何庆峰;李宏;李燕杰;张平平;张爱琳;吴海清;

• 1:天津农学院食品科学与生物工程学院
• 2:福建卫生职业技术学院
• 3:天津农学院计算机与信息工程学院

摘要(Abstract)：

目前,针对双酚A(BPA)或镉(Cd)内分泌干扰毒性的研究很多,但是关于其联合作用的研究则较少。将昆明雌性幼鼠分为4组,分别为对照组、BPA组、Cd组及联合组,灌胃染毒5周,观察小鼠动情周期、卵巢组织抗氧化水平、血清性激素及子宫内膜下层α亚型雌激素受体(ERα)免疫组化表达等指标的变化。结果发现,与对照组比较,各染毒组的动情周期均发生变化,体重、子宫系数、血清性激素水平及子宫内膜下层ERα表达降低(P<0.05);BPA组及Cd组的卵巢T-SOD及MDA水平与对照组比较无差异(P>0.05),但联合组的卵巢T-SOD及MDA水平显著区别于对照组(P<0.05);此外,联合组的子宫内膜下层ERα阳性表达率(36%±11.7%)显著低于BPA组及Cd组(P<0.05)。BPA及Cd对雌性生殖内分泌系统联合作用毒性较各单剂量组增加,氧化损伤及影响ERα表达可能是联合毒性作用机制之一。

关键词(KeyWords)： 双酚A;镉;联合作用;雌性;生殖内分泌

Abstract:

Keywords:

基金项目(Foundation): 天津农学院教学改革项目(12-A2-03)

作者(Author): 何庆峰;李宏;李燕杰;张平平;张爱琳;吴海清;

Email:

DOI:

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