陈玫宏;徐怀洲;宋宁慧;张芹;张圣虎;李江;

• 1:生态环境部南京环境科学研究所
• 2:贵州大学资源与环境工程学院

摘要(Abstract)：

羟基化多溴联苯醚(OH-PBDEs)是一类具有内分泌干扰效应的酚类化合物,以小鼠肝脏微粒体作为研究对象,考察了OH-PBDEs的体外代谢行为及对雌激素代谢的影响。研究结果发现,4种OH-PBDE均能够代谢,其代谢率大小为6-OH-BDE-99>6’-OH-BDE-99>6-OH-BDE-137>5’-OH-BDE-99,表明羟基官能团(-OH)与醚键及溴原子处于邻位时,表现出较高的代谢率; 4种OH-PBDE对3种天然雌激素包括雌酮(E1)、17β-雌二醇(E2)、雌三醇(E3)的代谢表现出不同作用,整体来说,对E1和E2代谢随着OH-PBDE浓度的增加抑制作用逐渐增强,对E3代谢则表现出促进作用,但是对人工合成的雌激素17α-炔雌醇(EE2)无明显影响;对E2代谢产物2-羟基雌二醇(2-OH-E2)的生成量定量表征表明,除6-OH-BDE-99促进了2-OH-E2的生成量,其余3种OH-PBDE随实验添加浓度的增加,抑制了2-OH-E2的生成量,这可能与酶介导的不同代谢机制有关。

关键词(KeyWords)： OH-PBDEs;肝脏微粒体;体外代谢;雌激素

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(No.21407055,51508120)

作者(Author): 陈玫宏;徐怀洲;宋宁慧;张芹;张圣虎;李江;

Email:

DOI:

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