范功端;陈薇;郑小梅;彭慧萍;

• 1:福州大学土木工程学院
• 2:福州大学新能源材料研究所

摘要(Abstract)：

纳米材料因其独特的性质被广泛应用于生物医疗、光学工程、催化等领域。随着纳米材料的生产量逐年增大,越来越多的纳米粒子被释放到水生生态环境中,其生态毒性效应影响也备受人们的关注。本文根据纳米材料的分类总结了不同种类纳米材料对水生生态系统的初级生产者藻类的毒性效应,归纳了纳米材料影响藻类毒性大小的主要因素,如纳米材料的物理化学性质、水体性质和藻种等,并探讨了纳米材料对藻类的致毒机理,如金属离子溶出、氧化损伤和遮光效应等,最后总结展望了纳米毒理学研究的发展方向,以期为纳米材料对藻类的毒性研究提供一定的理论依据。

关键词(KeyWords)： 纳米材料;藻;细胞毒性效应;致毒机理

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(51778146,51308123);; 中国博士后科学基金项目(2014M561856)

作者(Author): 范功端;陈薇;郑小梅;彭慧萍;

Email:

参考文献(References)：

• [1]Lin D,Xing B.Phytotoxicity of nanoparticles:Inhibition of seed germination and root growth[J].Environmental Pollution,2007,150(2):243-250
• [2]Nagarajan R.Nanoparticles:Building Blocks for Nanotechnology[M].Kluwer Academic/Plenum Publishers,2008:2-14
• [3]Rocha T L,Gomes T,Sousa V S,et al.Ecotoxicological impact of engineered nanomaterials in bivalve molluscs:An overview[J].Marine Environmental Research,2015,111:74-88
• [4]Biswas P,Wu C Y.Nanoparticles and the environment[J].Journal of the Air and Waste Management Association,2005,55(6):708-746
• [5]Nowack B,Bucheli T D.Occurrence,behavior and effects of nanoparticles in the environment[J].Environmental Pollution,2007,150(1):5-22
• [6]FarréM,Gajda-Schrantz K,Kantiani L,et al.Ecotoxicity and analysis of nanomaterials in the aquatic environment[J].Analytical and Bioanalytical Chemistry,2009,393(1):81-95
• [7]Service R F.Nanotechnology grows up[J].Science,2004,332(6034):1140-1143
• [8]Service R F.Nanomaterials show signs of toxicity[J].Science,2003,300(5617):243
• [9]章军,杨军,朱心强.纳米材料的环境和生态毒理学研究进展[J].生态毒理学报,2006,1(4):350-356Zhang J,Yang J,Zhu X Q.The advancement of environmental and ecotoxicological research of nanomaterials[J].Asian Journal of Ecotoxicology,2006,1(4):350-356(in Chinese)
• [10]Wang Z,Li N,Zhao J,et al.Cu O nanoparticle interaction with human epithelial cells:Cellular uptake,location,export,and genotoxicity[J].Chemical Research in Toxicology,2012,25(7):1512-1521
• [11]Nel A,Xia T,Madler L,et al.Toxic potential of materials at the nanolevel[J].Science,2006,311(5761):622-627
• [12]Lam C W,James J T,Mccluskey R,et al.A review of carbon nanotube toxicity and assessment of potential occupational and environmental health risks[J].Critical Reviews in Toxicology,2006,36(3):189-217
• [13]Monterio-Riviere N A,Nemanich R J,Inman A O,et al.Multi-walled carbon nanotube interactions with human epidermal keratinocytes[J].Toxicology Letters,2005,155(3):377-384
• [14]Ji J,Long Z,Lin D.Toxicity of oxide nanoparticles to the green algae Chlorella sp.[J].Chemical Engineering Journal,2011,170(s2-3):525-530
• [15]DědkováK,Bure2 Z,Palarˇcík J,et al.Acute aquatic toxicity of gold nanoparticles to freshwater green algae[R].Bron:[s.n.],2014
• [16]Hazani A A,Ibrahim M M,Shehata A I,et al.Ecotoxicity of Ag-nanoparticles on two microalgae,Chlorella vulgaris and Dunaliella tertiolecta[J].Archives of Biological Sciences,2013,65(4):1447-1457
