环境内分泌干扰物低剂量-效应研究进展Research Progress in the Low-Dose Effects of Environmental Endocrine Disrupting Chemicals
卫立;张洪昌;张爱茜;尹大强;
摘要(Abstract):
环境内分泌干扰物(EDCs)的低剂量-效应已成为生态毒理学界的研究热点.环境内分泌干扰物在接近或低于无可见不良效应浓度水平(NOAEL)时仍可诱发生物效应并存在非单调剂量-效应关系,这对现行的动物繁殖和发育毒理学检测规程以及环境内分泌干扰物风险评价的理论和方法提出了挑战.此外,由于环境中内分泌干扰物呈低剂量长期暴露的特征,研究低剂量-效应对正确进行生态风险评价具有重大的科学意义.在总结国内外相关研究的基础上,对当前环境内分泌干扰物低剂量-效应的研究进展进行了综述.
关键词(KeyWords): 环境内分泌干扰物;低剂量-效应;剂量-效应关系;风险评价
基金项目(Foundation): 国家自然科学基金项目(No.20377022)
作者(Author): 卫立;张洪昌;张爱茜;尹大强;
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DOI:
参考文献(References):
- Ashby J,Odum J.2004.Gene expression changes in theimmature rat uterus:Effects of uterotrophic and sub-uterotrophicdoses of bisphenol A[J].Toxicol Sci,82:458-467
- Ashby J,Tinwell H,Haseman J.1999.Lack of effects for lowdose levels of bisphenol A(BPA)and diethylstilbestrol(DES)onthe prostate gland of CF1mice exposed in utero[J].RegulToxicol Pharmacol,30:156-166
- Cagen S Z,Waechter J M,Dimond S S,Breslin W J,Butala JH,Jekat F W.1999.Normal reproductive organ development inCF-1mice following prenatal exposure to bisphenol A[J].ToxicolSci,50:36-44
- Chahoud I,Grote K,Chris E,Talsness C.2005.Meeting report:Low dose workshop commentary.International workshop on effectsof low doses of endocrine active compounds,Berlin,Germany,November20-22,2005[J].Environmental Research,98:400-401
- Chitra K C,Latchoumycandane C,Mathur P P.2003.Inductionof oxidative stress by bisphenol A in the epididymal sperm ofrats[J].Toxicology,185:119-127
- Gupta C.2000.Reproductive malformation of the male offspringfollowing maternal exposure to estrogenic chemicals[J].Proc SocExp Biol Med,224:61-68
- Hayes,T B,Collins A,Lee M,Mendoza M,Noriega N,StuartA A,Vonk A.2002.Hermaphroditic,demasculinized frogs afterexposure to the herbicide,atrazine,at low ecologically relevantdoses[J].Proceedings of the National Academy of Sciences(US),99:5476-5480
- Honma S,Suzuki A,Buchanan D L,Katsu Y,Watanabe H,Iguchi T.2002.Low dose effect of in utero exposure tobisphenol A and diethylstilbestrol on female mouse reproduction[J].Reprod Toxicol,16:117-122
- Hunt P A,Koehler K E,Susiarjo M,Hodges C A,Hagan A,Voigt R C.2003.Bisphenol A causes meiotic aneuploidy in thefemale mouse[J].Current Biol,13:546-553
- IRIS.1988.Bisphenol A(CASRN80-05-7)[OL].Washington,DC:U.S.Environmental Protection Agency.2006-2-17.http://www.epa.gov/iris/subst/0356.htm
- Kaiser J.2003.Hormesis:Sipping from a poisoned chalice[J].Science,302:376-379
- Melnick R,Lucier G,Wolfe M,Hall R,Stancel G,Prins G,Gallo M,Reuhl K,Ho S M,Brown T,Moore J,Leakey J,Haseman J,Kohn M.2002.Summary of the national toxicologyprogram’s report of the endocrine disruptors low-dose peer review[J].Environ Health Perspect,110:427-431
- Milloy S.2005.California’s bogus baby bottle scare[OL].2006-7-16.http://www.junkscience.com
- Nagel S C,Saal F S,Thayer K A,Dhar M G,Boechler M,Welshons W V.1997.Relative binding affinity-serum modifiedaccess(RBA-SMA)assay predicts the relative in vivo bioactivityof the xenoestrogens bisphenol A and octylphenol[J].EnvironHealth Perspect,105:70-76
- Nikaido Y,Yoshizawa K,Danbara N,Tsujita-Kyutoku M,YuriT,Uehara N.2004.Effects of maternal xenoestrogen exposure ondevelopment of the reproductive tract and mammary gland infemale CD-1mouse offspring[J].Reprod Toxicol,18:803-811
- Payne J,Scholze M,Kortenkamp A.2001.Mixtures of fourorganochlorines enhance human breast cancer cell proliferation[J].Environ Health Perspect,109:391-397
- Saal F S,Hughes C.2005.An extensive new literature concerninglow-dose effects of bisphenol A shows the need for a new riskassessment[J].Environ Health Perspect,113:926-933
- Saal F S,Timms B G,Montano M M,Palanza P,Thayer K A,Nagel S C,Dhar M D,Ganjam V K,Parmigiani S,Welshons WV.1997.Prostate enlargement in mice due to fetal exposure tolow doses of estradiol or diethylstilbestrol and opposite effects athigh doses[J].Proc Natl Acad Sci USA,94:2056-2061
- Sakaue M,Ohsako S,Ishimura R,Kurosawa S,Kurohmaru M,Hayashi Y.2001.Bisphenol A affects spermatogenesis in theadult rat even at low doses[J].J Occup Health,43:185-190
- Sugiura-Ogasawara M,Ozaki Y,Sonta S,Makino T,Suzumori K.2005.Exposure to bisphenol A is associated with recurrentmiscarriage[J].Hum Reprod,20:2325-2329
- Takeuchi T,Tsutsumi O,Ikezuki Y,Takai Y,Taketani Y.2004.Positive relationship between androgen and the endocrine disruptor,bisphenol A,in normal women and women with ovarian dysfunction[J].Endocr J,51(2):165-169
- Wei L,Wang B,Liu S S,Yin D Q.2006.On single andcombined estrogenic effects of bisphenol A an17β-estradiol atlow-dose using MCF-7cell proliferation[J].Acta Scientiae Circumstantiae,26(6):968-972(in Chinese)
- Welshons W V,Thayer K A,Judy B M,Taylor J A,Curran EM,Saal F S.2003.Large effects from small exposures.I.Mechanismsfor endocrine-disrupting chemicals with estrogenic activity[J].Environ Health Perspect,111:994-1006
- 卫立,王斌,刘树深,尹大强.2006.低剂量双酚A与17β雌二醇对MCF-7增殖作用的剂量-效应关系及其联合作用探索[J].环境科学学报,26(6):968-972