黄苑;苏晓鸥;王瑞国;张维;

• 1:中国农业科学院农业质量标准与检测技术研究所农业部农产品质量安全研究重点实验室

摘要(Abstract)：

多氯联苯作为一种环境内分泌干扰物,具有一定的雌激素干扰效应,导致动物雌激素水平紊乱或功能异常,从而影响生殖、发育或行为。羟基多氯联苯是多氯联苯最主要的活性代谢产物,已经在动物和人体组织中被检出。羟基多氯联苯的化学性质和分子空间构象使其雌激素干扰效应可能较母体化合物更强。因此,它们对人类和动物机体的潜在影响以及由此带来的新的毒理学问题成为内分泌干扰研究领域的热点之一,相关的毒性作用机制需要进一步探索。本文对多氯联苯的代谢途径、羟基多氯联苯在生物体内的暴露水平、雌激素干扰效应及作用机制进行综述。

关键词(KeyWords)： 羟基多氯联苯;代谢;雌激素效应

Abstract:

Keywords:

基金项目(Foundation): “国家重点研发计划”(2017YFC1600300)

作者(Author): 黄苑;苏晓鸥;王瑞国;张维;

Email:

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