岳宗豪;赵欢;周一兵;

• 1:大连海洋大学辽宁省海洋生物资源恢复与生境修复重点实验室

摘要(Abstract)：

已有研究发现多种酚类化合物可以干扰水生生物正常内分泌代谢,对生物生殖系统、神经系统、免疫系统等产生毒性效应,进而通过食物链的生物放大作用对人体产生危害。酚类化合物对生物体的内分泌干扰效应已经成为了近年来的研究热点。结合近年来国内外毒理学研究进展,在详细概述酚类化合物对水生生物的毒性效应及作用机制的基础上,并对目前研究中存在的问题以及未来的研究方向进行了探讨和展望。

关键词(KeyWords)： 酚类化合物;水生生物;毒性效应;作用机理

Abstract:

Keywords:

基金项目(Foundation): 国家海洋公益性行业科研专项经费(201305002,201305043);; 辽宁省教育厅科学研究一般项目(L2012269);; 国家自然科学基金(30901107)

作者(Author): 岳宗豪;赵欢;周一兵;

Email:

参考文献(References)：

• [1]赵美萍,李元宗,常文保.酚类环境雌激素的分析研究进展[J].分析化学,2003,31(1):103-109Zhao M P,Li Y Z,Chang W B.The analysis of phenolic environmental estrogens[J].Journal of Analytical Chemistry,2003,31(1):103-109(in Chinese)
• [2]Harley K G,Gunier R B,Kogut K,et al.Prenatal and early childhood bisphenol A concentrations and behavior in school-aged children[J].Environmental Research,2013,126,43-50
• [3]Brotons J A,Olea-Serrano M F,Villalobos M,et al.Xenoestrogens released from lacquer coatings in food cans[J].Environmental Health Perspectives,1995,103(6):608-612
• [4]Rocha M J,Cruzeiro C,Reis M,et al.Determination of seventeen endocrine disruptor compounds and their spatial and seasonal distribution in Ria Formosa Lagoon(Portugal)[J].Environmental Monitoring and Assessment,2013,185(10):8215-8226
• [5]Wu M,Wang L,Xu G,et al.Seasonal and spatial distribution of 4-tert-octylphenol,4-nonylphenol and bisphenol A in the Huangpu River and its tributaries,Shanghai,China[J].Environmental Monitoring and Assessment,2013,185(4):3149-3161
• [6]李正炎,傅明珠,王馨平,等.冬季胶州湾及其周边河流中酚类环境激素的分布特征[J].中国海洋大学学报,2006,36(3):451-455Li Z Y,Fu M Z,Wang X P,et al.Distribution of phenolic environmental hormones in Jiaozhou Bay and its adjacent rivers in winter[J].Periodical of Ocean University of China,2006,36(3):451-455(in Chinese)
• [7]褚春莹,但丽霞,蒋海威,等.胶州湾入海河流和排污口水体中壬基酚的污染状况调查及入海通量核算[J].中国环境监测,2013,29(2):29-33Chu C Y,Dan L X,Jiang H W,et al.Pollution status and flux of nonylphenol in the water of the rivers and drainage outlet entering the Jiaozhou Bay[J].Environmental Monitoring in China,2013,29(2):29-33(in Chinese)
• [8]董军,李向丽,梁锐杰,等.珠江口地区水体中双酚A污染及其与环境因子的关系[J].生态与农村环境学报,2009,25(2):94-97Dong J,Li X L,Liang R J.Bisphenol A pollution of surface water and its environmental factors[J].Journal of Ecology and Rural Environment,2009,25(2):94-97(in Chinese)
• [9]Gatidou G,Vassalou E,Thomaidis N S.Bioconcentration of selected endocrine disrupting compounds in the Mediterranean mussel,Mytilus galloprovincialis[J].Marine Pollution Bulletin,2010,60(11):2111-2116
• [10]Takahashi A,Higashitani T,Yakou Y,et al.Evaluating bioaccumulation of suspected endocrine disruptors into periphytons and benthos in the Tama River[J].Water Science and Technology,2003,47(9):71-76
• [11]Molina A M,Lora A J,Blanco A,et al.Endocrine-active compound evaluation:Qualitative and quantitative histomorphological assessment of zebrafish gonads after bisphenol-A exposure[J].Ecotoxicology and Environmental Safety,2013,88:155-162
• [12]Sayed Ael-D,Mahmoud U M,Mekkawy I A.Reproductive biomarkers to identify endocrine disruption in Clarias gariepinus exposed to 4-nonylphenol[J].Ecotoxicology and Environmental Safety,2012,78:310-319
