表观遗传学机制与空气污染的健康效应Epigenetic Mechanism and It's role in the Negative Health Effect of Air Pollution
吕占禄;王先良;钱岩;郭辰;梁豹;吴家兵;王菲菲;段小丽;张金良;
摘要(Abstract):
空气污染是一个全球性的问题,并且具有深远的环境影响。暴露于空气污染会对人体健康产生许多不同的影响,理解空气污染的健康效应又是一个复杂命题,既要考虑不同类型的污染物同时也要考虑相关疾病的复杂性。然而越来越多的研究表明,表观遗传学在空气污染相关疾病的发生、发展中发挥着重要的作用。空气污染物可引起DNA甲基化、组蛋白修饰和miRNA表达等表观遗传学改变,这种改变往往发生在疾病产生的早期,因此相关研究不仅可以了解疾病的发病机制,而且还为疾病早期诊断和预防筛选可能的标志物。本文综述了表观遗传学的几种修饰方式和空气污染物造成不良健康损伤机制的一些研究进展。
关键词(KeyWords): 多环芳烃;苯;颗粒物;烟草烟雾;空气污染;健康效应;表观遗传学
基金项目(Foundation): 国家自然科学基金(20907047);; 国家环保公益性行业科研专项(200909036,201309045);; 中国环境科学研究院中央级公益性科研院所基本科研业务专项基金(2008KYYW05)
作者(Author): 吕占禄;王先良;钱岩;郭辰;梁豹;吴家兵;王菲菲;段小丽;张金良;
Email:
DOI:
参考文献(References):
- [1]Larsson L,Castilho R M,Giannobile W V.Epigenetics and its role in periodontal diseases-a state-of-the-art review[J].Journal of Periodontology,2014,21(4):1-18
- [2]Wiwanitkit V.Physiological genomics analysis for mania:Supportive evidence for epigenetics concept[J].Indian Journal of Psychological Medicine,2014,36(4):366-367
- [3]Vandegehuchte M B,Janssen C R.Epigenetics and its implications for ecotoxicology[J].Ecotoxicology,2011,20(3):1-18
- [4]Lokody I.Epigenetics:Senescent cells:Poised for cancer[J].Nature Reviews Cancer,2014,14(1):11-11
- [5]Ji H,Khurana Hershey G K.Genetic and epigenetic influence on the response to environmental particulate matter[J].Journal of Allergy and Clinical Immunology,2012,129(1):33-41
- [6]Breton C V,Marutani A N.Air pollution and epigenetics:Recent findings[J].Current Environmental Health Reports,2014,4(8):1-11
- [7]Holloway J W,Savarimuthu Francis S,Fong K M,et al.Genomics and the respiratory effects of air pollution exposure[J].Respirology,2012,17(4):590-600
- [8]Carlsten C,Melen E.Air pollution,genetics,and allergy:An update[J].Current Opinion in Allergy and Clinical Immunology,2012,12(5):455-460
- [9]Bock C,Wutz A.DNA methylation:A matter of culture[J].Nature Structural and Molecular Biology,2013,20(3):249-251
- [10]Smith Z D,Meissner A.DNA methylation:Roles in mammalian development[J].Nature Reviews Genetics,2013,14(3):204-220
- [11]Satomi K M,Konako K K,Yusuke S D I,et al.DNA Methylation in Mouse Testes[M]//PIWI-Interacting RNAs.Springer,2014:97-109
- [12]Ziller M J,Gu H,Müller F,et al.Charting a dynamic DNA methylation landscape of the human genome[J].Nature,2013,500(7463):477-481
- [13]Mccarthy N.Epigenetics:Histone modification[J].Nature Reviews Cancer,2013,13(6):379-379
- [14]Zentner G E,Henikoff S.Regulation of nucleosome dynamics by histone modifications[J].Nature Structural and Molecular Biology,2013,20(3):259-266
- [15]Yang I V,Schwartz D A.Epigenetic mechanisms and the development of asthma[J].Journal of Allergy and Clinical Immunology,2012,130(6):1243-1255
- [16]Baer C,Claus R,Plass C.Genome-wide epigenetic regulation of miRNAs in cancer[J].Cancer Research,2013,73(2):473-477
- [17]Baccarelli A,Bollati V.Epigenetics and environmental chemicals[J].Current Opinion in Pediatrics,2009,21(2):243-251
- [18]Fernandez-Hernando C,Ramirez C M,Goedeke L,et al.MicroRNAs in metabolic disease[J].Arteriosclerosis Thrombosis and Vascular Biology,2013,33(2):178-185
- [19]Quiat D,Olson E N.MicroRNAs in cardiovascular disease:From pathogenesis to prevention and treatment[J].Journal of Clinical Investigation,2013,123(1):11-18.
