广州地区孕妇羊水中PCBs暴露水平初步研究A Preliminary Study of PCBs Exposure Levels in Amniotic Fluid for Pregnant Women in Guangzhou
陈致远;郑铮;宋小飞;
摘要(Abstract):
随机采集广州地区非职业PCBs(polychlorinated biphenyls,多氯联苯)暴露单胎孕妇分娩时羊水,分析羊水中PCBs浓度水平;结合孕妇临床资料(年龄、孕周、身体质量指数(body mass index,BMI))以及孕妇居住环境信息等,阐明了广州地区非职业暴露孕妇羊水PCBs蓄积的影响因素。结果表明,∑33PCBs浓度为15.91-324.38 ng·g-1,平均值为114.34±83.52 ng·g-1,中值为84.8 5ng·g-1;其中十氯含量最低,平均浓度为2.66±3.46 ng·g-1,中值为1.47 ng·g-1;六氯PCBs含量最高,平均浓度为28.79±33.84 ng·g-1,中值为17.48 ng·g-1。样本中有31种PCBs同分异构体在孕妇羊水中检出,分别为PCB 8、28、30、49、52、70、74、77、82、87、99、101、105、114、118、126、128、138、153、156、158、166、169、170、179、180、183、187、189、198和209;羊水主要的PCBs暴露以五氯PCBs、六氯PCBs和七氯PCBs为主,主要的同分异构体为PCB 138(4.73%)、179(4.15%)、153(3.92%)、183(3.89%)、166(3.77%)、187(3.74%)以及180(3.67%);暴露水平与美国、西班牙、加拿大等地区相比属于严重水平。统计结果显示,年龄、身体质量指数和孕周与PCBs蓄积有显著性正相关关系;工业区居住的孕妇相与非工业区居住孕妇相比,上述统计结果更为显著。
关键词(KeyWords): 多氯联苯(PCBs);羊水;暴露水平;孕妇;广州
基金项目(Foundation): 广东省大气环境与污染控制重点实验室开放基金(2013hj003)
作者(Author): 陈致远;郑铮;宋小飞;
Email:
DOI:
参考文献(References):
- [1]胡金星,苏晓梅,韩慧波,等.固定化微生物技术修复多氯联苯污染土壤的应用前景[J].应用生态学报,2014,25(6):1806-1814Hu J X,Su X M,Han H B,et al.Application prospect about bioremediation of polychlorinated biphenyls-contaminated soil with immobilized microorganism technique:A review[J].Journal of Applied Ecology,2014,25(6):1806-1814(in Chinese)
- [2]刘明阳,刘建华,张馥,等.我国有机氯污染物污染现状及监控对策[J].环境科学与技术,2004,27(3):108-110Liu M Y,Liu J H,Zhang F,et al.Organochlorine pollutants and monitoring method in China[J].Journal of Environmental Science and Technology,2004,27(3):108-110(in Chinese)
- [3]王摆,吴金浩,于坤,等.大凌河口沉积物重金属,PCBs潜在生态风险评价[J].海洋环境科学,2014,33(4):556-561Wang B,Wu J H,Yu K,et al.Assessment of potential ecological risk for estuarine sediment heavy metals,PCBs in Darling river.[J].Journal of Marine Environmental Science,2014,33(4):556-561(in Chinese)
- [4]周玲莉,吴广龙,薛南冬,等.废旧电容器封存点土壤中的PCBs污染特征和健康风险评价[J].环境科学,2014,35(2):704-710Zhou L L,Wu G L,Xue N D,et al.Pollution patterns and health risk assessment for polychlorinated biphenyls in soils from a capacitor storage site[J].Journal of Environmental Science and Technology,2014,35(2):704-710(in Chinese)
- [5]朱智成,陈社军,丁南,等.珠三角电子垃圾和城市地区家庭灰尘中多氯联苯的来源及暴露风险[J].环境科学,2014,8:3066-3072Zhu Z C,Chen S J,Ding N,et al.Polychlorinated biphenyls in house dust at an e-waste site and urban site in the Pearl River delta,southern China:Sources and human exposure and health risks[J].Journal of Environmental Science and Technology,2014,8:3066-3072(in Chinese)
- [6]周萤,孙一鸣,雷建容,等.四川凉山藏彝青少年头发中多氯联苯污染水平的研究[J].环境科学,2015,36(1):274-279Zhou Y,Sun Y M,Lei J R,et al.Levels of polychlorinated biphenyls in Tibetan and Yi adolescents'Hair from Liangshan prefecture,Sichuan province[J].Journal of Environmental Science,2015,36(1):274-279(in Chinese)
- [7]Bradman A,Barr D B,Henn B G C,et al.Measurement of pesticides and other toxicants in amniotic fluid as a potential biomarker of prenatal exposure:Avalidation study[J].Environmental Health Perspectives,2003,111(14):1779-1782
- [8]Luzardo O P,Mahtani V,Troyano J M,et al.Determinants of organochlorine levels detectable in the amniotic fluid of women from Tenerife Island(Canary Islands,Spain)[J].Environmental Research,2009,109(5):607-613
- [9]Jarrell J,Chan S,Hauser R,et al.Longitudinal assessment of PCBs and chlorinated pesticides in pregnant women from Western Canada[J].Environmental Health,2005,4(1):10
- [10]吕全霞,李龙,余莲莲,等.台州电子垃圾循环区域母乳中多氯联苯的污染现状[J].环境化学,2014,33(10):1784-1790Lu Q X,Li L,Yu L L,et al.Polychlorinated biphenyls(PCBs)in human milk from two major electronic waste(e-waste)recycling areas in Taizhou,China[J].Journal of Environmental Chemistry,2014,33(10):1784-1790(in Chinese)
