高礼;袁涛;王文华;

• 1:上海交通大学环境科学与工程学院
• 2:宁夏大学资源环境学院

摘要(Abstract)：

有机紫外防晒剂被广泛添加在个人护理品中,随着日常使用源源不断地进入环境中,成为一类新兴污染物。环境介质中有机紫外防晒剂的检测及其生态毒理是目前的研究热点。概述了个人护理品中常用的有机紫外防晒剂,总结了有机紫外防晒剂在各类地表水、沉积物和生物体等不同介质中的浓度水平,详细分析了有机紫外防晒剂对鱼类的内分泌干扰效应和对水生无脊椎动物的急性毒性,为今后深入研究和科学评价这类新兴污染物提供重要参考。

关键词(KeyWords)： 有机紫外防晒剂;环境浓度;生态毒性;内分泌干扰

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(21277092,30970531);; 上海市教育委员会科研创新重点项目(12ZZ027);; 上海市公共卫生重点学科建设项目(12GWZX0401)

作者(Author): 高礼;袁涛;王文华;

Email:

参考文献(References)：

• [1]Rodil R,Moeder M.Development of a method for the determination of UV filters in water samples u-sing stir bar sorptive extraction and thermal desorp-tion-gas chromatography-mass spectrometry[J].Journal of Chromatography A,2008,1179(2):81-88
• [2]中华人民共和国卫生部.化妆品卫生规范[S].北京:中国标准出版社,2007
• [3]Vosough M,Mojdehi N R.Fast liquid chromatogra-phy-diode array detection assisted by chemometrics for quantification of seven ultraviolet filters in efflu-ent wastewater[J].Talanta,2011,85(4):2175-2181
• [4]Li W H,Ma Y M,Guo C S,et al.Occurrence and behavior of four of the most used sunscreen UV fil-ters in a wastewater reclamation plant[J].Water Research,2007,41(15):3506-3512
• [5]Kupper T,Plagellat C,Braendli R C,et al.Fate and removal of polycyclic musks,UV filters and biocides during wastewater treatment[J].Water Research,2006,40(14):2603-2612
• [6]Liu Y S,Ying G G,Shareef A,et al.Occurrence and removal of benzotriazoles and ultraviolet filters in a municipal wastewater treatment plant[J].Envi-ronmental Pollution,2012,165(6):225-232
• [7]Balmer M E,Buser H R,Muller M D,et al.Occur-rence of some organic UV filters in wastewater,in surface waters,and in fish from Swiss lakes[J].En-vironmental Science&Technology,2005,39(4):953-962
• [8]Negreira N,Rodriguez I,Rubi E,et al.Optimizationof pressurized liquid extraction and purification condi-tions for gas chromatography-mass spectrometry de-termination of UV filters in sludge[J].Journal of Chromatography A,2011,1218(2):211-217
• [9]Liu Y S,Ying G G,Shareef A,et al.Simultaneous determination of benzotriazoles and ultraviolet filters in ground water,effluent and biosolid samples using gas chromatography-tandem mass spectrometry[J].Journal of Chromatography A,2011,1218(31):5328-5335
• [10]Fent K,Zenker A,Rapp M.Widespread occurrence of estrogenic UV-filters in aquatic ecosystems in Switzerland[J].Environmental Pollution,2010,158(5):1817-1824
• [11]Negreira N,Rodriguez I,Rubi E,et al.Dispersive liquid-liquid microextraction followed by gas chroma-tography-mass spectrometry for the rapid and sensi-tive determination of UV filters in environmental wa-ter samples[J].Analytical and Bioanalytical Chemis-try,2010,398(2):995-1004
• [12]Roman I P,Chisvert A,Canals A.Dispersive solid-phase extraction based on oleic acid-coated magnetic nanoparticles followed by gas chromatography-mass spectrometry for UV-filter determination in water samples[J].Journal of Chromatography A,2011,1218(18):2467-2475
• [13]Kameda Y,Kimura K,Miyazaki M.Occurrence and profiles of organic sun-blocking agents in surface wa-ters and sediments in Japanese rivers and lakes[J].Environmental Pollution,2011,159(6):1570-1576
• [14]Rodil R,Schrader S,Moeder M.Non-porous mem-brane-assisted liquid-liquid extraction of UV filter compounds from water samples[J].Journal of Chro-matography A,2009,1216(24):4887-4894