• [13]Jespersen A,Rasmussen T H,Hirche M,et al.Effects of exposure to the xenoestrogen octylphenol and subsequent transfer to clean water on liver and gonad ultra-structure during early development of Zoarces viviparus embryos[J].Journal of Experimental Zoology Part A:Ecological Genetics and Physiology,2010,313(7):399-409
• [14]Jemec A,Ti ler T,Erjavec B,et al.Antioxidant responses and whole-organism changes in Daphnia magna acutely and chronically exposed to endocrine disruptor bisphenol A[J].Ecotoxicology and Environmental Safety,2012,86:213-218
• [15]Lam S H,Hlaing M M,Zhang X,et al.Toxicogenomic and phenotypic analyses of bisphenol-A early-life exposure toxicity in zebrafish[J].Plos One,2011,6(12):e28273
• [16]Matsushima A,Ryan K,Shimohigashi Y,et al.An endocrine disruptor,bisphenol A,affects development in the protochordate Ciona intestinalis:Hatching rates and swimming behavior alter in a dose-dependent manner[J].Environmental Pollution,2013,173:257-263
• [17]Cakal Arslan O,Parlak H.Embryotoxic effects of nonylphenol and octylphenol in sea urchin Arbacia lixula[J].Ecotoxicology,2007,16(6):439-444
• [18]金小伟,查金苗,许宜平,等.氯酚类化合物对青鱼和细鳞斜颌鯝幼鱼的毒性[J].环境科学学报,2010,30(6):1235-1242Jin X W,Zha J M,Xu Y P,et al.Acute and chronic toxicities of three chlorophenols to Mylopharyngodon piceus and Plagiognathops microlepis at early life stage[J].Acta Scientiae Circumstantiae,2010,30(6):1235-1242(in Chinese)
• [19]蒋琳,周珍,胡俊,等.五氯酚和八氯代二苯并二噁英复合暴露对斑马鱼胚胎发育的毒性效应[J].生态毒理学报,2008,3(4):370-376Jiang L,Zhou Z,Hu J,et al.Combined toxicity of pentachlorophenol(PCP)and octachlorodibenzo-p-dioxin(OCDD)on development of zebrafish(Danio rerio)embryos[J].Asian Journal of Ecotoxicology,2008,3(4):370-376(in Chinese)
• [20]郑新梅,丁亮,刘红玲,等.对硝基酚对大型蚤和斑马鱼胚胎的毒性[J].生态毒理学报,2010,5(5):692-697Zheng X M,Ding L,Liu H L,et al.Toxicity of p-nitrophenol to Daphnia Magna and zebrafish(Brachydanio rerio)embryo[J].Asian Journal of Ecotoxicology,2010,5(5):692-697(in Chinese)
• [21]Saili K S,Corvi M M,Weber D N,et al.Neurodevelopmental low-dose bisphenol A exposure leads to early lifestage hyperactivity and learning deficits in adult zebrafish[J].Toxicology,2012,291(1-3):83-92
• [22]Qin F,Wang L,Wang X,et al.Bisphenol A affects gene expression of gonadotropin-releasing hormones and type I GnRH receptors in brains of adult rare minnow Gobiocypris rarus[J].Comparative Biochemistry and Physiology Part C:Toxicology&Pharmacology,2013,157(2):192-202
• [23]Vosges M,Kah O,Hinfray N,et al.17α-Ethinylestradiol and nonylphenol affect the development of forebrain GnRH neurons through an estrogen receptors-dependent pathway[J].Reproductive Toxicology,2012,33(2):198-204
• [24]Wang X,Dong Q,Chen Y,et al.Bisphenol A affects axonal growth,musculature and motor behavior in developing zebrafish[J].Aquatic Toxicology,2013,142-143:104-113
• [25]黄敏毅,俞丽丽,段仁燕,等.壬基酚对黑斑蛙神经活动的影响[J].生态学杂志,2009,28(8):1510-1514Huang M Y,Yu L L,Duan R Y,et al.Effects of nonylphenol on Rana nigromaculata nerve action[J].Chinese Journal of Ecology,2009,28(8):1510-1514(in Chinese)
