张旻;胡燕平;宋捷;王雪;王秀文;李波;

• 1:中国药品生物制品检定所国家药物安全评价监测中心

摘要(Abstract)：

为检测高效光引发剂4,4′-二甲基二苯基碘鎓盐六氟磷酸盐(IHT-PI820)和2-异丙基硫杂蒽酮(IHT-PIITX)的染色体畸变作用,采用体外培养中国仓鼠肺成纤维细胞(CHL)染色体畸变实验,在代谢活化与非代谢活化条件下,观察PI820及ITX致CHL细胞株染色体数目及结构的变化.结果显示:在非代谢活化条件下,PI820引起CHL细胞多倍体增加,并具有剂量反应关系,在代谢活化条件下未见对CHL细胞染色体有损伤作用;在代谢活化与非代谢活化条件下,均未观察到ITX对CHL细胞染色体的损伤作用.PI820可引起CHL细胞染色体数目畸变,ITX无染色体畸变作用.

关键词(KeyWords)： 4,4′-二甲基二苯基碘鎓盐六氟磷酸盐(IHT-PI820);2-异丙基硫杂蒽酮(IHT-PIITX);染色体畸变

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 张旻;胡燕平;宋捷;王雪;王秀文;李波;

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