卢晓霞;Lawrence Lessner;David O.Carpenter;

• 1:北京大学城市与环境学院地表过程分析与模拟教育部重点实验室
• 2:纽约州立大学奥尔巴尼分校健康与环境研究所

摘要(Abstract)：

持久性有机污染物(persistent organic polutants,简称POPs)大多具有毒性,有的甚至致癌,但目前对POPs引起的健康风险仍知之甚少。本研究的假设是在含POPs场地邮政区居住妇女的乳腺癌风险增大。从纽约州计划与研究合作系统(SPARCS)等数据库中收集乳腺癌患者的信息及居住地危险废弃物暴露、经济收入和城市化等数据。以邮政区编码表征居住地,采用负二项回归方法,对纽约州30岁以上妇女乳腺癌医院出院率进行了模型分析,参数包括种族、年龄、污染暴露、经济收入和城市化率。结果显示,不同参数之间(如暴露与种族、暴露与收入、暴露与城市化)存在交互作用。对部分子群而言,与居住在不含危险废弃物场地邮政区的妇女相比,居住在含POPs场地邮政区的妇女乳腺癌出院率显著升高(率比(rate ratio,RR)1.10~1.34,P<0.05)。这种关系在非裔妇女中强于白种妇女、在城市化高的地区强于农村地区。调整了混杂因素后,某些妇女人群乳腺癌出院率升高与在含POPs场地邮政区居住有显著的关系。

关键词(KeyWords)： 持久性有机污染物;乳腺癌;医院出院率;妇女;居住

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(41471391,41071311,40871214);; 教育部新世纪优秀人才支持计划项目(NCET-10-0200)

作者(Author): 卢晓霞;Lawrence Lessner;David O.Carpenter;

Email:

DOI:

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