• [17]Wang Z,Li J,Zhao J,et al.Toxicity and internalization of Cu O nanoparticles to prokaryotic alga Microcystis aeruginosa as affected by dissolved organic matter[J].Environmental Science and Technology,2011,45(14):6032-6040
• [18]Nogueira P F M,Nakabayashi D,Zucolotto V.The effects of graphene oxide on green algae Raphidocelis subcapitata[J].Aquatic Toxicology,2015,166:29-35
• [19]Wei L,Thakkar M,Chen Y,et al.Cytotoxicity effects of water dispersible oxidized multiwalled carbon nanotubes on marine alga,Dunaliella tertiolecta[J].Aquatic Toxicology,2010,100(2):194-201
• [20]Dash A,Singh A P,Chaudhary B R,et al.Effect of silver nanoparticles on growth of eukaryotic green algae[J].Nano-Micro Letters,2012,4(3):158-165
• [21]Chae Y,An Y J.Toxicity and transfer of polyvinylpyrrolidone-coated silver nanowires in an aquatic food chain consisting of algae,water fleas,and zebrafish[J].Aquatic Toxicology,2016,173:94
• [22]Ivask A,Kurvet I,Kasemets K,et al.Size-dependent toxicity of silver nanoparticles to bacteria,yeast,algae,crustaceans and mammalian cells in vitro[J].Plo S One,2014,9(7):e102108
• [23]Pillai S,Behra R,Nestler H,et al.Linking toxicity and adaptive responses across the transcriptome,proteome,and phenotype of Chlamydomonas reinhardtii exposed to silver[J].Proceedings of the National Academy of Sciences of the United States of America,2014,111(9):3490-3495
• [24]Oukarroum A,Bras S,Perreault F,et al.Inhibitory effects of silver nanoparticles in two green algae,Chlorella vulgaris and Dunaliella tertiolecta[J].Ecotoxicology and Environmental Safety,2012,78(2):80-85
• [25]Burchardt A D,Carvalho R N,Valente A,et al.Effects of silver nanoparticles in diatom Thalassiosira pseudonana and cyanobacterium Synechococcus sp.[J].Environmental Science and Technology,2012,46(20):11336-11344
• [26]Tuominen M,Schultz E,SillanpaaM.Toxicity and stability of silver nanoparticles to the green alga Pseudokirchneriella subcapitata in boreal freshwater samples and growth media[J].Nanomaterials and the Environment,2013,1:48-57
• [27]Iswarya V,Manivannan J,De A,et al.Surface capping and size-dependent toxicity of gold nanoparticles on different trophic levels[J].Environmental Science and Pollution Research,2015,1:1-15
• [28]Bozich J,Lohse S,Torelli M,et al.Surface chemistry,charge and ligand type impact the toxicity of gold nanoparticles to Daphnia magna[J].Environment Science Nano,2014,1(3):260-270
• [29]傅凤,刘振乾,陈传红.纳米铜粉对浮游植物生长的影响[J].生态科学,2007,26(2):126-130Fu F,Liu Z Q,Chen C H.Pilot study about effects of copper nanoparticle on phytoplankton growth[J].Ecologic Science,2007,26(2):126-130(in Chinese)
• [30]李芳芳,潘容,张偲,等.纳米铜粉对中肋骨条藻的毒性效应[J].中国环境科学,2015,35(9):2874-2880Li F F,Pan R,Zhang C,et al.Inhibition effects of copper nanoparticles on the growth of Skeletonema costatum[J].China Environmental Science,2015,35(9):2874-2880(in Chinese)
