付铠;周启星;胡献刚;

• 1:南开大学环境科学与工程学院环境污染过程与基准教育部重点实验室天津市城市生态环境修复与污染防治重点实验室

摘要(Abstract)：

近些年,我国大气颗粒物所带来的健康问题越发突出,由此产生的环境疾病日益引起人们的广泛关注。大量的流行病学和毒理学研究发现,大气颗粒物能引起呼吸系统、心血管系统、神经系统、免疫系统等的损伤,造成新生儿出生缺陷,增加罹患癌症的风险,且与人群发病率和死亡率上升有关。但是由于大气颗粒物物化属性比较复杂,一种或几种损伤机制并不能完全解释其与致病效应的关系,因此具体的损伤机制目前还没有统一的说法,大气颗粒物物理化学属性与致病效应的关系仍在探索当中。本文从大气颗粒物的粒径、浓度、比表面积、来源、成分等基本属性入手,剖析其基本特点和可能影响健康的原因,探讨大气颗粒物通过氧化损伤途径诱导致病效应,并结合当前大气颗粒物健康影响研究现状提出在未来研究中应注重的相关内容。

关键词(KeyWords)： 颗粒物;环境疾病;损伤机制;氧化损伤;ROS;PM2.5

Abstract:

Keywords:

基金项目(Foundation): 教育部“污染生态化学”创新团队(IRT13024)基金项目;; 美国国家地理学会基金项目

作者(Author): 付铠;周启星;胡献刚;

Email:

