云南曲靖地区铜的暴露与肺癌相关性研究Study on the Relationship between Copper Exposure and Lung Cancer in Qujing Area,Yunnan Province
张霖琳;谢明辉;李继华;魏复盛;吴国平;王秀琴;
摘要(Abstract):
我国云南省曲靖的宣威和富源等地是全世界肺癌高发区,为了研究环境介质中铜(Cu)等重金属的暴露与体内分布特征,探讨Cu与肺癌的相关性,在当地开展肺癌环境流行病学调查,采集宣威和富源高发区人群饮食、饮水以及人体血浆和肺组织样品,微波消解ICP-MS法测定样品中Cu等元素。结果显示,当地居民使用燃料类型是影响肺癌高发的重要因素。高发区人群Cu的日摄入总量低于我国推荐的每日膳食中营养素供给量(RDA)。肺癌组血液中Cu含量显著高于对照组,肺癌组织中Cu含量显著高于癌旁组织和正常组织,且肺癌患者的血浆和肺组织中Cu/Zn比值均升高。Pearson相关性分析结果表明,Cu和Ni、Cu和Pb呈显著正相关,提示在致癌作用上具有协同效应;Cu和Fe、Cu和Zn呈显著负相关,提示具有抑制或拮抗作用。多因素Logistic回归结果表明,Cu是肺癌发生的重要影响因素,人体中Cu含量和Cu/Zn比值可为肺癌的早期预防和诊断提供科学依据。
关键词(KeyWords): 铜;暴露;肺癌;相关性
基金项目(Foundation): 环境保护公益性行业科研专项(201309050)
作者(Author): 张霖琳;谢明辉;李继华;魏复盛;吴国平;王秀琴;
Email:
DOI:
参考文献(References):
- [1]全国肿瘤防治研究办公室,全国肿瘤登记中心,卫生部疾病预防控制局.中国肿瘤死亡报告:全国第三次死因回顾抽样调查[M].北京:人民卫生出版社出版社,2010:24-36
- [2]Mumford J L,He X Z,Chapman R S,et al.Lung cancer and indoor air pollution in XuanWei,China[J].Science,1987,235(9):217-220
- [3]Mumford J L,Harris D B,Williams K,et al.Indoor air sampling and mutagenicity studies of emissions from unvented coal combustion[J].Environmental Science and Technology,1987,21(3):308-311
- [4]吕俊岗,张霖琳,许人骥,等.云南省宣威市和富源县空气和土壤中多环芳烃污染水平研究[J].中国环境监测,2010,260):1-6Lv J G,Zhang L L,Xu R J,et al.Assessment of Polycyclic Aromatic Hydrocarbons(PAHs)level in Xuanwei and Fuyuan,Yunnan Province[J].Environmental Monitoring in China,2010,26(3):1-6(in Chinese)
- [5]Lan Q,Chen W,Chen H,et al.Risk factors for lung cancer in non-smoker in Xuanwei County of China[J].Biomedical and Environmental Sciences,1993,6:112-118
- [6]Lan Q,Chapman R S,Schreinemachers D M,et al.Household stove improvement and risk of lung cancer in Xuan Wei,China[J].Journal of the National Cancer Institute,2002,94(11):826-835
- [7]Liu Z Y,He X Z,Chapman R S.Smoking and other risk factors for lung cancer in Xuanwei,China[J].International Journal of Epidemiology,1999,120(1):26-31
- [8]Lan Q,He X Z,Costa D J,et al.Indoor coal combustion emissions、GSTM1 and GSTT1 genotypes,and lung cancer risk:A case-control study in Xuan Wei,China[J].Cancer Epidemiology Biomarkers and Prevention,2000,9:605-608
- [9]颜世铭,吴敬炳,徐德扬,等.微量元素导论[M].上海:同济大学出版社,1992:256-257
- [10]郁宝铭,王敏,许叔祥,等.大肠癌患者硒与免疫功能关系的研究[J].中华外科杂志,1996,35:50-51Yu B M,Wang M,Xu S X,et al.The relationship between selenium and immunity in large bowel cancer[J].Chinese Journal of Surgery,1996,35:50-51(in Chinese)
- [11]Zhang L L,Lv J G.Dietary exposure estimates of 14trace elements in Xuanwei and Fuyuan,two high lung cancer incidence areas in China[J].Biological Trace Element Research,2011,146(3):282-292
- [12]张霖琳,邢小茹,吴国平,等.微波消解-ICP-MS测定人体血浆中30种痕量元素[J].光谱学与光谱分析,2009,29(4):1115-1118Zhang L L,Xing X R,Wu G P,et al.Determination of thirty trace elements in human plasma by microwave digestion-ICP-MS[J].Spectroscopy and Spectral Analysis,2009,29(4):1115-1118(in Chinese)
- [13]张霖琳,马千里,黄云超,等.微波消解-ICP-MS法测定肺癌患者肺组织中33种元素[J].光谱学与光谱分析,2009,29(12):3388-3391Zhang L L,Ma Q L,Huang Y C,et al.Determination of thirty-three elements in lung cancer tissues of patients with lung cancer by microwave digestion-ICP-MS[J].Spectroscopy and Spectral Analysis,2009,29(12):3388-3391(in Chinese)
- [14]李继华,张云生,李云,等.云南省富源县2002-2004年肿瘤发病分析[J].环境与职业医学,2008,25(6):515-519Li J H,Zhang Y S,Li Y,et al.An analysis of lung cancer incidence in Fuyuan County,Yunnan Province during 2002-2004[J].Journal of Environmental&Occupational Medicine,2008,25(6):515-519(in Chinese)
