苯和甲醛联合染毒对小鼠脾脏的损伤Spleen Tissue Damage in Mice from Combined Exposure of Benzene and Formaldehyde
问华肖;魏晨曦;陈绍恢;毛琳;杨旭;
摘要(Abstract)：
为了探讨苯和甲醛联合染毒对小鼠脾脏的损伤以及二者是否具有一定的协同作用,选择BALB/c雄性小鼠30只,随机分为5组,每组6只,设苯组、甲醛组、苯和甲醛联合染毒组及玉米油对照组和空白对照组,对小鼠进行气态甲醛吸入染毒或/和苯玉米油溶液灌胃染毒。染毒结束后对小鼠脾脏进行组织病理学观察,并且测定脾脏的脏器系数以及脾脏组织的活性氧(ROS)和丙二醛(MDA)的含量。结果显示,苯和甲醛联合染毒组小鼠脾脏组织中ROS的含量与空白对照组相比有极显著的上升趋势(P<0.01),脾脏的脏器系数以及脾脏组织中MDA的含量与空白对照组相比有显著性差异(P<0.05)。此外,在脾脏免疫组织形态变化以及脾脏组织中MDA含量这2个生理生化指标上,苯和甲醛联合染毒对小鼠脾脏的损伤具有一定的协同作用。
关键词(KeyWords)： 苯;甲醛;小鼠;脾脏
基金项目(Foundation): 国家自然科学基金重点项目(51136002)
作者(Author): 问华肖;魏晨曦;陈绍恢;毛琳;杨旭;
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DOI:
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