5种取代酚化合物对淡水发光菌的联合毒性Joint Toxicity of 5 Substituted Phenols to Freshwater Photobacteria
莫凌云;刘海玲;刘树深;张天生;刘保奇;葛会林;
摘要(Abstract)：
以新型淡水发光菌——青海弧菌Q67(Vibrio-qinghaiensissp.—Q67)为检验生物,以VeritasTM微孔板光度计为发光强度测试设备,分别测定了3,5-二羟基甲苯、2,3-二甲基苯酚、对氯苯酚、邻氯苯酚、2,4-二氯苯酚对淡水发光菌的发光抑制毒性及其混合物的联合毒性.结果表明,5种取代酚的剂量-效应关系都可用Weibull模型有效描述,从这些模型估算的半数效应浓度负对数值(-logEC50)分别为2.69、3.08、3.43、2.81和3.66,可知其对发光菌的毒性大小顺序为:2,4-二氯苯酚>对氯苯酚>2,3-二甲基苯酚>邻氯苯酚>3,5-二羟基甲苯.分别设计浓度等于各自之EC50和EC10的2个等效应浓度比混合物以及3个不同效应浓度比混合物进行联合毒性实验,结果发现,在所实验的浓度范围内各个混合物的剂量加和(DA)模型与独立作用(IA)模型具有相似的作用规律,其联合毒性既可用DA模型也可用IA模型进行预测.
关键词(KeyWords)： 淡水发光菌;酚类化合物;联合毒性;剂量加和;独立作用
基金项目(Foundation): 全国优秀博士学位论文作者基金项目(No.200355);; 国家自然科学基金项目(No.20577023);; 上海市重点基础研究计划(No.06JC14067)
作者(Author): 莫凌云;刘海玲;刘树深;张天生;刘保奇;葛会林;
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