• [31]Aruoja V,Dubourguier H C,Kasemets K,et al.Toxicity of nanoparticles of Cu O,Zn O and Ti O2to microalgae Pseudokirchneriella subcapitata[J].Science of the Total Environment,2009,407(4):1461-1468
• [32]Franklin N M,Rogers N J,Apte S C,et al.Comparative toxicity of nanoparticulate Zn O,bulk Zn O,and Zn Cl2to a freshwater microalga(Pseudokirchneriella subcapitata):The importance of particle solubility[J].Environmental Science and Technology,2007,41(24):8484-8490
• [33]刘建新,杜青平,陈展明,等.纳米氧化锌对羊角月牙藻毒性效应及其在藻细胞内外的分布[J].生态毒理学报,2016,11(5):103-110Liu J X,Du Q P,Chen Z M,et al.Toxicities of Zn O nanoparticles on Selenastrum capricornutum and its distributions in intra-and extra-cells[J].Asian Journal of Ecotoxicology,2016,11(5):103-110(in Chinese)
• [34]Hall S,Bradley T,Moore J T,et al.Acute and chronic toxicity of nano-scale Ti O2particles to freshwater fish,cladocerans,and green algae,and effects of organic and inorganic substrate on Ti O2toxicity[J].Nanotoxicology,2009,3(2):91-97
• [35]Hoecke K V,Quik J T K,Mankiewiczboczek J,et al.Fate and effects of Ce O2nanoparticles in aquatic ecotoxicity tests[J].Environmental Science and Technology,2009,43(12):4537-4546
• [36]Pakrashi S,Dalai S,Prathna T C,et al.Cytotoxicity ofaluminium oxide nanoparticles towards fresh water algal isolate at low exposure concentrations[J].Aquatic Toxicology,2013,132-133(10):34-45
• [37]Roy R,Parashar A,Bhuvaneshwari M,et al.Differential effects of P25 Ti O2nanoparticles on freshwater green microalgae:Chlorella and Scenedesmus species[J].Aquatic Toxicology,2016,176:161-171
• [38]邓祥元,胡小丽,成婕,等.纳米二氧化铈对蛋白核小球藻的生物学效应研究[J].生态毒理学报,2016,11(5):111-116Deng X Y,Hu X L,Cheng J,et al.Effects of nanoparticle Ce O2on the physiology of Chlorella pyrenoidosa[J].Asian Journal of Ecotoxicology,2016,11(5):111-116(in Chinese)
• [39]Kwok K W,Leung K M,Flahaut E,et al.Chronic toxicity of double-walled carbon nanotubes to three marine organisms:Influence of different dispersion methods[J].Nanomedicine,2010,5(6):951-961
• [40]Blaise C,GagnéF,Férard J F,et al.Ecotoxicity of selected nano-materials to aquatic organisms[J].Environmental Toxicology,2008,23(5):591-598
• [41]杨晓静,陈灏,闫海,等.纳米二氧化钛和单壁碳纳米管对普通小球藻生长的抑制效应[J].生态毒理学报,2010,5(1):38-43Yang X J,Chen H,Yan H,et al.Effects of nano-Ti O2and single-walled carbon nanotubes on the growth of Chlorella vulgaris[J].Asian Journal of Ecotoxicology,2010,5(1):38-43(in Chinese)
• [42]Wahid M H,Eroglu E,Chen X,et al.Entrapment ofChlorella vulgaris cells within graphene oxide layers[J].RSC Advances,2013,3(22):8180-8183
• [43]Nogueira P F,Nakabayashi D,Zucolotto V.The effects of graphene oxide on green algae Raphidocelis subcapitata[J].Aquatic Toxicology(Amsterdam,Netherlands),2015,166(8):29
• [44]Jian Z,Cao X,Wang Z,et al.Mechanistic understanding toward the toxicity of graphene-family materials to freshwater algae[J].Water Research,2016,111:18-27
