中心复合设计射线法考察离子液体C_(16)H_(31)ClN_2与乐果的毒性相互作用Study on the Toxicity Interaction between Dimethoate and C_(16)H_(31)ClN_2 by Central Composite Design with the Fixed Concentration Ratio Ray
张晶;王金承;刘树深;葛会林;刘海玲;
摘要(Abstract)：
离子液体(ILs)是一种用于替代传统易挥发有机溶剂的新型"绿色"溶剂.由于不挥发、不会对大气产生污染而得到广泛应用.但是某些ILs易溶于水,其自身毒性能够对生态环境造成潜在影响,这已引起诸多学者对ILs毒性的研究兴趣.然而ILs与其它污染物的毒性相互作用目前研究很少.论文选取咪唑类离子液体C16H31ClN(2DMI)与有机磷杀虫剂乐果(DIM)作为目标化合物,以青海弧菌Q67为检测生物,采用微板毒性分析法测定了目标化合物及其混合物的毒性.为全面考察不同浓度范围DMI与DIM的毒性相互作用,将中心复合设计与固定浓度比射线法有机结合起来构建5个不同浓度比的混合物射线,通过浓度加和与独立作用模型对混合物射线进行比较评估.结果表明在DMI浓度较大且DIM浓度较低时,DMI与DIM之间存在明显拮抗作用,而在其它浓度范围内两者之间为加和作用.
关键词(KeyWords)： C16H31ClN2;乐果;毒性相互作用;微板毒性分析;中心复合设计射线法
基金项目(Foundation): 国家自然科学基金项目(No.20777056);; 国家863计划专题课题(No.2007AA06Z417)
作者(Author): 张晶;王金承;刘树深;葛会林;刘海玲;
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