中BPA浓度(中值:10.7μg·g-1肌酐)显著高于参照地区人群(中值:0.66μg·g-1肌酐;P<0.01),提示电子垃圾拆解活动可能造成当地人群对BPA的高暴露。暴露地区人群的尿液8-羟基脱氧鸟苷(8-OHd G;中值:236μg·g-1肌酐)高于参照人群(中值:142μg·g-1肌酐),统计结果接近显著(P=0.055)。暴露地区人群血清中谷胱甘肽S转移酶(GSH-ST)与铜/锌-超氧化物歧化酶(Cu/Zn-SOD)含量较参照组显著降低;而谷胱甘肽过氧化物酶(GSH-Px)显著高于参照组(P<0.01)。BPA与8-OHd G显著正相关(P<0.05)、与GSH-ST负相关(P<0.01);多元回归结果显示,尿液中BPA浓度每上升1倍,8-OHd G升高34.9%(95%CI:19.4%~52.3%),而GSH-ST下降5.46%(95%CI:1.17%~9.56%)。本研究显示,电子垃圾拆解可导致该地区人群对BPA的高暴露,这种暴露可导致氧化应激包括对DNA的氧化损伤。

关键词(KeyWords)： 双酚A;氧化损伤;8-羟基脱氧鸟苷;抗氧化酶;电子垃圾拆解;健康风险

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(21322705,41421064,21190051)

作者(Author): 杨巧云;邱兴华;李克秋;李光;

Email:

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