巩文静;朱丽岩;郝雅;江田田;韩萃;

• 1:中国海洋大学海洋生命学院
• 2:济宁医学院法医与医学检验学院

摘要(Abstract)：

为了研究四溴双酚A(tetrabromobis-phenol A,TBBPA)对海洋桡足类的急性毒性和氧化胁迫效应,以太平洋真宽水蚤为受试生物,测定了TBBPA对其96 h急性毒性和对其体内抗氧化防御系统的影响。结果表明,TBBPA对太平洋真宽水蚤的96 h半数致死浓度(96 h-LC50)为178μg·L~(-1),95%可信区间为91~306μg·L~(-1),表现为极毒。亚致死浓度下,TBBPA能够不同程度影响太平洋真宽水蚤的抗氧化防御酶活力以及非酶物质含量。其中SOD和GST活性的变化趋势较为一致,暴露初期SOD和GST活性显著上升(P<0.05),随暴露时间延长酶活性有所下降,最终趋向对照组水平;GPx活性水平始终维持在对照组以上并且差异显著(P<0.05);暴露初期,GSH含量受轻微氧化压力而轻微升高,暴露48 h后GSH含量急剧下降并显著低于对照组(P<0.05)。太平洋真宽水蚤体内SOD、GST、GPx活性和GSH含量对TBBPA暴露均十分敏感,能够为海洋环境的TBBPA监测提供生化指标参考。

关键词(KeyWords)： 四溴双酚A;太平洋真宽水蚤;急性毒性;抗氧化防御系统

Abstract:

Keywords:

基金项目(Foundation): 国家水体污染控制与治理科技重大专项(2012ZX07501-003-06);; 国家自然科学基金(31172412);国家自然科学基金(31572621)

作者(Author): 巩文静;朱丽岩;郝雅;江田田;韩萃;

Email:

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