全氟化合物发育神经毒性研究进展Research Progress in Developmental Neurotoxicity of Perfluorinated Compounds
韦荣国;张银凤;秦占芬;
摘要(Abstract):
全氟化合物(PFCs)在工业生产和生活中广泛应用,已成为环境中一类普遍的污染物。由于PFCs污染表现出全球性、持久性和富集性等特征,其毒性备受关注。近期研究结果显示,PFCs除对肝脏、免疫系统和生殖内分泌系统等有明显影响外,还具有发育神经毒性。在总结了近年来PFCs发育神经毒性的研究进展基础上,讨论了PFCs发育神经毒性可能的几个机制,并且分析该领域研究存在的问题,提出应该加强环境相关剂量下PFCs发育神经毒性研究,关注PFCs与其他神经毒物复合暴露的发育神经毒性,以推进对实际环境中PFCs所产生的神经损伤的认识。
关键词(KeyWords): 全氟化合物;发育神经毒性;环境相关剂量
基金项目(Foundation): “863”计划课题(2010AA065105);; 国家自然科学基金项目(21077125);; 环保公益专项(201109048)
作者(Author): 韦荣国;张银凤;秦占芬;
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DOI:
参考文献(References):
- [1]Paul A G,Jones K C,Sweetman A J.A first global pro-duction,emission,and environmental inventory for perfluorooctane sulfonate[J].Environmental Science&Technology,2009,43(2):386-392
- [2]Kannan K,Choi J W,Iseki N,et al.Concentrations of perfluorinated acids in livers of birds from Japan and Korea[J].Chemosphere,2002,49(3):225-231
- [3]Ostertag S K,Chan H M,Moisey J,et al.Historic diet-ary exposure to perfluorooctane sulfonate,perfluorinat-ed carboxylates,and fluorotelomer unsaturated carbox-ylates from the consumption of store-bought and res-taurant foods for the Canadian population[J].Journal of Agricultural and Food Chemistry,2009,57(18):8534-8544
- [4]Martin J W,Asher B J,Beesoon S,et al.PFOS or Pre-FOS?Are perfluorooctane sulfonate precursors(Pre-FOS)important determinants of human and environ-mental perfluorooctane sulfonate(PFOS)exposure?[J].Journal of Environmental Monitoring,2010,12(11):1979-2004
- [5]Renner R.The long and the short of perfluorinated re-placements[J].Environmental Science&Technology,2006,40(1):12-13
- [6]Cassone C G,Vongphachan V,Chiu S,et al.In ovo effects of perfluorohexane sulfonate and perfluorohex-anoate on pipping success,development,mRNA ex-pression,and thyroid hormone levels in chicken embry-os[J].Toxicological Sciences,2012,127(1):216-224
- [7]Wilhelm M,Bergmann S,Dieter H H.Occurrence of perfluorinated compounds(PFCs)in drinking water of North Rhine-Westphalia,Germany and new approach to assess drinking water contamination by shorter-chained C4-C7PFCs[J].International Journal of Hy-giene and Environmental Health,2010,213(3):224232
- [8]Butenhoff J L,Ehresman D J,Chang S C,et al.Gesta-tional and lactational exposure to potassium perfluo-rooctanesulfonate(K+PFOS)in rats:Developmental neurotoxicity[J].Reproductive Toxicology,2009,27(3-4):319-330
- [9]Huang H,Huang C,Wang L,et al.Toxicity,uptake ki-netics and behavior assessment in zebrafish embryos following exposure to perfluorooctane sulphonic acid(PFOS)[J].Aquatic Toxicology,2010,98(2):139-147
- [10]Wang M,Chen J,Lin K,et al.Chronic zebrafish PFOS exposure alters sex ratio and maternal related effects in F1offspring[J].Environmental Toxicology&Chemis-try,2011,30(9):2073-2080
- [11]Johansson N,Fredriksson A,Eriksson P.Neonatal ex-posure to perfluorooctane sulfonate(PFOS)and perflu-orooctanoic acid(PFOA)causes neurobehavioural de-fects in adult mice[J].Neurotoxicology,2008,29(1):160-169
