六价铬化合物的肝脏毒性及其作用机制研究进展Research Overview on Hepatotoxicity and the Related Mechanism of Hexavalent Chromium Compounds
王而今;曾明;
摘要(Abstract):
六价铬化合物普遍存在于环境中,并被广泛应用于多种工业生产中,由此引发的铬污染及健康问题已经引起了人们的重视。作为体内代谢及解毒的重要场所,肝脏是Cr(Ⅵ)毒性作用的靶器官之一。本文对Cr(Ⅵ)化合物在环境中的污染来源与污染状况、机体内吸收、分布与代谢及对肝脏的毒性损害及其作用机制的研究现状加以综述。
关键词(KeyWords): 六价铬化合物;肝脏毒性;氧化损伤;细胞凋亡;线粒体损伤;钙稳态失衡
基金项目(Foundation): 国家自然科学基金(81673225,81773478);; 中南大学研究生自主探索创新项目(2018zzts846)
作者(Author): 王而今;曾明;
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