吴明和;周锡昌;梅秀丽;梅启明;郭鹏;

• 1:武汉大学生命科学学院
• 2:武汉大学园林与环卫中心
• 3:武汉大学药学院

摘要(Abstract)：

采用不同浓度(50、100、200mg·kg-1)的联苯胺(Benzidine)和不同浓度(200、400、800mg·kg-1)的六氯苯(1,2,3,4,5,6-Hexachlorocyclohexane),通过对大鼠进行体内染毒建立毒性作用动物模型,分析了大鼠肝脏线粒体抗氧化物酶及呼吸代谢和能量转换酶(SOD、GSH-Px、COX和Ca2+-ATPase、Mg2+-ATPase)活性的变化.结果表明,在低浓度联苯胺(50mg·kg-1)和六氯苯(200mg·kg-1或400mg·kg-1)作用下酶活性出现应激反应,而高浓度联苯胺(100、200mg·kg-1)和六氯苯(800mg·kg-1)则显示出明显的抑制作用.分析认为,联苯胺和六氯苯可能经体内代谢活化后,对线粒体DNA及其转录和翻译系统产生作用,导致线粒体代谢功能紊乱,这可能是联苯胺和六氯苯毒性作用对线粒体损伤的主要机制.

关键词(KeyWords)： 联苯胺;六氯苯;体内染毒;大鼠肝脏;线粒体酶

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(No.20177018)

作者(Author): 吴明和;周锡昌;梅秀丽;梅启明;郭鹏;

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