- [12]Lau C,Thibodeaux J R,Hanson R G,et al.Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse.II:Postnatal evaluation[J].Toxicological Sci-ences,2003,74(2):382-392
- [13]Fuentes S,Colomina M T,Vicens P,et al.Influence of maternal restraint stress on the long-lasting effects induced by prenatal exposure to perfluorooctane sulfonate(PFOS)in mice[J].Toxicology Letters,2007,171(3):162-170
- [14]Onishchenko N,Fischer C,Wan Ibrahim W N,et al.Prenatal exposure to PFOS or PFOA alters motor func-tion in mice in a sex-related manner[J].Neurotoxicity Research,2011,19(3):452-461
- [15]Luebker D J,Case M T,York R G,et al.Two-genera-tion reproduction and cross-foster studies of perfluo-rooctanesulfonate(PFOS)in rats[J].Toxicology,2005,215(1-2):126-148
- [16]Fuentes S,Vicens P,Colomina M T,et al.Behavioral effects in adult mice exposed to perfluorooctane sulfon-ate(PFOS)[J].Toxicology,2007,242(1-3):123-129
- [17]Pinkas A,Slotkin T A,Brick-Turin Y,et al.Neurobe-havioral teratogenicity of perfluorinated alkyls in an a-vian model[J].Neurotoxicology and Teratology,2010,32(2):182-186
- [18]Slotkin T A,MacKillop E A,Melnick R L,et al.De-velopmental neurotoxicity of perfluorinated chemicals modeled in vitro[J].Environmental Health Perspec-tives,2008,116(6):716-722
- [19]Liao C Y,Li X Y,Wu B,et al.Acute enhancement of synaptic transmission and chronic inhibition of synap-togenesis induced by perfluorooctane sulfonate through mediation of voltage-dependent calcium channel[J].Environmental Science&Technology,2008,42(14):5335-5341
- [20]Peden-Adams M M,Stuckey J E,Gaworecki K M,et al.De-velopmental toxicity in white leghorn chickens following in ovo exposure to perfluorooctane sulfonate(PFOS)[J].Re-productive Toxicology,2009,27(3-4):307-318
- [21]Zhang L,Li Y Y,Zeng H C,et al.Perfluorooctane sulfonate induces apoptosis in N9microglial cell line[J].International Journal of Toxicology,2011,30(2):207-215
- [22]Johansson N,Eriksson P,Viberg H.Neonatal exposure to PFOS and PFOA in mice results in changes in pro-teins which are important for neuronal growth and syn-aptogenesis in the developing brain[J].Toxicological Sciences,2009,108(2):412-418
- [23]Zeng H C,Zhang L,Li Y Y,et al.Inflammation-like glial response in rat brain induced by prenatal PFOS ex-posure[J].Neurotoxicology,2011,32(1):130-139
- [24]Zeng H C,Li Y Y,Zhang L,et al.Prenatal exposure to perfluorooctanesulfonate in rat resulted in long-lasting changes of expression of synapsins and synaptophysin[J].Synapse,2011,65(3):225-233
- [25]Li Y,Jin Y H.Effects of perfluorooctane sulfonylsulfonate on glutamate concentration of central nervous system in rats[J].Journal of Health Toxicology,2004,18(4):232-234
- [26]王柯,金一和,于棋麟,等.全氟辛烷磺酸对小鼠大脑谷氨酸含量和蛋白激酶活性的影响[J].中华预防医学杂志,2007,41(6):466-470Wang K,Jin Y H,Yu Q L,et al.Effects of perfluo-rooctane sulfonate on Glu,PKC and PKA activities in mouse brain[J].Zhonghua Yu Fang Yi Xue Za Zhi,2007,41(6):466-470.