参考文献(References)：

• [1]Breysse P N,Delfino R J,Dominici F,et al.US EPA particulate matter research centers:Summary of research results for 2005-2011[J].Air Quality Atmosphere and Health,2013,6(2):333-355
• [2]Lu S,Feng M,Yao Z,et al.Physicochemical characterization and cytotoxicity of ambient coarse,fine,and ultrafine particulate matters in Shanghai atmosphere[J].Atmospheric Environment,2011,45(3):736-744
• [3]Bzdek B R,Pennington M R,Johnston M V.Single particle chemical analysis of ambient ultrafine aerosol:A review[J].Journal of Aerosol Science,2012,52:109-120
• [4]Kumar P,Robins A,Vardoulakis S,et al.Technical challenges in tackling regulatory concerns for urban atmospheric nanoparticles[J].Particuology,2011,9(6):566-571
• [5]Loomis D,Grosse Y,Lauby-Secretan B,et al.The carcinogenicity of outdoor air pollution[J].Lancet Oncology,2013,14(13):1262-1263
• [6]Kunzi L,Mertes P,Schneider S,et al.Responses of lung cells to realistic exposure of primary and aged carbonaceous aerosols[J].Atmospheric Environment,2013,68:143-150
• [7]Ho M,Wu K Y,Chein H M,et al.Pulmonary toxicity of inhaled nanoscale and fine zinc oxide particles:Mass and surface area as an exposure metric[J].Inhalation Toxicology,2011,23(14):947-956
• [8]Hussain S,Boland S,Baeza-Squiban A,et al.Oxidative stress and proinflammatory effects of carbon black and titanium dioxide nanoparticles:Role of particle surface area and internalized amount[J].Toxicology,2009,260(1-3):142-149
• [9]Martins L D,Martins J A,Freitas E D,et al.Potential health impact of ultrafine particles under clean and polluted urban atmospheric conditions:A model-based study[J].Air Quality Atmosphere and Health,2010,3(1):29-39
• [10]Chien L C,Alamgir H,Yu H L.Spatial vulnerability of fine particulate matter relative to the prevalence of diabetes in the United States[J].Science of the Total Environment,2015,508:136-144
• [11]Mirowsky J E,Jin L,Thurston G,et al.In vitro and in vivo toxicity of urban and rural particulate matter from California[J].Atmospheric Environment,2015,103:256-262
• [12]Osornio-Vargas A R,Serrano J,Rojas-Bracho L,et al.In vitro biological effects of airborne PM2.5and PM10from a semi-desert city on the Mexico-US border[J].Chemosphere,2011,83(4):618-626
• [13]Just B,Rogak S,Kandlikar M.Characterization of ultrafine particulate matter from traditional and improved biomass cookstoves[J].Environmental Science&Technology,2013,47(7):3506-3512
• [14]Heal M R,Kumar P,Harrison R M.Particles,air quality,policy and health[J].Chemical Society Reviews,2012,41(19):6606-6630
• [15]Cyrys J,Peters A,Soentgen J,et al.Low emission zones reduce PM10mass concentrations and diesel soot in German cities[J].Journal of the Air&Waste Management Association,2014,64(4):481-487
• [16]Price H D,Jones T P,Beru Be K A.Resolution of the mediators of in vitro oxidative reactivity in size-segregated fractions that may be masked in the urban PM10cocktail[J].Science of the Total Environment,2014,485:588-595
• [17]Wang J,Hu Z,Chen Y,et al.Contamination characteristics and possible sources of PM10and PM2.5in different functional areas of Shanghai,China[J].Atmospheric Environment,2013,68:221-229
• [18]Chen R,Kan H,Chen B,et al.Association of particulate air pollution with daily mortality[J].American Journal of Epidemiology,2012,175(11):1173-1181
• [19]Sorensen M,Autrup H,Hertel O,et al.Personal exposure to PM2.5and biomarkers of DNA damage[J].Cancer Epidemiology Biomarkers&Prevention,2003,12(3):191-196
• [20]Bernatsky S,Fournier M,Pineau C A,et al.Associations between ambient fine particulate levels and disease activity in patients with systemic lupus erythematosus(SLE)[J].Environmental Health Perspectives,2011,119(1):45-49
• [21]Kumar P,Gurjar B R,Nagpure A S,et al.Preliminary estimates of nanoparticle number emissions from road vehicles in megacity delhi and associated health impacts[J].Environmental Science&Technology,2011,45(13):5514-5521
• [22]Karottki D G,Spilak M,Frederiksen M,et al.Indoor and outdoor exposure to ultrafine,fine and microbiologically derived particulate matter related to cardiovascular and respiratory effects in a panel of Elderly Urban Citizens[J].International Journal of Environmental Research and Public Health,2015,12(2):1667-1686
• [23]Strak M,Janssen N A H,Godri K J,et al.Respiratory health effects of airborne particulate matter:The role of particle size,composition,and oxidative potential-the RAPTES project[J].Environmental Health Perspectives,2012,120(8):1183-1189
• [24]Chow J C,Watson J G,Mauderly J L,et al.Health effects of fine particulate air pollution:Lines that connect[J].Journal of the Air&Waste Management Association,2006,56(10):1368-1380
• [25]Stoeger T,Reinhard C,Takenaka S,et al.Instillation of six different ultrafine carbon particles indicates a surface area threshold dose for acute lung inflammation in mice[J].Environmental Health Perspectives,2006,114(3):328-333
• [26]Notter D A.Life cycle impact assessment modeling for particulate matter:A new approach based on physico-chemical particle properties[J].Environment International,2015,82:10-20
• [27]van Berlo D,Hullmann M,Schins R P F.Toxicology of Ambient Particulate Matter[M].Molecular,Clinical and Environmental Toxicology,2012,101:165-217