- [15]Matakidou A,Eisen T,Houlston R S.Systematic review of the relationship between family history and lung cancer risk[J].British Journal of Cancer,2005,93(7):825-833
- [16]Jin Y T,Xu Y C,He X Z,et al.Familial aggregation of lung cancer in a high incidence area in China[J].British Journal of Cancer,2005,92(7):1321-1325
- [17]李继华,张云生,李云,等.云滇东产(燃)煤区农民肺癌流行病学调查[J].中国肺癌杂志,2011,14(2):107-119Li J H,Zhang Y S,Li Y,et al.Descriptive study on the epidemiology of lung cancer in coal-producing area in Eastern Yunnan,China[J].Chinese Journal of Lung Cancer,2011,14(2):107-119(in Chinese)
- [18]中华人民共和国卫生部.GB 5749-2006生活饮用水卫生标准[S].北京:中国标准出版社,2006
- [19]中国营养学会.中国居民膳食营养素参考摄入量[J].营养学报,2011,23(3):193-196Chinese Nutrition Society.Chinese dietary reference in takes,DRIs[J].Acta Nutrimenta Sinica,2011,23(3):193-196(in Chinese)
- [20]宋娟娥,梁月琴,于水.电感耦合等离子体质谱法测定人血浆中20种微量元素[J].分析化学,2007,35(3):423-426Song J E,Liang Y Q,Yu S.Inductively coupled plasma mass spectrometry for the simultaneous determination of 20 trace elements in human plasma samples[J].Chinese Journal of Analytical Chemistry,2007,35(3):423-426(in Chinese)
- [21]张颖,李秀.微量元素铜锌硒与肺癌的关系探讨[J].微量元素与健康研究,2000,17(3):15-17Zhang Y,Li X.Study on the relationship between trace elements copper,zinc,selenium and lung cancer[J].Studies of Trace Elements and Health,2000,17(3):15-17(in Chinese)
- [22]张霖琳,吴国平,李继华,等.女性肺癌与非癌症人群血浆中30种元素的比较分析[J].卫生研究,2009,38(1):28-31Zhang L L,Wu G P,Li J H,et al.Analysis of the contents of thirty trace elements in the plasma samples of women with lung cancer and control population[J].Journal of Hygiene Research,2009,38(1):28-31(in Chinese)
- [23]Zhang L L,Lv J G,Sun S K.Elements in lung tissues of patients from a high lung cancer incidence area of China[J].Biological Trace Element Research,2012,148(1):7-10
- [24]谢森有,陈银侠.肺癌与微量元素铜、锌关系64例分析[J].陕西医学杂志,2000,29(2):83-84Xie S Y,Chen Y X.Analysis of the relationship between trace element copper and zinc and lung cancer of 64 cases[J].Shaanxi Medical Journal,2000,29(2):83-84(in Chinese)
- [25]何兴舟,蓝青,杨儒道,等.宣威肺癌危险因素研究概述(1979-1993)[J].卫生研究,1995,24(4):203-206He X Z,Lan Q,Yang R D,et al.An overview of studies on risk factors for lung cancer in Xuanwei,China[J].Journal of Hygiene Research,1995,24(4):203-206(in Chinese)
- [26]王三根.微量元素与健康[M].上海:上海科学普及出版社,2004:121-122
- [27]段励夫.微量元素对肺癌的诊断价值[J].中国误诊学杂志,2004,4(3):395-396Duan L F.The diagnosis of trace elements affect to lung cancer[J].Chinese Journal of Misdiagnoses,2004,4(3):395-396(in Chinese)
- [28]White M A,Sabbioni E.Trace element reference values in tissues from inhabitants of the European Union.X.A study of 13 elements in blood and urine of a United Kingdom population[J].The Science of the Total Environment.1998,216:253-270
- [29]Reddy S B,Charles M J,Raju G J,et al.Trace elemental analysis of carcinoma kidney and stomach by PXIE method[J].Nuclear Instruments and Methods in Physics Research,2003,207(3):345-355
- [30]Majewska U,Banas D,Braziewicz J,et al.Trace element concentration distributions in breast,lung and colon tissues[J].Physics in Medicine and Biology,2007,52(13):3895-3911
- [31]胡振华,任群,郭建,等.血清锌、铜与铜/锌比值对肺癌诊断、疗效和预后判断的临床意义[J].广东微元素科学,2000,7(1):19-22Hu Z H,Ren Q,Guo J,et al.Significance of eetermination of serum Zinc,Copper and Copper/Zinc ratio on evaluating diagnosis therapeutic effect and prognosis of lung cancer[J].Guangdong Trace Elements Science,2000,7(1):19-22(in Chinese)