斑马鱼及其胚胎在毒理学中的实验研究与应用进展Experimental Research and Application of Zebrafish and Embryos in Toxicology
王佳佳;徐超;屠云杰;傅正伟;刘维屏;
摘要(Abstract):
作为一种模式生物,斑马鱼具有很多其他模式生物所不具备的优点,已被广泛应用于生物学各领域,具有十分广阔的发展前景.论文首先介绍了斑马鱼的基因组学,包括正向遗传学、反向遗传学以及斑马鱼在药物研发和人类疾病研究中的应用;其次就斑马鱼在发育生物学中的应用进行了概述;最后,介绍了斑马鱼在毒理学各方面(急性毒性、内分泌干扰、发育毒性、神经毒性、血管研究和癌症研究)的应用进展.
关键词(KeyWords): 基因组学;细胞;毒理学;转基因;突变
基金项目(Foundation): 教育部长江学者与创新团队发展计划项目(No.IRT0653);; 国家自然科学基金项目(No.20577045)
作者(Author): 王佳佳;徐超;屠云杰;傅正伟;刘维屏;
Email:
DOI:
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