傅相均;许洁;蒋智钢;俞捷;

• 1:遵义医科大学公共卫生学院

摘要(Abstract)：

雌激素作为一类重要的性腺类固醇化学信使,已经被证实能够直接调节机体免疫反应,因此,一些具有拟雌激素特性的环境内分泌干扰物(endocrine disruptors,EDs),会通过影响雌激素相关信号通路对免疫系统产生干扰作用。壬基酚(nonylphenol,NP)作为典型的环境内分泌干扰物,已有大量的文献报道其通过拟雌激素特性或干扰雌激素的合成、分泌、转运以及与靶点的结合,破坏机体生殖功能以及神经-免疫-内分泌系统,影响整体生理平衡与稳定。近年来,NP对免疫系统的干扰作用逐渐引起重视,研究发现,NP暴露会引起小鼠免疫器官及免疫细胞的发育异常,并且会导致新生小鼠肝毒性,肝脏细胞内炎性因子TNF-α、IL-1β分泌增加。除NP作为配体干扰雌激素信号通路外,尚未发现其他明确的分子机制解释NP造成的免疫毒性。本综述主要结合近年来相关的实验结果,总结了NP对免疫系统的潜在影响及其可能的分子机制。

关键词(KeyWords)： NP;免疫毒性;雌激素;雌激素受体

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(81560527,81760580);; 人力资源社会保障部留学人员科技活动择优资助项目(2017(08));; 贵州省科学技术基金重点项目(黔科合基础2018-1429,2019-1466);; 贵州省教育厅科技拔尖人才基金(黔教合KY2018054);; 贵州省优秀青年科技人才资助项目(黔科合平台人才[2017]5612);; 贵州省卫生计生委科学技术基金项目(gzwjkj2016-1-045,gzwjkj2017-1-053);; 遵义市“15851”人才项目经费(2019)

作者(Author): 傅相均;许洁;蒋智钢;俞捷;

Email:

DOI:

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