• [28]Boman B C,Forsberg A B,Jarvholm B G.Adverse health effects from ambient air pollution in relation to residential wood combustion in modern society[J].Scandinavian Journal of Work Environment&Health,2003,29(4):251-260
• [29]Oberdorster G,Gelein R M,Ferin J,et al.Association of particulate air pollution and acute mortality:Involvement of ultrafine particles?[J].Inhalation Toxicology,1995,7(1):111-124
• [30]Castro A,Calvo A I,Alves C,et al.Indoor aerosol size distributions in a gymnasium[J].Science of the Total Environment,2015,524:178-186
• [31]Oberdorster G,Maynard A,Donaldson K,et al.Principles for characterizing the potential human health effects from exposure to nanomaterials:Elements of a screening strategy[J].Particle and Fibre Toxicology,2005,2:8-8
• [32]O'Shaughnessy P T.Occupational health risk to nanoparticulate exposure[J].Environmental Science-Processes&Impacts,2013,15(1):49-62
• [33]Chuang H C,Chen L C,Lei Y C,et al.Surface area as a dose metric for carbon black nanoparticles:A study of oxidative stress,DNA single-strand breakage and inflammation in rats[J].Atmospheric Environment,2015,106:329-334
• [34]Topinka J,Milcova A,Schmuczerova J,et al.Ultrafine particles are not major carriers of carcinogenic PAHs and their genotoxicity in size-segregated aerosols[J].Mutation Research-Genetic Toxicology and Environmental Mutagenesis,2013,754(1-2):1-6
• [35]Oh S M,Kim H R,Park Y J,et al.Organic extracts of urban air pollution particulate matter(PM2.5)-induced genotoxicity and oxidative stress in human lung bronchial epithelial cells(BEAS-2B cells)[J].Mutation ResearchGenetic Toxicology and Environmental Mutagenesis,2011,723(2):142-151
• [36]Kelly F J,Fussell J C.Size,source and chemical composition as determinants of toxicity attributable to ambient particulate matter[J].Atmospheric Environment,2012,60:504-526
• [37]Sanderson P,Delgado-Saborit J M,Harrison R M.A review of chemical and physical characterisation of atmospheric metallic nanoparticles[J].Atmospheric Environment,2014,94:353-365
• [38]Bell M L,Belanger K,Ebisu K,et al.Prenatal exposure to fine particulate matter and birth weight variations by particulate constituents and sources[J].Epidemiology,2010,21(6):884-891
• [39]Wu S,Deng F,Hao Y,et al.Chemical constituents of fine particulate air pollution and pulmonary function in healthy adults:The healthy volunteer natural relocation study[J].Journal of Hazardous Materials,2013,260:183-191
• [40]Tapanainen M,Jalava P I,Maki-Paakkanen J,et al.In vitro immunotoxic and genotoxic activities of particles emitted from two different small-scale wood combustion appliances[J].Atmospheric Environment,2011,45(40):7546-7554
• [41]Taner S,Pekey B,Pekey H.Fine particulate matter in the indoor air of barbeque restaurants:Elemental compositions,sources and health risks[J].Science of the Total Environment,2013,454:79-87
• [42]Michael S,Montag M,Dott W.Pro-inflammatory effects and oxidative stress in lung macrophages and epithelial cells induced by ambient particulate matter[J].Environmental Pollution,2013,183:19-29
• [43]Libalova H,Uhlirova K,Klema J,et al.Global gene expression changes in human embryonic lung fibroblasts induced by organic extracts from respirable air particles[J].Particle and Fibre Toxicology,2012,9:1
• [44]Yi S,Zhang F,Qu F,et al.Water-insoluble fraction of airborne particulate matter(PM10)induces oxidative stress in human lung epithelial A549 Cells[J].Environmental Toxicology,2014,29(2):226-233
• [45]Franklin M,Koutrakis P,Schwartz J.The role of particle composition on the association between PM2.5and mortality[J].Epidemiology,2008,19(5):680-689
• [46]Wingfors H,Hagglund L,Magnusson R.Characterization of the size-distribution of aerosols and particle-bound content of oxygenated PAHs,PAHs,and n-alkanes in urban environments in Afghanistan[J].Atmospheric Environment,2011,45(26):4360-4369
• [47]Vilcassim M J R,Thurston G D,Peltier R E,et al.Black carbon and particulate matter(PM2.5)concentrations in New York city's subway stations[J].Environmental Science&Technology,2014,48(24):14738-14745
• [48]Zhu C S,Cao J J,Tsai C J,et al.Comparison and implications of PM2.5carbon fractions in different environments[J].Science of the Total Environment,2014,466:203-209
• [49]Chen S Y,Lin Y L,Chang W T,et al.Increasing emergency room visits for stroke by elevated levels of fine particulate constituents[J].Science of the Total Environment,2014,473:446-450
• [50]Faiola C,Johansen A M,Rybka S,et al.Ultrafine particulate ferrous iron and anthracene associations with mitochondrial dysfunction[J].Aerosol Science and Technology,2011,45(9):1109-1122
• [51]Andreau K,Ferecatu I,Leroux M,et al.Polycyclic aromatic hydrocarbon components contribute to the mitochondria-antiapoptotic effect of fine particulate matter on human bronchial epithelial cells via the aryl hydrocarbon receptor[J].Toxicology Letters,2011,205:S180-S180
• [52]Reche C,Querol X,Alastuey A,et al.New considerations for PM,black carbon and particle number concentration for air quality monitoring across different European cities[J].Atmospheric Chemistry and Physics,2011,11(13):6207-6227
