陆杰;张婷;唐萌;

• 1:东南大学公共卫生学院&苏州纳米科技协同创新中心
• 2:环境医学工程教育部重点实验室
• 3:江苏省生物材料与器件重点实验室

摘要(Abstract)：

随着纳米技术和纳米医学的飞速发展,越来越多的纳米材料应用于生物医学领域。量子点(QDs)作为一种新型的荧光材料在工业和医学领域有着广阔的应用前景,而碲化镉量子点(cadmium telluride quantum dots,CdTeQDs)是目前常用的一种QDs,其生物安全性引起了极大的关注。体内外的研究表明CdTeQDs可以对生物体造成损害。CdTeQDs的细胞毒性主要表现为细胞活力和生存率降低,细胞正常形态被破坏,基因突变,染色体畸变以及细胞凋亡的出现。而毒性机制的研究集中于活性氧(ROS)水平的升高,线粒体形态和功能的破坏,DNA受损和自噬作用等方面。笔者综述了CdTeQDs对体外细胞造成的毒性作用及其机制,旨在为CdTeQDs的生物安全性研究和更好的应用提供有价值的参考。

关键词(KeyWords)： 碲化镉量子点;细胞毒性;毒作用机制;影响因素

Abstract:

Keywords:

基金项目(Foundation): 国家重大科学研究计划项目资助(NO.2011CB933404);; 国家自然科学基金项目(81302461,81473003,81502783,81573186,31671034,81673218)

作者(Author): 陆杰;张婷;唐萌;

Email:

DOI:

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