• [26]Pandey A K,Deshpande S B.Bisphenol A depresses compound action potential of frog sciatic nerve in vitro involving Ca(+)-dependent mechanisms[J].Neuroscience Letters,2012,517(2):128-132
• [27]胡双庆,沈根祥,赵庆节.双酚A对鲫鱼淋巴细胞和巨噬细胞的免疫毒性研究[J].上海环境科学,2007,26(2):71-76.Hu S Q,Shen G X,Zhao Q J.A study on immunotoxicity of bisphenol A to lymphocytes and macrophages of Carassius auratus following in vitro exposure[J].Shanghai Environmental Sciences,2007,26(2):71-76(in Chinese)
• [28]Shelley L K,Ross P S,Miller K M,et al.Toxicity of atrazine and nonylphenol in juvenile rainbow trout(Oncorhynchus mykiss):Effects on general health,disease susceptibility and gene expression[J].Aquatic Toxicology,2012,124-125:217-226
• [29]赵莉.壬基酚对中华绒螯蟹(Eriocheir sinensis)的免疫毒性及雌激素效应研究[D].上海:华东师范大学,2010:17-21Zhao L.Immunotoxicity and estrogenic effects of nonylphenol on Chinese mitten crab(Eriocheir sinensis)[D].Shanghai:East China Normal University,2010:17-21(in Chinese)
• [30]张静.环境激素对斑马鱼免疫相关基因表达的影响[D].济南:山东师范大学,2012:34-54Zhang J.Effects of environmental hormones on the expres-sion of immune-related genes of the zebrafish(Danio Rerio)[D].Jinan:Shandong Normal University,2012:34-54(in Chinese)
• [31]Xu H,Yang M,Qiu W,et al.The impact of endocrinedisrupting chemicals on oxidative stress and innate immune response in zebrafish embryos[J].Environmental Toxicology and Chemistry,2013,32(8):1793-1799
• [32]张海丽,边海燕,杨跃志,等.酚类污染物对菲律宾蛤仔抗氧化和解毒系统相关酶活性的影响[J].中国海洋大学学报,2012,42(3):21-26Zhang H L,Bian H Y,Yang Y Z,et al.Effects of phenolic compounds on enzyme activities of antioxidant and detoxification systems in Ruditapes philippinarum[J].Periodical of Ocean University of China,2012,42(3):21-26(in Chinese)
• [33]Wu M,Xu H,Shen Y,et al.Oxidative stress in zebrafish embryos induced by short-term exposure to bisphenol A,nonylphenol,and their mixture[J].Environmental Toxicology and Chemistry,2011,30(10):2335-2341
• [34]王辅明,朱祥伟,马永鹏,等.低浓度五氯酚暴露对稀有鮈鲫体内SOD活性、GSH和HSP70含量的影响[J].生态毒理学报,2009,4(3):415-421Wang F M,Zhu X W,Ma Y P,et al.Effects of low concentration of pentachlorophenol exposure on SOD activity,GSH and HSP70 content in Rare Minnow(Gobiocypris rarus)[J].Asian Journal of Ecotoxicology,2009,4(3):415-421(in Chinese)
• [35]宋志慧,王庆伟.三苯基锡和五氯酚胁迫斑马鱼生理生化的影响[J].生态毒理学报,2011,6(1):99-104Song Z H,Wang Q W.Effect of TPT and PCP stress on physiology and biochemistry of zebrafish[J].Asian Journal of Ecotoxicology,2011,6(1):99-104(in Chinese)
• [36]Kim B M,Rhee J S,Park G S,et al.Cu/Zn-and Mnsuperoxide dismutase(SOD)from the copepod Tigriopus japonicus:Molecular cloning and expression in response to environmental pollutants[J].Chemosphere,2011,84(10):1467-1475
• [37]Nair P M,Park S Y,Choi J.Expression of catalase and glutathione S-transferase genes in Chironomus riparius on exposure to cadmium and nonylphenol[J].Comparative Biochemistry and Physiology Part C:Toxicology&Pharmacology,2011,154(4):399-408
• [38]Kishida M,McLellan M,Miranda J A,et al.Estrogen and xenoestrogens upregulate the brain aromatase isoform(P450aromB)and perturb markers of early development in zebrafish(Danio rerio)[J].Comparative Biochemistry and Physiology Part B:Biochemistry and Molecular Biology,2001,129(2-3):261-268
