部分含J-型剂量-效应关系二元混合物的毒性效应Toxicities of Binary Mixtures Including at Least One Component with J-Shaped Dose-Response Curve
窦容妮;刘树深;刘海玲;王丽娟;覃礼堂;
摘要(Abstract):
低剂量刺激高剂量抑制的Hormesis效应常常呈现J-型剂量-效应关系,如何评价Hormesis污染物及其混合物的毒性目前尚未解决.选择微板毒性分析法(Microplate Toxicity Analysis,MTA)获得的具有J-型剂量-效应关系的丙酮、乙腈及S-型剂量效应关系的二甲亚砜为混合物组分,以直接均分射线法构建丙酮-二甲亚砜(J-S型)、乙腈-二甲亚砜(J-S型)和丙酮-乙腈(J-J型)3个二元混合物体系,利用不同效应浓度水平下以浓度加和为参考模型的多个等效线图分析污染物的毒性变化规律.结果表明,所有二元混合物仍然具有J-型浓度-效应关系特征,除丙酮-乙腈二元混合体系在1个效应浓度水平下可能呈现协同特征外,其余二元混合物在不同效应浓度水平均表现为拮抗特征.
关键词(KeyWords): J-型剂量-效应关系;直接均分射线法(EquRay);浓度加和;等效线图;拮抗
基金项目(Foundation): 国家自然科学基金项目(No.20777056);; 长江水环境教育部重点实验室自主研究课题(No.YRWEY1002)
作者(Author): 窦容妮;刘树深;刘海玲;王丽娟;覃礼堂;
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参考文献(References):
- Altenburger R,Nendza M,Schuurmann G.2003.Mixture toxicityand its modeling by quantitative structure-activity relationships[J].Environmental Toxicology and Chemistry,22(8):1900-1915
- Belz R G,Cedergreen N,Srensen H.2008.Hormesis in mixtures-Can it be predicted?[J].Science of the Total Environment,404(1):77-87
- Calabrese E J,Baldwin L A.2002.Defining hormesis[J].Human&Experimental Toxicology,21(1):91-97
- Calabrese E J,Baldwin L A.2003a.The hormetic dose-responsemodel is more common than the threshold model in toxicology[J].Toxicological Sciences,71(2):246-250
- Calabrese E J,Baldwin L A.2003b.Toxicology rethinks itscentral belief-Hormesis demands a reappraisal of the way risksare assessed[J].Nature,421(6924):691-692
- Calabrese E J,Baldwin L A,Holland C D.1999.Hormesis:Ahighly generalizable and reproducible phenomenon with importantimplications for risk assessment[J].Risk Analysis,19(2):261-281
- Cook R,Calabrese E J.2006.The importance of hormesis topublic health[J].Environmental Health Perspectives,114(11):1631-1635
- Faust M,Altenburger R,Backhaus T,Blanck H,Boedeker W,Gramatica P,Hamer V,Scholze M,Vighi M,Grimme L H.2001.Predicting the joint algal toxicity of multi-component s-triazine mixtures at low-effect concentrations of individual toxicants[J].Aquatic Toxicology,56(1):13-32
- Faust M,Altenburger R,Backhaus T,Blanck H,Boedeker W,Gramatica P,Hamer V,Scholze M,Vighi M,Grimme L H.2003.Joint algal toxicity of16dissimilarly acting chemicals ispredictable by the concept of independent action[J].AquaticToxicology,63(1):43-63
- Ge H L,Liu S S,Liu F.2006.Inhibition toxicity of mixturesof substituted anilines to photobacteria[J].Asian Journal ofEcotoxicology,1(4):295-302(in Chinese)
- Gennings C,Carter W H,Casey M,Moser V,Carchman R,Simmons J E.2004.Analysis of functional effects of a mixtureof five pesticides using a ray design[J].Environmental Toxicologyand Pharmacology,18(2):115-125
- Gessner P K.1995.Isobolographic analysis of interactions:anupdate on applications and utility[J].Toxicology,105(2-3):161-179
- Liu B Q,Ge H L,Liu S S.2006.Microplate luminometry fortoxicity bioassays of environmental pollutant on a new type offresh water luminescent bacterium(Vibiro-qinghaiensis sp.-Q67)[J].Asian Journal of Ecotoxicology,1(2):186-191(in Chinese)
- Liu S S,Liu F,Liu H L.2007.Toxicities of20kinds water-soluble organic solvents to(Vibiro-qinghaiensis sp.-Q67)[J].China Environmental Science,27(3):371-376(in Chinese)
- Liu S S,Song X Q,Liu H L,Zhang Y H,Zhang J.2009.Combined photobacterium toxicity of herbicide mixtures containingone insecticide[J].Chemosphere,75(3):381-388
- Qin L T,Liu S S,Liu H L,Zhang Y H.2010.Support vectorregression and least squares support vector regression for hormeticdose-response curves fitting[J].Chemosphere,78(3):327-334
- Stebbing A R D.1998.A theory for growth hormesis[J].Mutation Research-Fundamental and Molecular Mechanisms ofMutagenesis,403(1-2):249-258
- Stebbing A R D.2003.A mechanism for hormesis-A problemin the wrong discipline[J].Critical Reviews in Toxicology,33(3-4):463-467
- Suck W A,Olden K,Yang R S H.2002.Chemical mixturesresearch:significance and future perspectives[J].EnvironmentalHealth Perspective,110(S6):891-892
- Syberga K,Elleby A,Pedersen H,Cedergreen N,Forbes V E.2008.Mixture toxicity of three toxicants with similar anddissimilar modes of action to Daphnia magna[J].Ecotoxicologyand Environmental Safety,69(3):428-436
- Tong J,Feng Z Y.1994.Joint Action of Environmental Chemicals[M].Shanghai:Shanghai Science Press(in Chinese)
- Wang D H,Peng A,Wang Z J.2004.Advances in study ofhormesis[J].Journal of Safety and Environment,4(1):18-21(in Chinese)
- Zhang J,Liu S S,Liu H L.2009.Effect of ionic liquid on thetoxicity of pesticide to Vibrio-qinghaiensis sp-Q67[J].Journalof Hazardous Materials,170(2-3):920-927
- Zhang J,Wang J C,Liu S S,Ge H L,Liu H L.2009.Studyon the toxicity interaction between dimethoate and C16H31ClN2bycentral composite design with fixed concentration ratio ray[J].Asian Journal of Ecotoxicology,4(3):353-358(in Chinese)
- 葛会林,刘树深,刘芳.2006.多组分苯胺类混合物对发光菌的抑制毒性[J].生态毒理学报1(4):295-302
- 刘保奇,葛会林,刘树深.2006.测定环境污染物对青海弧菌发光强度抑制的微板发光法研究[J].生态毒理学报,1(2):186-191
- 刘树深,刘芳,刘海玲.2007.20种水溶性有机溶剂对发光菌的毒性效应[J].中国环境科学,27(3):371-376
- 童建,冯志英.1994.环境化学的联合作用[M].上海:上海科学技术文献出版社
- 王东红,彭安,王子健.2004.有毒物质低剂量刺激作用的研究进展[J].安全与环境学报,4(1):18-21
- 张晶,王金承,刘树深,葛会林,刘海玲.2009.中心复合设计射线法考察离子液体C16H31ClN2与乐果的毒性相互作用[J].生态毒理学报,4(3):353-358