• [15]Moeder M,Schrader S,Winkler U,et al.At-line microextraction by packed sorbent-gas chromatogra-phy-mass spectrometry for the determination of UV filter and polycyclic musk compounds in water sam-ples[J].Journal of Chromatography A,2010,1217(17):2925-2932
• [16]Nguyen K T,Scapolla C,Di Carro M,et al.Rapid and selective determination of UV filters in seawater by liquid chromatography-tandem mass spectrometry combined with stir bar sorptive extraction[J].Ta-lanta,2011,85(5):2375-2384
• [17]Tarazona I,Chisvert A,Leon Z,et al.Determina-tion of hydroxylated benzophenone UV filters in sea water samples by dispersive liquid-liquid microextrac-tion followed by gas chromatography-mass spectrom-etry[J].Journal of Chromatography A,2010,1217(29):4771-4778
• [18]Goksoyr A,Tollefsen K E,Grung M,et al.Balsa raft crossing the Pacific finds low contaminant levels[J].Environmental Science&Technology,2009,43(13):4783-4790
• [19]Zhang Z,Ren N,Li Y F,et al.Determination of benzotriazole and benzophenone UV filters in sedi-ment and sewage sludge[J].Environmental Science&Technology,2011,45(9):3909-3916
• [20]Nakata H,Murata S,Filatreau J.Occurrence and concentrations of benzotriazole UV stabilizers in ma-rine organisms and sediments from the Ariake Sea,Japan[J].Environmental Science&Technology,2009,43(18):6920-6926
• [21]Gago-Ferrero P,Diaz-Cruz M S,Barcelo D.Fast pressurized liquid extraction with in-cell purification and analysis by liquid chromatography tandem mass spectrometry for the determination of UV filters and their degradation products in sediments[J].Analyti-cal and Bioanalytical Chemistry,2011,400(7):2195-2204
• [22]Kameda Y,Tamada M,Kanai Y,et al.Occurrence of organic UV filters in surface waters,sediments,and core sediments in Tokyo Bay,-organic UV filters are new POPs?[J].Organohalogen Compounds,2007,69(4):263-266
• [23]Sanchez-Brunete C,Miguel E,Albero B,et al.Anal-ysis of salicylate and benzophenone-type UV filters in soils and sediments by simultaneous extraction clean-up and gas chromatography-mass spectrometry[J].Journal of Chromatography A,2011,1218(28):4291-4298
• [24]Buser H R,Balmer M E,Schmid P,et al.Occur-rence of UV filters4-methylbenzylidene camphor and octocrylene in fish from various Swiss rivers with in-puts from wastewater treatment plants[J].Environ-mental Science&Technology,2006,40(5):1427-1431
• [25]Bachelot M,Li Z,Munaron D,et al.Organic UV filter concentrations in marine mussels from French coastal regions[J].Science of the Total Environ-ment,2012,420(6):273-279
• [26]Diaz-Cruz M S,Gago-Ferrero P,Llorca M,et al.A-nalysis of UV filters in tap water and other clean wa-ters in Spain[J].Analytical and Bioanalytical Chem-istry,2012,402(7):2325-2333
• [27]Negreira N,Rodriguez I,Rubi E,et al.Determina-tion of selected UV filters in indoor dust by matrix solid-phase dispersion and gas chromatography-tan-dem mass spectrometry[J].Journal of Chromatogra-phy A,2009,1216(31):5895-5902
• [28]Calafat A M,Wong L Y,Ye X Y,et al.Concentra-tions of the sunscreen agent benzophenone-3in resi dents of the United States:National Health and Nu trition Examination Survey2003-2004[J].Environ mental Health Perspectives,2008,116(7):893-897
• [29]Schlumpf M,Kypke K,Wittassek M,et al.Expo sure patterns of UV filters,fragrances,parabens phthalates,organochlor pesticides,PBDEs,and PCBs in human milk correlation of UV filters with use of cosmetics[J].Chemosphere,2010,81(10)1171-1183
• [30]Krause M,Klit A,Blomberg Jensen M,et al.Sun screens:Are they beneficial for health?An overview of endocrine disrupting properties of UV-filters[J]International Journal of Andrology,2012,35(3)424-436