- [20]谭聪,金永堂.常见空气污染的表观遗传效应研究进展[J].浙江大学学报:医学版,2011,40(4):451-460Tan C,Jin Y T.Current progress in research on epigenetic effects of air pollution[J].Jounal of Zhejiang University:Medical Sciences,2011,40(4):451-460(in Chinese)
- [21]Christensen B C,Marsit C J.Epigenomics in environmental health[J].Frontiers in Genetics,2011,2(84):1-10
- [22]De Prins S,Koppen G,Jacobs G,et al.Influence of ambient air pollution on global DNA methylation in healthy adults:A seasonal follow-up[J].Environment International,2013,59:418-424
- [23]Alexeeff S E,Litonjua A A,Wright R O,et al.Ozone exposure,antioxidant genes,and lung function in an elderly cohort:VA normative aging study[J].Occupational and Environmental Medicine,2008,65(11):736-742
- [24]Chahine T,Baccarelli A,Litonjua A,et al.Particulate air pollution,oxidative stress genes,and heart rate variability in an elderly cohort[J].Environmental Health Perspectives,2007,115(11):1617-1622
- [25]Tarantini L,Bonzini M,Apostoli P,et al.Effects of particulate matter on genomic DNA methylation content and i NOS promoter methylation[J].Environmental Health Perspectives,2009,117(2):217-222
- [26]Ehrlich M.DNA methylation in cancer:Too much,but also too little[J].Oncogene,2002,21(35):5400-5413
- [27]Castro R.5,10‐Methylenetetrahydrofolate reductase677C→T and 1298A→C mutations are genetic determinants of elevated homocysteine[J].Qjm,2003,96(4):297-303
- [28]Baccarelli A,Zanobetti A,Martinelli I,et al.Air pollution,smoking,and plasma homocysteine[J].Environmental Health Perspectives,2007,115(2):176-181
- [29]Castro R,Rivera I,Struys E A,et al.Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease[J].Clinical Chemistry,2003,49(8):1292-1296
- [30]Carmona J J,Sofer T,Hutchinson J,et al.Short-term airborne particulate matter exposure alters the epigenetic landscape of human genes associated with the mitogenactivated protein kinase network:A cross-sectional study[J].Journal of Environmental Health,2014,13(1):94-102
- [31]Soberanes S,Gonzalez A,Urich D,et al.Particulate matter air pollution induces hypermethylation of the p16promoter via a mitochondrial ROS-JNK-DNMT1 pathway[J].Scientific Reports,2012,2(3):275-283
- [32]Yauk C,Polyzos A,Rowan-Carroll A,et al.Germline mutations,DNA damage,and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location[J].Proceedings of the National Academy of Sciences,2008,105(2):605-610
- [33]Miousse I R,Chalbot M C,Aykin-Burns N,et al.Epigenetic alterations induced by ambient particulate matter in mouse macrophages[J].Environmental and Molecular Mutagenesis,2014,55(5):428-435
- [34]芦茜.细颗粒物对H9c2心肌细胞生长及β1受体基因甲基化并表达的影响[D].长沙:中南大学,2011Lu Q.Effect of fine particulate matter on cell vitality andβ1 adrenoceptor DNA methylation and expression in H9c2 myocardial cells[D].Changsha:Central South University,2011(in Chinese)
- [35]Pogribny I P,Beland F A.DNA hypomethylation in the origin and pathogenesis of human diseases[J].Cellular and Molecular Life Sciences,2009,66(14):2249-2261
- [36]Baccarelli A,Cassano P A,Litonjua A,et al.Cardiac autonomic dysfunction effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms[J].Circulation,2008,117(14):1802-1809
- [37]Bollati V,Schwartz J,Wright R,et al.Decline in genomic DNA methylation through aging in a cohort of elderly subjects[J].Mechanisms of Ageing and Development,2009,130(4):234-239
- [38]Liu J,Ballaney M,Al-Alem U,et al.Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and Ig E production in vivo[J].Toxicological Sciences,2008,102(1):76-81
- [39]Portha B,Fournier A,Ah Kioon M D,et al.Early environmental factors,alteration of epigenetic marks and metabolic disease susceptibility[J].Biochimie,2014,97:1-15
