张霖琳;谢明辉;李继华;魏复盛;吴国平;王秀琴;

• 1:中国环境监测总站
• 2:中国环境科学研究院
• 3:曲靖市疾病预防控制中心

摘要(Abstract)：

我国云南省曲靖的宣威和富源等地是全世界肺癌高发区,为了研究环境介质中铜(Cu)等重金属的暴露与体内分布特征,探讨Cu与肺癌的相关性,在当地开展肺癌环境流行病学调查,采集宣威和富源高发区人群饮食、饮水以及人体血浆和肺组织样品,微波消解ICP-MS法测定样品中Cu等元素。结果显示,当地居民使用燃料类型是影响肺癌高发的重要因素。高发区人群Cu的日摄入总量低于我国推荐的每日膳食中营养素供给量(RDA)。肺癌组血液中Cu含量显著高于对照组,肺癌组织中Cu含量显著高于癌旁组织和正常组织,且肺癌患者的血浆和肺组织中Cu/Zn比值均升高。Pearson相关性分析结果表明,Cu和Ni、Cu和Pb呈显著正相关,提示在致癌作用上具有协同效应;Cu和Fe、Cu和Zn呈显著负相关,提示具有抑制或拮抗作用。多因素Logistic回归结果表明,Cu是肺癌发生的重要影响因素,人体中Cu含量和Cu/Zn比值可为肺癌的早期预防和诊断提供科学依据。

关键词(KeyWords)： 铜;暴露;肺癌;相关性

Abstract:

Keywords:

基金项目(Foundation): 环境保护公益性行业科研专项(201309050)

作者(Author): 张霖琳;谢明辉;李继华;魏复盛;吴国平;王秀琴;

Email:

DOI:

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