• [31]李立平,魏东斌,李敏,等.有机紫外防晒剂内分泌干扰效应研究进展[J].环境化学,2012,31(2)150-156Li L P,Wei D B,Li M,et al.Review on endocrine disrupting effects of organic UV filters[J].Environ mental Chemistry,2012,31(2):150-156(in Chi nese)
• [32]Kunz P Y,Galicia H F,Fent K.Comparison of in vitro and in vivo estrogenic activity of UV filters in fish[J].Toxicological Sciences,2006,90(2):349-361
• [33]Zucchi S,Oggier D M,Fent K.Global gene expres sion profile induced by the UV-filter2-ethyl-hexyl-4trimethoxycinnamate(EHMC)in zebrafish(Danio rerio)[J].Environmental Pollution,2011,159(10):3086-3096
• [34]Zucchi S,Bluthgen N,Ieronimo A,et al.The UV absorber benzophenone-4alters transcripts of genes involved in hormonal pathways in zebrafish(Danio rerio)eleuthero-embryos and adult males[J].Toxi cology and Applied Pharmacology,2011,250(2)137-146
• [35]Christen V,Zucchi S,Fent K.Effects of the UV-fil ter2-ethyl-hexyl-4-trimethoxycinnamate(EHMC)on expression of genes involved in hormonal pathways in fathead minnows(Pimephales promelas)and link to vitellogenin induction and histology[J].Aquatic Toxicology,2011,102(3-4):167-176
• [36]Kunz P Y,Gries T,Fent K.The ultraviolet filter3benzylidene camphor adversely affects reproduction in fathead minnow(Pimephales promelas)[J].Toxi cological Sciences,2006,93(2):311-321
• [37]Weisbrod C J,Kunz P Y,Zenker A K,et al.Effectsof the UV filter benzophenone-2on reproduction in fish[J].Toxicology and Applied Pharmacology,2007,225(3):255-266
• [38]Kunz P Y,Galicia H F,Fent K.Assessment of hor-monal activity of UV filters in tadpoles of frog Xeno-pus laevis at environmental concentrations[J].Ma-rine Environmental Research,2004,58(2-5):431-435
• [39]Petersen K,Tollefsen K E.Assessing combined tox-icity of estrogen receptor agonists in a primary cul-ture of rainbow trout(Oncorhynchus mykiss)hepato-cytes[J].Aquatic Toxicology,2011,101(1):186-195
• [40]Kunz P Y,Fent K.Estrogenic activity of ternary UV filter mixtures in fish(Pimephales promelas):An a-nalysis with nonlinear isobolograms[J].Toxicology and Applied Pharmacology,2009,234(1):77-88
• [41]Schmitt C,Oetken M,Dittberner O,et al.Endo-crine modulation and toxic effects of two commonly used UV screens on the aquatic invertebrates Pota-mopyrgus antipodarum and Lumbriculus variegatus[J].Environmental Pollution,2008,152(2):322-329
• [42]Kaiser D,Sieratowicz A,Zielke H,et al.Ecotoxico-logical effect characterisation of widely used organic UV filters[J].Environmental Pollution,2012,163(4):84-90
• [43]Fent K,Kunz P Y,Zenker A,et al.A tentative en-vironmental risk assessment of the UV-filters3-(4-methylbenzylidene-camphor),2-ethyl-hexyl-4-trime-thoxycinnamate,benzophenone-3,benzophenone-4and3-benzylidene camphor[J].Marine Environmen-tal Research,2010,69(s):S4-S6
• [44]Sieratowicz A,Kaiser D,Behr M,et al.Acute and chronic toxicity of four frequently used UV filter substances for Desmodesmus subspicatus and Daph-nia magna[J].Journal of Environmental Science and Health Part A,2011,46(12):1311-1319
• [45]Kusk K O,Avdolli M,Wollenberger L.Effect of2,4-dihydroxybenzophenone(BP1)on early life-stage development of the marine copepod Acartia tonsa at different temperatures and salinities[J].Environ-mental Toxicology and Chemistry,2011,30(4):959-966
• [46]Danovaro R,Bongiorni L,Corinaldesi C,et al.Sun-screens cause coral bleaching by promoting viral in-fections[J].Environmental Health Perspectives,2008,116(4):441-447