陈敏杰;黎丽莎;陈冯杰;刘钰晨;张捷;梁勇;刘继延;

• 1:江汉大学医学院
• 2:华中农业大学资源与环境学院
• 3:江汉大学环境与健康研究院
• 4:江汉大学光电化学材料与器件教育部重点实验室化学与环境工程学院

摘要(Abstract)：

二烷基次膦酸盐(DPs)作为一种新型有机磷阻燃剂正在被大量合成并应用,但关于其毒理学效应的研究还十分匮乏。研究者首次以斑马鱼胚胎作为实验模型,初步探讨了2种新型DPs阻燃剂甲基环己基次膦酸铝(AMHP)、甲基环己基次膦酸钙(CMHP)和2种已市场化生产的DPs阻燃剂甲基乙基次膦酸铝(AMEP)、二乙基次膦酸铝(ADEP)对鱼类的急性毒性效应。结果表明,AMHP和CMHP对斑马鱼胚胎无明显毒性效应;500 mg·L~(-1)的AMEP和ADEP能显著增加斑马鱼胚胎死亡率,降低其出膜率。AMHP和CMHP的水解产物甲基环己基次膦酸在浓度为1 000 mg·L~(-1)时,可使斑马鱼胚胎出膜率下降,并导致胚胎死亡,推测DPs的水解产物二烷基次膦酸是造成斑马鱼胚胎死亡的主要因素。进一步比较去除卵膜后,DPs对斑马鱼胚胎的毒性效应,发现DPs主要通过影响斑马鱼胚胎的出膜进而造成胚胎的死亡。上述研究结果从水生生物毒性的角度为DPs阻燃剂是否能作为溴化阻燃剂和传统有机磷阻燃剂的替代品提供了实验依据。

关键词(KeyWords)： 二烷基次膦酸盐;二烷基次膦酸;斑马鱼胚胎;毒性

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(21407063,21277062);; 武汉市晨光科技计划(2013071004010474);; 环境化学和生态毒理学国家重点实验室开放基金(KF2012-18,KF2013-08);; 江汉大学人才启动基金(2012031)

作者(Author): 陈敏杰;黎丽莎;陈冯杰;刘钰晨;张捷;梁勇;刘继延;

Email:

DOI:

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