刘帅;胡磊;杨明;

• 1:上海大学环境与化学工程学院
• 2:上海大学生命科学学院

摘要(Abstract)：

环境雌激素进入生物体后,可通过多种方式介导发挥类似内源雌激素的作用,干扰生物体的正常功能,进而对生物体产生毒害作用。其中,基因组方式介导的雌激素效应主要通过与细胞核内的雌激素受体(如ERα和ERβ)结合;而非基因组方式介导的雌激素效应则主要通过与膜雌激素受体结合从而发挥作用。近年来对G蛋白偶联雌激素受体1(GPER1)的研究表明,该受体是区别于雌激素核受体的膜雌激素受体,可单独介导雌激素诱发的非基因组方式雌激素效应,然而目前对其介导的雌激素效应机制研究并不完善。综上,本文结合近年来对GPER1的研究进展,从该受体的发现、特性以及其介导的雌激素效应和相关通路进行了综述。

关键词(KeyWords)： 环境雌激素;膜雌激素受体;G蛋白偶联雌激素受体

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(No.31470554);; 上海市教委创新项目(No.14YZ001)

作者(Author): 刘帅;胡磊;杨明;

Email:

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