- [27]Liu C,Yu K,Shi X,et al.Induction of oxidative stress and apoptosis by PFOS and PFOA in primary cultured hepatocytes of freshwater tilapia(Oreochromis nilotic-us)[J].Aquatic Toxicology,2007,82(2):135-143
- [28]Hu X Z,Hu D C.Effects of perfluorooctanoate and perfluorooctane sulfonate exposure on hepatoma HepG2cells[J].Archives of Toxicology,2009,83(9):851-861
- [29]Lee H G,Lee Y J,Yang J H.Perfluorooctane sulfonate induces apoptosis of cerebellar granule cells via a ROS-dependent protein kinase C signaling pathway[J].Neu-rotoxicology,2012,33(3):314-320
- [30]Shi X,Du Y,Lam P K,et al.Developmental toxicity and alteration of gene expression in zebrafish embryos exposed to PFOS[J].Toxicology and Applied Pharma-cology,2008,230(1):23-32
- [31]Shi X,Yeung L W,Lam P K,et al.Protein profiles in zebrafish(Danio rerio)embryos exposed to perfluo-rooctane sulfonate[J].Toxicological Sciences,2009,110(2):334-340
- [32]Yang H,Dong H S,Lin Y L,et al.Research progress of protein kinase C in neuroprotection[J].Medical Reca-pitulate,2009,15(18):2736-2738
- [33]刘冰,于麒麟,金一和,等.全氟辛烷磺酸对大鼠海马神经细胞内钙离子浓度的影响[J].毒理学杂志,2005,19(S1):225
- [34]Liu X,Liu W,Jin Y,et al.Effects of subchronic perflu-orooctane sulfonate exposure of rats on calcium-de-pendent signaling molecules in the brain tissue[J].Ar-chives of Toxicology,2010,84(6):471-479
- [35]Liao C Y,Cui L,Zhou Q F,et al.Effects of perfluo-rooctane sulfonate on ion channels and glutamate-acti-vated current in cultured rat hippocampal neurons[J].Environmental Toxicology and Pharmacology,2009,27(3):338-344
- [36]Liu X,Jin Y,Liu W,et al.Possible mechanism of per-fluorooctane sulfonate and perfluorooctanoate on the release of calcium ion from calcium stores in primary cultures of rat hippocampal neurons[J].Toxicology in Vitro,2011,25(7):1294-1301
- [37]Haddow J E,Palomaki G E,Allan W C,et al.Maternal thyroid deficiency during pregnancy and subsequent neu-ropsychological development of the child[J].New Eng-land Journal of Medicine,1999,341(8):549-555
- [38]Zoeller R T,Crofton K M.Mode of action:develop-mental thyroid hormone insufficiency--neurological ab-normalities resulting from exposure to propylthiouracil[J].Critical Reviews in Toxicology,2005,35(8-9):771-781
- [39]Austin M E,Kasturi B S,Barber M,et al.Neuroendo-crine effects of perfluorooctane sulfonate in rats[J].Environmental Health Perspectives,2003,111(12):1485-1489
- [40]Chang S C,Thibodeaux J R,Eastvold M L,et al.Thy-roid hormone status and pituitary function in adult rats given oral doses of perfluorooctanesulfonate(PFOS)[J].Toxicology,2008,243(3):330-339
- [41]Wang F,Liu W,Jin Y,et al.Interaction of PFOS and BDE-47co-exposure on thyroid hormone levels and TH-related gene and protein expression in developing rat brains[J].Toxicological Sciences,2011,121(2):279-291
- [42]Vongphachan V,Cassone C G,Wu D,et al.Effects of perfluoroalkyl compounds on mRNA expression levels of thyroid hormone-responsive genes in primary cul-tures of avian neuronal cells[J].Toxicological Sciences,2011,120(2):392-402
- [43]Myers J P,Zoeller R T,vom Saal F S.A clash of old and new scientific concepts in toxicity,with important implications for public health[J].Environmental Health Perspectives,2009,117(11):1652-1655
- [44]Andrade A J,Grande S W,Talsness C E,et al.A dose-response study following in utero and lactational expo-sure to di-(2-ethylhexyl)-phthalate(DEHP):Non-mon-otonic dose-response and low dose effects on rat brain aromatase activity[J].Toxicology,2006,227(3):185-192
- [45]Narita S,Goldblum R M,Watson C S,et al.Environmental estrogens induce mast cell degranulation and enhance IgE-mediated release of allergic mediators[J].Environmental Health Perspectives,2007,115(1):48-52
