王法琦;刘薇;金一和;于文广;刘晓晖;刘力;

• 1:大连理工大学环境与生命学院
• 2:中国医科大学公共卫生学院

摘要(Abstract)：

为了阐明PFOS导致新生儿死亡的可能原因和机制,探讨PFOS致死与神经系统发育的相互联系,利用基因芯片技术,观察了经PFOS饲料染毒后出生1和7d大鼠脑组织基因表达情况,通过基因组学(Gene Ontology)和生物路径(Pathway)对差异基因的功能和相互联系进行分析.结果显示,PFOS染毒后,出生1、7d的大鼠脑皮质组织分别有864、642条基因发生差异表达,差异基因涉及的与PFOS致死相关的生物过程包括中枢神经系统发育、血循环系统、刺激应答、骨骼发育、氧化应激、心脏功能以及pH值调节等.结果表明,PFOS导致的出生早期死亡与神经系统发育有关,PFOS可能通过改变脑组织血氧平衡,影响正常的中枢神经系统功能和发育过程而使新生儿的存活率下降.

关键词(KeyWords)： 全氟辛烷磺酸;出生早期死亡;基因芯片;发育神经毒性

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(No.30771772)

作者(Author): 王法琦;刘薇;金一和;于文广;刘晓晖;刘力;

Email:

DOI:

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