生态毒理学报

2016, v.11(02) 134-143

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MiR-125a-5p is Upregulated in Plasma of Residents from An Electronic Waste Recycling Site
MiR-125a-5p is Upregulated in Plasma of Residents from An Electronic Waste Recycling Site

Li Ran;Qiu Xinghua;Yang Qiaoyun;Li Keqiu;Li Guang;

摘要(Abstract):

The mechanism of health effects caused by organohalogen pollutants, e.g., toxins from electronic waste(e-waste), is poorly understood. We supposed that micro RNAs(mi RNAs), an important post-transcriptional regulator, could play a role in this process. In this study, fasting peripheral blood samples were collected from residents living at an e-waste site in northern China and a nearby reference population. Concentrations of e-waste related organohalogen pollutants in plasma from the exposure group were higher than the corresponding measurement in the reference group. Correspondingly, sixty mi RNAs in plasma showed > 2-fold change between the two groups in microarray analysis. Among them, mi R-125a-5p was confirmed to be upregulated by q RT-PCR and its validated targets were enriched in responses to xenobiotics and cancer related pathways. Furthermore, significant positive correlations were found between levels of mi R-125a-5p in plasma and reactive oxygen species(ROS) in polymorphonuclear neutrophil leukocytes(P < 0.05). These evidences suggested oxidative stress might be an intermediate between e-waste related POPs exposure and alteration of plasma mi RNA.

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基金项目(Foundation): National Natural Science Foundation of China(21322705,41121004,21190051,and 21177091)

作者(Author): Li Ran;Qiu Xinghua;Yang Qiaoyun;Li Keqiu;Li Guang;

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