任璐;方建章;龙飞;卢平;刘桂华;张建清;陆少游;

• 1:华南师范大学化学与环境学院
• 2:深圳市疾病预防控制中心

摘要(Abstract)：

对羟基苯甲酸酯是一种防腐剂和抑菌剂,广泛应用于食品、药品和化妆品等行业。研究已证实对羟基苯甲酸酯具有一定的生殖毒性、发育毒性以及雌激素活性。通过测定尿液中对羟基苯甲酸酯的含量,可综合地反映出人体对羟基苯甲酸酯的暴露情况。本研究采集66例广州市某幼儿园儿童尿样,采用高效液相色谱-串联质谱检测了其中对羟基苯甲酸甲酯、对羟基苯甲酸乙酯、对羟基苯甲酸丙酯、对羟基苯甲酸丁酯和对羟基苯甲酸苄酯等5种对羟基苯甲酸酯浓度水平。对羟基苯甲酸甲酯、对羟基苯甲酸乙酯和对羟基苯甲酸丙酯的中值浓度分别为4.42、1.39和1.74μg·L~(-1)。对羟基苯甲酸丁酯和对羟基苯甲酸苄酯检出率较低。本研究中广州市幼儿园儿童对羟基苯甲酸酯含量水平远低于欧美国家同龄儿童,而与印度同龄儿童水平相当。相关性分析显示,对羟基苯甲酸甲酯与对羟基苯甲酸丙酯呈一定程度的相关性,暗示二者可能有相同的来源。

关键词(KeyWords)： 对羟基苯甲酸酯;幼儿园儿童;尿样;暴露水平

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(41303094);; 广东省自然科学基金(2015A030313869);; 深圳市基础研究计划(JCYJ20140415091352816)

作者(Author): 任璐;方建章;龙飞;卢平;刘桂华;张建清;陆少游;

Email:

DOI:

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