聂湘平;鹿金雁;李潇;杨宇峰;

• 1:暨南大学水生生物研究所
• 2:暨南大学水生生物研究所
• 3:暨南大学水生生物研究所
• 4:暨南大学水生生物研究所 广州510632

摘要(Abstract)：

以蛋白核小球藻(Chlorella pyrenoidosa)为实验材料,研究了喹诺酮类药物诺氟沙星(Norfloxacin,NFLX)对小球藻生长及抗氧化酶活性的影响.结果表明,NFLX对小球藻的96hEC50为30.78mg·L-1,属于低毒.NFLX暴露对小球藻谷胱甘肽硫转移酶(GST)和过氧化氢酶(CAT)具有显著影响,当NFLX浓度高于30mg·L-1时,小球藻GST活性受到显著诱导,并随NFLX浓度增加而显著升高,而小球藻CAT活性随NFLX暴露浓度的升高表现出先诱导后抑制现象.NFLX对谷胱甘肽(GSH)和7-乙氧基-异吩唑酮-脱乙基酶(EROD)的影响较弱.在低浓度NFLX暴露下,GST和CAT可作为NFLX暴露的生物标记物.

关键词(KeyWords)： 蛋白核小球藻;诺氟沙星;急性毒性;抗氧化酶活性

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(No.40471118);; 国家自然科学基金委与广东省联合基金项目(No.U0633006)

作者(Author): 聂湘平;鹿金雁;李潇;杨宇峰;

Email:

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