• [39]Kortner T M,Vang S H,Arukwe A.Modulation of salmon ovarian steroidogenesis and growth factor responses by the xenoestrogen,4-nonylphenol[J].Chemosphere,2009,77(7):989-998
• [40]Nair P M,Choi J.Effects of cadmium chloride and nonylphenol on the expression of StAR-related lipid transfer domain containing protein(START1)gene in aquatic midge,Chironomus riparius[J].Comparative Biochemistry and Physiology Part C:Toxicology&Pharmacology,2012,155(2):369-374
• [41]Kirk C J,Bottomley L,Minican N,et al.Environmental endocrine disrupters dysregulate estrogen metabolism and Ca2+homeostasis in fish and mammals via receptor-independent mechanisms[J].Comparative Biochemistry and Physiology Part A:Molecular&Integrative Physiology,2003,135(1):1-8
• [42]Palermo F A,Cocci P,Angeletti M,et al.PCR-ELISA detection of estrogen receptorβmRNA expression and plasma vitellogenin induction in juvenile sole(Solea solea)exposed to waterborne 4-nonylphenol[J].Chemosphere,2012,86(9):919-25
• [43]李惠云,刘鹏威,魏华.双酚A对鲫雌激素受体表达和雌二醇水平的影响[J].上海水产大学学报,2008,17(6):641-646Li H Y,Liu P W,Wei H.Effects of bisphenol-A on expression of estrogen receptor and level of 17β-eatradiol in vivo of female Carassius auratus[J].Journal of Shanghai Fisheries University,2008,17(6):641-646(in Chinese)
• [44]Hatef A,Zare A,Alavi S M,et al.Modulations in androgen and estrogen mediating genes and testicular response in male goldfish exposed to bisphenol A[J].Environmental Toxicology and Chemistry/SETAC,2012,31(9):2069-2077
• [45]Seo J S,Lee Y M,Jung S O,et al.Nonylphenol modulates expression of androgen receptor and estrogen receptor genes differently in gender types of the hermaphroditic fish Rivulus marmoratus[J].Biochemical and Biophysical Research Communications,2006,346(1):213-223
• [46]Planell R,Mart nez-Guitarte J L,Morcillo G.The endocrine disruptor bisphenol A increases the expression of HSP70 and ecdysone receptor genes in the aquatic larvae of Chironomus riparius[J].Chemosphere,2008,71(10):1870-1876
• [47]Zhou J,Zhou X S,Cai Z H.The impacts of bisphenol A(BPA)abalone(Haliotis diversicolor supertexta)embryonic development[J].Chemosphere,2011,82(3):443-450
• [48]Canesi L,Betti M,Lorusso L C,et al.In vivo'effects of bisphenol A in Mytilus hemocytes:Modulation of kinasemediated signaling pathways[J].Aquatic Toxicolgy,2005,71(1):73-84
• [49]乔坤,刘媛媛,李玉华,等.双酚A斑马鱼雄性生殖毒性的表观遗传学基础[J].实验动物与比较医学,2012,32(1):30-37Qiao K,Liu Y Y,Li Y H,et al.Epigenetic influences of bisphenol A on male reproductive toxicity in zebrafish[J].Laboratory Animal and Comparative Medicine,2012,32(1):30-37(in Chinese)
• [50]胡雪雷,周静韵,段舜山.壬基酚与壬基酚聚氧乙烯醚对多刺裸腹溞的复合毒性效应[J].生态环境学报,2011,20(11):1725-1730Hu X L,Zhou J J,Duan S S.Synergistic toxic effects of nonylphenol and nonylphenol ethoxylate on Moina macrocopa[J].Ecology and Environmental Sciences,2011,20(11):1725-1730(in Chinese)
• [51]房妮,张松林,俱国鹏,等.对甲酚与2,4-二叔丁基酚对斑马鱼的联合毒性研究[J].江西农业学报,2010,22(11):122-124Fang N,Zhang S L,Ju G P,et al.Joint toxicity of p-Cresol and 2,4-di-tert-butylphenol on zebrafish(Brachydanio rerio)[J].Acta Agriculturae Jiangxi,2010,22(11):122-124(in Chinese)