化学品生态毒性测试鱼类模式生物的应用与展望Application and Outlook of Various Fish Models Used in Chemical Ecotoxicity Test
沈敏;Katherine Coady;董晶;John Davis;胡璟;柴运宙;高仁君;
摘要(Abstract):
水生生物毒性测试广泛应用于评估化学品的水生态环境安全,而鱼类生态毒性数据为水生生态风险评估与风险管理提供基础。本文总结了现有的鱼类水生毒性测试标准及常用的物种。阐述了常用水生鱼类模式生物,如斑马鱼Danio rerio、青鳉鱼Oryzias latipes、黑头软口鲦Pimephales promelas等作为模式鱼类的特征及在生态毒性测试中的应用。环保部7号令推荐稀有鮈鲫Gobiocypris rarus作为中国本土生物在水生毒性测试中使用。目前公开发表的利用稀有鮈鲫的水生毒性研究多集中在急性毒性方面,对其他类型的研究如法规毒理相关的长期慢性毒性有待开展。
关键词(KeyWords): 模式鱼类;稀有鮈鲫;斑马鱼;青鳉鱼;黑头软口鲦;生态毒理测试
基金项目(Foundation):
作者(Author): 沈敏;Katherine Coady;董晶;John Davis;胡璟;柴运宙;高仁君;
Email:
DOI:
参考文献(References):
- [1]Fields S,Johnson M.Whither model organism research?[J].Science,2005,307(5717):1885-1886
- [2]Di Giulio R T,Hinton D E.The Toxicology of Fishes[M].CRC Press,2008:3-66
- [3]环境保护部化学品登记中心.化学品测试方法生物系统效应卷,203鱼类急性毒性试验[S].北京:环境保护部化学品登记中心,2013MEP SCC.The guidelines for the testing of chemicals—Effects on biotic systems,203 Fish acute toxicity test[S].Beijing:MEP SCC,2013(in Chinese)
- [4]中华人民共和国质量监督检验检疫总局,中国国家标准化管理委员会.GB/T 27861—2011.化学品鱼类急性毒性试验[S].北京:中华人民共和国质量监督检验检疫总局,中国国家标准化管理委员会,2011General Administration of Quality Supervision,Inspection and Quarantine of PRC,Standardization Administration of PRC.GB/T 27861-2011,Chemicals-Fish acute toxicity test[S].Being:General Administration of Quality Supervision,Inspection and Quarantine of PRC,Standardization Administration of PRC,2011(in Chinese)
- [5]OECD.Guidelines for Testing of Chemicals,203:Fish,Acute Toxicity Test[S].Paris:OECD,1992
- [6]ISO.ISO 7346-1,-2,-3,Water quality—Determination of the acute lethal toxicity of substances to a freshwater fish[Brachydanio rerio Hamilton-Buchanan(Teleostei,Cyprindidae)],part 1 static method;part 2 semi-static;part 3flow-through method[S].Geneva:ISO,1996
- [7]United States Environmental Protection Agency.Ecological Effects Test Guidelines,OPPTS 850.1075,Fish acute toxicity test,freshwater and marine[S].Washington DC:US EPA,1996
- [8]United States Environmental Protection Agency.Ecological Effects Test Guidelines,OPPTS 850.1085,Fish acute toxicity mitigated by humic acid[S].Washington DC:US EPA,1996
- [9]OECD.Guidelines for Testing of Chemicals,236:Fish Embryo Acute Toxicity(FET)Test[S].Paris:OECD,2013
- [10]环境保护部化学品登记中心.化学品测试方法生物系统效应卷,204鱼类14天延长毒性试验[S].北京:环境保护部化学品登记中心,2013MEP SCC.The guidelines for the testing of chemicals—Effects on biotic systems,204 Fish prolonged toxicity:14-day study test[S].Beijing:MEP SCC,2013(in Chinese)
- [11]中华人民共和国质量监督检验检疫总局,中国国家标准化管理委员会.GB/T 21808—2008化学品鱼类延长毒性14天试验[S].北京:中华人民共和国质量监督检验检疫总局,中国国家标准化管理委员会,2008General Administration of Quality Supervision,Inspection and Quarantine of PRC,Standardization Administration of PRC.GB/T 21808-2008 Chemicals-Fish prolonged toxicity:14-day study test[S].Beijing:General Administration of Quality Supervision,Inspection and Quarantine of PRC,Standardization Administration of PRC,2008(in Chinese)
