薛柯;许霞;薛银刚;穆云松;刘菲;江晓栋;施昕澜;顾铭;

• 1:常州大学环境与安全工程学院
• 2:江苏省环境保护水环境生物监测重点实验室江苏省常州环境监测中心
• 3:中国环境科学研究院环境基准与风险评估国家重点实验室
• 4:江苏理工学院化学与环境工程学院

摘要(Abstract)：

作为一种模式生物,斑马鱼具有很多优点,包括体积小、成本低、适应性广、繁殖周期短、胚胎透明且产卵量高等,因而被广泛应用于生态毒理学等领域。斑马鱼的生命阶段主要包括胚胎、仔鱼和成鱼3个阶段。近年来,斑马鱼全生命周期的毒理学研究所占比重不断上升并呈稳定增长的趋势。本文对斑马鱼3个生命阶段及整个生命周期的毒性试验展开综述,介绍了斑马鱼全生命周期实验在毒理学中的研究进展,总结了各生命阶段国内外的标准规范和资源库信息、毒理学终点及转基因斑马鱼的研究进展,归纳了多阶段毒性评价和整个生命周期毒性评价的应用。最后,对全生命周期和基于斑马鱼毒性测试的应用做出展望,对未来开展的相关研究提出建议。

关键词(KeyWords)： 斑马鱼;生命周期;毒性测试

Abstract:

Keywords:

基金项目(Foundation): 水体污染控制与治理科技重大专项(2017ZX07202-01);; 国家环境保护标准项目(2015-9);; 江苏省第十四批“六大人才高峰”项目(JNHB-118);; 常州市科技局科技支撑社会发展项目(CE20175022)

作者(Author): 薛柯;许霞;薛银刚;穆云松;刘菲;江晓栋;施昕澜;顾铭;

Email:

DOI:

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