联苯胺类化合物对斑马鱼胚胎发育毒性的初步研究Preliminary Study on Zebrafish Embryo-toxicity of Benzidine Congeners
刘红玲;于红霞;姜威;王晓蓉;史淑洁;朱琳;
摘要(Abstract)：
应用斑马鱼胚胎发育技术,对4种联苯胺类化合物(联苯胺、3,3'-二甲氧基联苯胺、3,3'-二甲基联苯胺、3,3'-二氯联苯胺)的毒性进行了测定.结果表明,这4种化合物对斑马鱼胚胎发育均有明显抑制作用,可以造成仔鱼畸形甚至死亡,具有特定的最敏感毒理学终点及作用时间;联苯胺苯环上的取代基可以增强联苯胺的亲电作用或亲核作用,从而增强其胚胎毒性,其中尤以卤代产物(3,3'-二氯联苯胺)最为显著.其毒性排列顺序大致为:3,3'-二氯联苯胺>3,3'-二甲基联苯胺>3,3'-二甲氧基联苯胺>联苯胺;4种联苯胺的斑马鱼胚胎毒性数据与lgKow没有显著相关性,推测这4种联苯胺的毒性机理属体内反应型,毒物参与生理代谢.
关键词(KeyWords)： 联苯胺;斑马鱼(Brachydanio rerio);胚胎发育;毒性
基金项目(Foundation): 国家自然科学基金重点项目(No.20237010);; 国家自然科学基金面上项目(No.20375015)
作者(Author): 刘红玲;于红霞;姜威;王晓蓉;史淑洁;朱琳;
Email:
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