部分含J-型剂量-效应关系二元混合物的毒性效应Toxicities of Binary Mixtures Including at Least One Component with J-Shaped Dose-Response Curve
窦容妮;刘树深;刘海玲;王丽娟;覃礼堂;
摘要(Abstract)：
低剂量刺激高剂量抑制的Hormesis效应常常呈现J-型剂量-效应关系,如何评价Hormesis污染物及其混合物的毒性目前尚未解决.选择微板毒性分析法(Microplate Toxicity Analysis,MTA)获得的具有J-型剂量-效应关系的丙酮、乙腈及S-型剂量效应关系的二甲亚砜为混合物组分,以直接均分射线法构建丙酮-二甲亚砜(J-S型)、乙腈-二甲亚砜(J-S型)和丙酮-乙腈(J-J型)3个二元混合物体系,利用不同效应浓度水平下以浓度加和为参考模型的多个等效线图分析污染物的毒性变化规律.结果表明,所有二元混合物仍然具有J-型浓度-效应关系特征,除丙酮-乙腈二元混合体系在1个效应浓度水平下可能呈现协同特征外,其余二元混合物在不同效应浓度水平均表现为拮抗特征.
关键词(KeyWords)： J-型剂量-效应关系;直接均分射线法(EquRay);浓度加和;等效线图;拮抗
基金项目(Foundation): 国家自然科学基金项目(No.20777056);; 长江水环境教育部重点实验室自主研究课题(No.YRWEY1002)
作者(Author): 窦容妮;刘树深;刘海玲;王丽娟;覃礼堂;
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