涕灭威及其有毒代谢产物对DNA潜在损伤研究The Research of Aldicarb and It's Toxic Metabolites on DNA Potential Harm
宋艳;朱鲁生;王军;谢慧;刘伟;王秀国;王倩;钱博;
摘要(Abstract)：
采用生物遗传监测系统,研究了涕灭威及其两个有毒代谢产物(涕灭威亚砜,涕灭威砜)对蚕豆及大蒜根尖细胞微核率的影响,以及对小牛胸腺DNA的加合作用．结果表明,两种植物根尖细胞微核试验测得的高浓度剂量诱导的微核率与对照组相比有显著性差异(p<0．05),说明涕灭威、涕灭威亚砜及涕灭威砜可能对蚕豆及大蒜根尖细胞有致突变性．并且配对资料差异的显著性检验表明,蚕豆根尖微核试验的敏感性明显高于大蒜根尖微核试验的敏感性．涕灭威及其两个有毒代谢产物与小牛胸腺DNA结合引起吸收光谱波峰的移位,而且存在着剂量关系,说明涕灭威、涕灭威亚砜及涕灭威砜可能对小牛胸腺DNA造成加合作用．
关键词(KeyWords)： 涕灭威;涕灭威亚砜;涕灭威砜;微核试验;DNA加合
基金项目(Foundation): 国家自然科学基金(No．20477022);; 山东省优秀中青年科学家科研奖励基金(No．03BS123)
作者(Author): 宋艳;朱鲁生;王军;谢慧;刘伟;王秀国;王倩;钱博;
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