- [46]Lau C,Thibodeaux J R,Hanson R G,et al.Effects of perfluorooctanoic acid exposure during pregnancy in the mouse[J].Toxicological Sciences,2006,90(2):510-518
- [47]Jacquet N,Maire M A,Landkocz Y,et al.Carcinogenic potency of perfluorooctane sulfonate(PFOS)on Syrian hamster embryo(SHE)cells[J].Archives of Toxicolo-gy,2012,86(2):305-314
- [48]Dorts J,Kestemont P,Marchand P A,et al.Ecotoxi-coproteomics in gills of the sentinel fish species,Cottus gobio,exposed to perfluorooctane sulfonate(PFOS)[J].Aquatic Toxicology,2011,103(1-2):1-8
- [49]Birnbaum L S.Applying research to public health ques-tions:timing and the environmentally relevant dose[J].Environmental Health Perspectives,2009,117(11):1652-1655
- [50]Newsted J L,Beach S A,Gallagher S P,et al.Acute and chronic effects of perfluorobutane sulfonate(PFBS)on the mallard and northern bobwhite quail[J].Archives of Environmental Contamination and Toxicology,2008,54(3):535-545
- [51]Wolf C J,Takacs M L,Schmid J E,et al.Activation of mouse and human peroxisome proliferator-activated re-ceptor alpha by perfluoroalkyl acids of different func-tional groups and chain lengths[J].Toxicological Sci-ences,2008,106(1):162-171
- [52]Foreman J E,Chang S C,Ehresman D J,et al.Differ-ential hepatic effects of perfluorobutyrate mediated by mouse and human PPAR-alpha[J].Toxicological Sci-ences,2009,110(1):204-211
- [53]Calafat A M,Wong L Y,Kuklenyik Z,et al.Polyflu-oroalkyl chemicals in the U.S.population:Data from the National Health and Nutrition Examination Survey(NHANES)2003-2004and comparisons with NHANES1999-2000[J].Environmental Health Perspectives,2007,115(11):1596-1602
- [54]Naile J E,Wiseman S,Bachtold K,et al.Transcription-al effects of perfluorinated compounds in rat hepatoma cells[J].Chemosphere,2012,86(3):270-277
- [55]Scialli A R,Iannucci A,Turim J.Combining perfluoro-alkane acid exposure levels for risk assessment[J].Reg-ulatory Toxicology and Pharmacology,2007,49(3):195-202
- [56]Fromme H,Albrecht M,Angerer J,et al.Integrated exposure assessment survey(INES)exposure to persistent and bioaccumulative chemicals in Bavaria,Germany[J].International Journal of Hygiene and Environmental Health,2007,210(3-4):345-349
- [57]Wei Y,Shi X,Zhang H,et al.Combined effects of polyfluorinated and perfluorinated compounds on pri-mary cultured hepatocytes from rare minnow(Gobio-cypris rarus)using toxicogenomic analysis[J].Aquatic Toxicology,2009,95(1):27-36
- [58]Dorne J L C M,Bordajandi L R,Amzal B,et al.Com-bining analytical techniques,exposure assessment and biological effects for risk assessment of chemicals in food[J].Trends in Analytical Chemistry,2009,28(6):695-707
- [59]Nakayama K,Iwata H,Tao L,et al.Potential effects of perfluorinated compounds in common cormorants from Lake Biwa,Japan:An implication from the he-patic gene expression profiles by microarray[J].Envi-ronmental Toxicology&Chemistry,2008,27(11):2378-2386
- [60]Fei C,Olsen J.Prenatal exposure to perfluorinated chemicals and behavioral or coordination problems at age7years[J].Environmental Health Perspectives,2011,119(4):573-578
- [61]Wang F,Liu W,Jin Y,et al.Transcriptional effects of prenatal and neonatal exposure to PFOS in developing rat brain[J].Environmental Science&Technology,2010,44(5):1847-1853
- [62]Kozul C D,Ely K H,Enelow R I,et al.Low-dose arse-nic compromises the immune response to influenza an infection in vivo[J].Environmental Health Perspec-tives,2009,117(9):1441-1447
- [63]Bardullas U,Limon-Pacheco J H,Giordano M,et al.Chronic low-level arsenic exposure causes gender-spe-cific alterations in locomotor activity,dopaminergic systems,and thioredoxin expression in mice[J].Toxi-cology and Applied Pharmacology,2009,239(2):169-177