• [45]Hana H,Kubatova K,Zemanova Z,et al.Evaluation of effects of C60fullerene and its derivatives on selected microorganisms[J].材料科学与工程:中英文B版,2013,13(7):409-417
• [46]钟秋.纳米二氧化铈和硫化镉量子点对水生生物的毒性研究[D].武汉:华中师范大学,2013:22-23Zhong Q.The toxicity of nano cerium dioxicide and cadmium sulfide quantum dots to tow aquatic organisms[D].Wuhan:Central China Normal University,2013:22-23(in Chinese)
• [47]Rodea-Palomares I,Boltes K,Fernandez-Pinas F,et al.Physicochemical characterization and ecotoxicological assessment of Ce O2nanoparticles using two aquatic microorganisms[J].Toxicological Sciences,2011,199(1):135-145
• [48]Tedescoa S,Doyle H,Blasco J,et al.Oxidative stress and toxicity of gold nanoparticles in Mytilus edulis[J].Aquatic Toxicology,2010,100:178-186
• [49]白伟,张程程,姜文君,等.纳米材料的环境行为及其毒理学研究进展[J].生态毒理学报,2009,4(2):174-182Bai W,Zhang C C,Jiang W J,et al.Progress in studies on environmental behaviors and toxicological effects of nanomaterials[J].Asian Journal of Ecotoxicology,2009,4(2):174-182(in Chinese)
• [50]Tedesco S,Doyle H,Blasco J,et al.Exposure of the blue mussel,Mytilus edulis,to gold nanoparticles and the pro-oxidant menadione[J].Comparative Biochemistry and Physiology Part C Toxicology and Pharmacology,2010,151(2):167-174
• [51]Hund-Rinke K,Simon M.Ecotoxic effect of photocatalytic active nanoparticles(Ti O2)on algae and Daphnids[J].Environmental Science and Pollution Research,2006,13(4):225-232
• [52]Matzke M,Jurkschat K,Backhaus T.Toxicity of differently sized and coated silver nanoparticles to the bacterium Pseudomonas putida:Risks for the aquatic environment?[J].Ecotoxicology,2014,23:818-829
• [53]Coleman J G,Kennedy A J,Bednar A J,et al.Comparing the effects of nanosilver size and coating variations on bioavailability,internalization,and elimination,using Lumbriculus variegatus[J].Environmental Toxicology and Chemistry,2013,32(9):2069-2077
• [54]张宁.人工纳米材料对藻类的生物效应研究[D].天津:天津理工大学,2011:16-19Zhang N.Biological effects of artificial nanomaterials on alga[D].Tianjin:Tianjin University of Technology,2011:16-19(in Chinese)
• [55]牟凤伟.不同类型的碳纳米管对斜生栅藻的毒性效应研究[D].长沙:中南林业科技大学,2013:43-44Mou F W.The toxicity effects of different types of CNTs on Scenedesmus obliquus[D].Changsha:Central South University of Forestry and Technology,2013:43-44(in Chinese)
• [56]Manier N,Bado-Nilles A,Delalain P,et al.Ecotoxicity of non-aged and aged Ce O2nanomaterials towards freshwater microalgae[J].Environmental Pollution,2013,180(3):63-70
• [57]汪静,刘娅琛,曲冰,等.金属纳米颗粒对蛋白核小球藻生长活性的影响[J].大连海洋大学学报,2011,26(5):386-390Wang J,Liu Y C,Qu B,et al.The effect of the metal nanoparticles(Fe/Ni)on growth in alga Chlorella pyrenoidosa[J].Journal of Dalian Ocean University,2011,26(5):386-390(in Chinese)
• [58]Xie B,Xu Z,Guo W,et al.Impact of natural organic matter on the physicochemical properties of aqueous C60nanoparticles[J].Environmental Science and Technology,2008,42(8):2853-2859
