王洪芳;赵飞;王蔚;汝少国;

• 1:中国海洋大学海洋生命学院

摘要(Abstract)：

内分泌干扰物(endocrine disrupting chemicals,EDCs)可以从不同来源释放到环境中,近年来动物实验研究表明,多种EDCs能够破坏生命早期胰腺发育,增加成年期患代谢疾病的风险,但其潜在机制尚不完全清楚。本文总结了近年来EDCs对不同动物模型胰腺发育的影响,主要包括胰岛β细胞结构损伤、胰岛β细胞功能障碍、胰岛尺寸降低、胰岛畸形、次级胰岛形成延迟以及胰腺长度缩短等,并从转录因子、氧化应激以及表观遗传修饰等方面对其作用机制进行综述,以期为EDCs健康风险评估提供参考。

关键词(KeyWords)： 内分泌干扰物;胰腺发育;胰岛β细胞

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目(No.41676100)

作者(Author): 王洪芳;赵飞;王蔚;汝少国;

Email:

DOI:

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