韩倩;张丽娟;胡国成;于云江;甘炼;崔科;黄楚珊;

• 1:环境保护部华南环境科学研究所
• 2:国家环境保护饮用水水源地管理技术重点实验室深圳市饮用水水源地安全保障重点实验室深圳市环境科学研究院
• 3:华南农业大学

摘要(Abstract)：

十溴二苯乙烷(DBDPE)是目前在全球范围内广泛使用的新型溴代阻燃剂,其环境风险已引起广泛关注,但目前仍缺乏针对水生生物的毒性研究数据。作者通过饲料中添加十溴二苯乙烷暴露的方式对草鱼幼鱼进行长期暴露实验,研究500、1 000和3 000 mg·kg~(-1)三个饲料添加剂量暴露组和1个对照组长期暴露对草鱼幼鱼肝脏和肌肉组织中氧化应激酶(SOD、CAT和GSH-PX)活性和抗氧化物质(GSH)含量的影响。结果显示:暴露8周后,随着DBDPE暴露水平的升高,草鱼幼鱼肝脏组织中氧化应激酶(SOD、CAT和GSH-PX)和抗氧化物质(GSH)均表现出低浓度诱导及高浓度抑制的效应。500和1 000 mg·kg~(-1)剂量组草鱼幼鱼肝脏组织中SOD、CAT和GSH-PX活性和GSH含量均显著高于对照组(P<0.05),且均在500 mg·kg~(-1)剂量组达到最高。3 000 mg·kg~(-1)剂量组SOD、CAT和GSH-PX活性和GSH含量低于500和1 000 mg·kg~(-1)暴露组,但与对照组无显著性差异(P>0.05)。草鱼幼鱼肌肉组织中氧化应激酶活性变化甚微,3个浓度剂量组肌肉组织中SOD、CAT活性和GSH含量以及500 mg·kg~(-1)剂量组GSH-PX活性与对照组均无显著性差异(P>0.05)。研究成果表明DBDPE暴露影响草鱼幼鱼肝脏组织的抗氧化防御系统,可以诱导草鱼幼鱼产生氧化应激效应。

关键词(KeyWords)： 十溴二苯乙烷;草鱼幼鱼;氧化应激;肝脏;肌肉

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金青年基金(21107028,31202007);国家自然科学基金面上项目(21377045);; 广东省自然科学基金(2014A030310002)

作者(Author): 韩倩;张丽娟;胡国成;于云江;甘炼;崔科;黄楚珊;

Email:

DOI:

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