• [59]Lamelas C,Slaveykova V I.Comparison of Cd(II),Cu(II),and Pb(II)biouptake by green algae in the presence of humic acid[J].Environmental Science and Technology,2007,41(11):4172-4178
• [60]Sun P,Shijirbaatar A,Jing F,et al.Distinguishable transport behavior of zinc oxide nanoparticles in silica sand and soil columns[J].Science of the Total Environment,2015,505:189-198
• [61]雷静静,冯佳,谢树莲.纳米氧化镍对3种绿藻的毒性效应[J].中国环境科学,2013,33(10):1842-1849Lei J J,Feng J,Xie S L.Toxic effects of n Ni O on three species of green algae[J].China Environmental Science,2013,33(10):1842-1849(in Chinese)
• [62]胡冰,王华,张冬冬,等.纳米Ti O2和Cu(Ⅱ)、Zn(Ⅱ)对小球藻和新月菱形藻的毒性研究[J].大连海洋大学学报,2015(5):489-493Hu B,Wang H,Zhang D D,et al.Toxicity of Ti O2nanoparticles,Cu(Ⅱ)and Zn(Ⅱ)to Chlorella sp.and Nitzschia closterium[J].Journal of Dalian Ocean University,2015(5):489-493(in Chinese)
• [63]Klaine S J,Alvarez P J J,Batley G E,et al.Nanomaterials in the environment:Behavior,fate,bioavailbility and effects[J].Environmental Toxicology and Chemistry,2008,27(9):1825-1851
• [64]Vogelsberger W,Schmidt J,Roelofs F.Dissolution kinetics of oxidic nanoparticles:The observation of an unusual behaviour[J].Colloids and Surfaces A Physicochemical and Engineering Aspects,2008,324(1-3):51-57
• [65]Miao A J,Schwehr K A,Xu C,et al.The algal toxicity of silver engineered nanoparticles and detoxification by exopolymeric substances[J].Environmental Pollution,2009,157(11):3034-3041
• [66]Saison C,Perreault F,Daigle J C,et al.Effect of coreshell copper oxide nanoparticles on cell culture morphology and photosynthesis(photosystem II energy distribution)in the green alga,Chlamydomonas reinhardtii[J].Aquatic Toxicology,2010,96(2):109-114
• [67]Navarro E,Piccapietra F,Wagner B,et al.Toxicity of silver nanoparticles to Chlamydomonas reinhardtii[J].Environmental Science and Technology,2008,42(23):8959-8964
• [68]王震宇,赵建,李娜,等.人工纳米颗粒对水生生物的毒性效应及其机制研究进展[J].环境科学,2010,31(6):1409-1418Wang Z Y,Zhao J,Li N,et al.Review of ecotoxicity and mechanism of engineered nanoparticles to aquatic organisms[J].Environmental Science,2010,31(6):1049-1418(in Chinese)
• [69]Xia T,Kovochich M,Liong M,et al.Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways[J].ACS Nano,2008,2(1):85-96
• [70]马菲菲,孙雪梅,韩倩,等.不同粒径Ti O2颗粒对海洋微藻的毒性效应[J].海洋学报,2015,37(10):100-105Ma F F,Sun X M,Han Q,et al.Toxic effects of Ti O2particles with different size on the marine microalga[J].Haiyang Xuebao,2015,37(10):100-105(in Chinese)
• [71]Wang J,Zhang X,Chen Y,et al.Toxicity assessment of manufactured nanomaterials using the unicellular green alga Chlamydomonas reinhardtii[J].Chemosphere,2008,73(7):1121-1128
• [72]Fabienne S,Bucheli T D,Lukhele L P,et al.Are carbon nanotube effects on green algae caused by shading and agglomeration?[J].Environmental Science and Technology,2011,45(14):6136-6144
• [73]Lin S,Bhattacharya P,Rajapakse N C,et al.Effects of quantum dots adsorption on algal photosynthesis[J].Journal of Physical Chemistry C,2009,113(25):10962-10966