- [11]Foster W,Chan S,Platt L,et al.Detection of endocrine-disrupting chemicals in samples of second trimester human amniotic fluid[J].Journal of Clinical Endocrinology&Metabolism,2000,85(8):2954-2957
- [12]吴库生,徐锡金,刘俊晓,等.GC-MS法检测新生儿脐带血多氯联苯[J].现代预防医学,2012,39(1):119-122Wu K S,Xu X J,Liu J X,et al.Determination of polychlorinated biphenyls in umbilical cord blood by gaschromatography-mass spectrometry[J].Journal of Modern Preventive Medicine,2012,39(1):119-122(in Chinese)
- [13]周京花,马慧慧,赵美蓉,等.持久性有机污染物(POPs)生殖毒理研究进展——从实验动物生殖毒性到人类生殖健康风险[J].中国科学:化学,2013,43(3):315-325Zhou J H,Ma H H,Zhao M R,et al.Health implications of POPs on mammal and human reproduction[J].Journal of Scientia Sinica Chimica,2013,43(3):315-325(in Chinese)
- [14]屈伟月.广东省特殊人群血液和母乳中多溴联苯醚,有机氯农药和多氯联苯的初步研究[D].中国科学院研究生院(广州地球化学研究所),2007Qu W Y.Preliminary Study of Polybrominated Diphenyl Ethers,Organochlorine Pesticides and Polychlorinated Biphenyls in Human Blood and Milk of Special Populations from Guangdong Province[D].Chinese Academy of Sciences(Guangzhou Institute of Geochemistry),2007
- [15]员晓燕,杨玉义,李庆孝,等.中国淡水环境中典型持久性有机污染物(POPs)的污染现状与分布特征[J].环境化学,2013,32(011):2072-2081Yuan X Y,Yang Y Y,Li Q X,et al.Present situation and distribution characteristics of persistent organic pollutants in freshwater in China[J].Journal of Environmental Chemistry,2013,32(11):2072-2081(in Chinese)
- [16]贾可欣,麦碧娴,盛国英,等.珠江广州河段不同粒径沉积物中多氯联苯(PCBs)的分布特征[J].地球化学,2004,32(6):606-612Jia K X,Mai B X,Sheng G Y,et al.Grain-size distribution of polychlorobiphenyls in sediments of the Pearl River[J].Journal of Geochimica,2003,32(6):606-612(in Chinese)
- [17]刘国卿,刘德全,李志刚,等.深圳市大气多氯联苯的分布特征与来源[J].深圳大学学报(理工版),2014,31(4):421-427Liu G Q,Liu D Q,Li Z G,et al.Source and distribution of atmospheric polychlorinated biphenyls in Shenzhen[J].Journal of Shenzhen University(Science and Engineering),2014,31(4):421-427(in Chinese)
- [18]Glynn A W,Granath F,Aune M,et al.Organochlorines in Swedish women:Determinants of serum concentrations[J].Environmental Health Perspectives,2003,111(3):349-355
- [19]Hardell S,Tilander H,Welfinger-Smith G,et al.Levels of polychlorinated biphenyls(PCBs)and three organochlorine pesticides in fish from the Aleutian Islands of Alaska[J].PLo S one,2010,5(8):e12396
- [20]JirsováS,Maata J,Jech L,et al.Effect of polychlorinated biphenyls(PCBs)and 1,1,1-trichloro-2,2,-bis(4-chlorophenyl)-ethane(DDT)in follicular fluid on the results of in vitro fertilization-embryo transfer(IVFET)programs[J].Fertility and Sterility,2010,93(6):1831-1836
- [21]Taylor P R,Stelma J M,Lawrence C E.The relation of polychlorlnated biphenyls to birth weight and gestational age in the offspring of occupationally exposed mothers[J].American Journal of Epidemiology,1989,129(2):395-406
- [22]施召才.多氯联苯对男性生殖影响的研究[D].华南理工大学,2013Shi Z C.Study of Polychlorinated Biphenyls Effectson Male Reproductive[D].South China University of Technology,2013(in Chinese)
- [23]Govarts E,Nieuwenhuijsen M,Schoeters G,et al.Birth weight and prenatal exposure to polychlorinated biphenyls(PCBs)and dichlorodiphenyldichloroethylene(DDE):Ameta-analysis within 12 European birth cohorts[J].Environmental Health Perspectives,2012,120(2):162-170
- [24]Tsutsumi O.Assessment of human contamination of estrogenic endocrine-disrupting chemicals and their risk for human reproduction[J].The Journal of Steroid Biochemistry and Molecular Biology,2005,93(2):325-330
- [25]Schuhmacher M,Kiviranta H,Ruokojrvi P,et al.Concentrations of PCDD/Fs,PCBs and PBDEs in breast milk of women from Catalonia,Spain:Afollow-up study[J].Environment International,2009,35(3):607-613