- [40]Jardim M J,Dailey L,Silbajoris R,et al.Distinct microRNA expression in human airway cells of asthmatic donors identifies a novel asthma-associated gene[J].American Journal of Respiratory Cell and Molecular Biology,2012,47(4):536-542
- [41]Ye Y,Wang K K,Gu J,et al.Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk[J].Cancer Prevention Research,2008,1(6):460-469
- [42]Verma M N,Agarwal S P,Verma M,et al.Chapter 4-Epigenetics and Animal Models:Applications in Cancer Control and Treatment,in Animal Biotechnology,A.S[M].San Diego:Academic Press,2014:57-72
- [43]Snyder R.Benzene and leukemia[J].CRC Critical Reviews in Toxicology,2002,32(3):155-210
- [44]Xing C,Wang Q F,Li B,et al.Methylation and expression analysis of tumor suppressor genes p15 and p16in benzene poisoning[J].Chemico-Biological Interactions,2010,184(1-2):306-309
- [45]Ji Z,Zhang L,Peng V,et al.A comparison of the cytogenetic alterations and global DNA hypomethylation induced by the benzene metabolite,hydroquinone,with those induced by melphalan and etoposide[J].Leukemia,2010,24(5):986-991
- [46]Salam M T.Asthma Epigenetics[M]//Heterogeneity in Asthma.Springer,2014:183-199
- [47]Hu J,Ma H,Zhang W,et al.Effects of benzene and its metabolites on global DNA methylation in human normal hepatic L02 cells[J].Environmental Toxicology,2014,29(1):108-116
- [48]Zhang L,Mchale C M,Rothman N,et al.Systems biology of human benzene exposure[J].Chemico-Biological Interactions,2010,184(1-2):86-93
- [49]Stein R A.Epigenetics and environmental exposures[J].Journal of Epidemiology and Community Health,2012,66(1):8-13
- [50]Huang H B,Chen G W,Wang C J,et al.Exposure to heavy metals and polycyclic aromatic hydrocarbons and DNA damage in Taiwanese traffic conductors[J].Cancer Cpidemiology,Diomarkers&Prevention,2013,22(1):102-108
- [51]Hew K M,Walker A I,Kohli A,et al.Childhood ex-posure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells[J].Clinical and Experimental Allergy,2014,22(11):85-91
- [52]Damiani L A,Yingling C M,Leng S,et al.Carcinogen-induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells[J].Cancer Research,2008,68(21):9005-9014
- [53]Pavanello S,Bollati V,Pesatori A C,et al.Global and gene‐specific promoter methylation changes are related to anti‐B[a]PDE‐DNA adduct levels and influence micronuclei levels in polycyclic aromatic hydrocarbon‐exposed individuals[J].International Journal of Cancer,2009,125(7):1692-1697
- [54]Al-Daghri N M,Alokail M S,Abd-Alrahman S H,et al.Polycyclic aromatic hydrocarbon exposure and pediatric asthma in children:A case-control study[J].Environmental Health:A Global Access Science Source,2013,13(2):1-12
- [55]Alegría-Torres J A,Barretta F,Batres-Esquivel L E,et al.Epigenetic markers of exposure to polycyclic aromatic hydrocarbons in Mexican brickmakers:A pilot study[J].Chemosphere,2013,91(4):475-480
- [56]Sadikovic B,Andrews J,Carter D,et al.Genome-wide H3K9 histone acetylation profiles are altered in benzopyrene-treated MCF7 breast cancer cells[J].Journal of Biological Chemistry,2008,283(7):4051-4060
- [57]Miller L L,Henderson J,Northstone K,et al.Do grandmaternal smoking patterns influence the etiology of childhood asthma?[J].Chest,2014,145(6):1213-1218
- [58]Murphy S K,Adigun A,Huang Z,et al.Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke[J].Gene,2012,494(1):36-43
- [59]Maccani M A,Avissar Whiting M,Banister C E,et al.Maternal cigarette smoking during pregnancy is associated with downregulation of miR-16,miR-21,and miR-146a in the placenta[J].Epigenetics,2010,5(7):583-589
- [60]陈秉衡,张蕴晖,阚海东.WHO最新大气质量基准—严峻的挑战[J].环境与健康,2007,24(4):187-188
- [61]吴丰昌,孟伟,等.中国环境基准体系中长期路线图[M].北京:科学出版社,2014