• [53]Janssen N A H,Hoek G,Simic-Lawson M,et al.Black carbon as an additional indicator of the adverse health effects of airborne particles compared with PM10and PM2.5[J].Environmental Health Perspectives,2011,119(12):1691-1699
• [54]Hua J,Yin Y,Peng L,et al.Acute effects of black carbon and PM2.5on children asthma admissions:A time-series study in a Chinese city[J].Science of the Total Environment,2014,481:433-438
• [55]Jung K H,Hsu S I,Yan B,et al.Childhood exposure to fine particulate matter and black carbon and the development of new wheeze between ages 5 and 7 in an urban prospective cohort[J].Environment International,2012,45:44-50
• [56]Saputra D,Yoon J H,Park H,et al.Inhalation of carbon black nanoparticles aggravates pulmonary inflammation in mice[J].Toxicological Research,2014,30(2):83-90
• [57]Rai S,Gupta S,Mittal P C.Dietary intakes and health risk of toxic and essential heavy metals through the food chain in agricultural,industrial,and coal mining areas of northern India[J].Human and Ecological Risk Assessment,2015,21(4):913-933
• [58]Cakmak S,Dales R,Kauri L M,et al.Metal composition of fine particulate air pollution and acute changes in cardiorespiratory physiology[J].Environmental Pollution,2014,189:208-214
• [59]Huang H B,Chen G W,Wang C J,et al.Exposure to heavy metals and polycyclic aromatic hydrocarbons and DNA damage in Taiwanese traffic conductors[J].Cancer Epidemiology Biomarkers&Prevention,2013,22(1):102-108
• [60]Zhou P,Guo J,Zhou X,et al.PM2.5,PM10and health risk assessment of heavy metals in a typical printed circuit noards manufacturing workshop[J].Journal of Environmental Sciences-China,2014,26(10):2018-2026
• [61]Di Pietro A,Baluce B,Visalli G,et al.Ex vivo study for the assessment of behavioral factor and gene polymorphisms in individual susceptibility to oxidative DNA damage metals-induced[J].International Journal of Hygiene and Environmental Health,2011,214(3):210-218
• [62]Han Y M,Cao J J,Jin Z D,et al.Elemental composition of aerosols in Daihai,a rural area in the front boundary of the summer Asian monsoon[J].Atmospheric Research,2009,92(2):229-235
• [63]Wu S,Deng F,Wang X,et al.Association of lung function in a panel of young healthy adults with various chemical components of ambient fine particulate air pollution in Beijing,China[J].Atmospheric Environment,2013,77:873-884
• [64]Satsangi P G,Yadav S,Pipal A S,et al.Characteristics of trace metals in fine(PM2.5)and inhalable(PM10)particles and its health risk assessment along with in-silico approach in indoor environment of India[J].Atmospheric Environment,2014,92:384-393
• [65]Zhang T,Cao J J,Tie X X,et al.Water-soluble ions in atmospheric aerosols measured in Xi'an,China:Seasonal variations and sources[J].Atmospheric Research,2011,102(1-2):110-119
• [66]Hu G Y,Zhang Y M,Sun J Y,et al.Variability,formation and acidity of water-soluble ions in PM2.5in Beijing based on the semi-continuous observations[J].Atmospheric Research,2014,145:1-11
• [67]Gwynn R C,Burnett R T,Thurston G D.A time-series analysis of acidic particulate matter and daily mortality and morbidity in the Buffalo,New York,region[J].Environmental Health Perspectives,2000,108(2):125-133
• [68]Wellenius G A,Diaz E A,Gupta T,et al.Electrocardiographic and respiratory responses to coal-fired power plant emissions in a rat model of acute myocardial infarction:Results from the toxicological evaluation of realistic emissionsof source aerosols study[J].Inhalation Toxicology,2011,23:84-94
• [69]Hazi Y,Heikkinen M S A,Cohen B S.Size distribution of acidic sulfate ions in fine ambient particulate matter and assessment of source region effect[J].Atmospheric Environment,2003,37(38):5403-5413
• [70]Reiss R,Anderson E L,Cross C E,et al.Evidence of health impacts of sulfate-and nitrate-containing particles in ambient air[J].Inhalation Toxicology,2007,19(5):419-449
• [71]Yang A,Jedynska A,Hellack B,et al.Measurement of the oxidative potential of PM2.5and its constituents:The effect of extraction solvent and filter type[J].Atmospheric Environment,2014,83:35-42
• [72]Jacobi H W,Kleffmann J,Villena G,et al.Role of nitrite in the photochemical formation of radicals in the snow[J].Environmental Science&Technology,2014,48(1):165-172
• [73]Wang D,Pakbin P,Shafer M M,et al.Macrophage reactive oxygen species activity of water-soluble and water-insoluble fractions of ambient coarse,PM2.5and ultrafine particulate matter(PM)in Los Angeles[J].Atmospheric Environment,2013,77:301-310
• [74]Donaldson K,Stone V,Borm P J A,et al.Oxidative stress and calcium signaling in the adverse effects of environmental particles(PM10)[J].Free Radical Biology and Medicine,2003,34(11):1369-1382
• [75]Wei Y,Han I K,Shao M,et al.PM2.5constituents and oxidative DNA damage in humans[J].Environmental Science&Technology,2009,43(13):4757-4762
• [76]Xiong Q,Ru Q,Chen L,et al.Combined effects of fine particulate matter and lipopolysaccharide on apoptotic responses in NR8383 macrophages[J].Journal of Toxicology and Environmental Health,2015,78(7):443-452
• [77]Cui Y,Xie X,Jia F,et al.Ambient fine particulate matter induces apoptosis of endothelial progenitor cells through reactive oxygen species formation[J].Cell Physiol Biochem,2015,35(1):353-363