- [12]OECD.Guidelines for Testing of Chemicals,204:Fish,Prolonged Toxicity Test:14-Day Study[S].Paris:OECD,1984
- [13]ISO.ISO 10229.Water quality—Determination of the prolonged toxicity of substances to freshwater fish—Method for evaluating the effects of substances on the growth rate of rainbow trout[Oncorhynchus mykiss Walbaum(Teleostei,Salmonidae)][S].Geneva:ISO,1994
- [14]环境保护部化学品登记中心.化学品测试方法生物系统效应卷,210鱼类早期生命阶段毒性试验[S].北京:环境保护部化学品登记中心,2013MEP SCC.The guidelines for the testing of chemicals—Effects on biotic systems,210 Fish early-life stage toxicity test[S].Beijing:MEP SCC,2013(in Chinese)
- [15]中华人民共和国质量监督检验检疫总局,中国国家标准化管理委员会.GB/T 21854—2008化学品鱼类早期生命阶段试验[S].北京:中华人民共和国质量监督检验检疫总局,中国国家标准化管理委员会,2008General Administration of Quality Supervision,Inspection and Quarantine of PRC,Standardization Administration of PRC.GB/T 21854-2008 Chemicals-Fish early-life stage toxicity test[S].Beijing:General Administration of Quality Supervision,Inspection and Quarantine of PRC,Standardization Administration of PRC,2008(in Chinese)
- [16]OECD.Guidelines for Testing of Chemicals,210:Fish,Early-Life Stage Toxicity Test[S].Paris:OECD,1992
- [17]United States Environmental Protection Agency.Ecological Effects Test Guidelines,OPPTS 850.1400,Fish earlylife stage toxicity test[S].Washington DC:US EPA,1996
- [18]环境保护部化学品登记中心.化学品测试方法生物系统效应卷,212鱼类胚胎-卵黄囊吸收阶段的短期毒性试验[S].北京:环境保护部化学品登记中心,2013MEP SCC.The guidelines for the testing of chemicals—Effects on biotic systems,212 Fish short term toxicity test on embryo and sac-fry stages[S].Beijing:MEP SCC,2013(in Chinese)
- [19]中华人民共和国质量监督检验检疫总局,中国国家标准化管理委员会.GB/T 21807—2008,化学品鱼类胚胎和卵黄囊仔鱼阶段的短期毒性试验[S].北京:中华人民共和国质量监督检验检疫总局,中国国家标准化管理委员会,2008General Administration of Quality Supervision,Inspection and Quarantine of PRC,Standardization Administration of PRC.GB/T 21807-2008 Chemicals-Fish short term toxicity test on embryo and sac-fry[S].Beijing:General Administration of Quality Supervision,Inspection and Quarantine of PRC,Standardization Administration of PRC,2008(in Chinese)
- [20]OECD.Guidelines for Testing of Chemicals,212:Fish,Short-term Toxicity Test on Embryo and Sac-Fry Stages[S].Paris:OECD,1998
- [21]ISO.ISO 12890.Water quality-Determination of toxicity to embryos and larvae of freshwater fish--semi-static method[S].Geneva:ISO,1999
- [22]环境保护部化学品登记中心.化学品测试方法生物系统效应卷,215鱼类幼体生长试验[S].北京:环境保护部化学品登记中心,2013MEP SCC.The guidelines for the testing of chemicals—Effects on biotic systems,215 Fish juvenile growth test[S].Beijing:MEP SCC,2013(in Chinese)
- [23]中华人民共和国质量监督检验检疫总局,中国国家标准化管理委员会.GB/T 21806—2008鱼类幼体生长试验[S].北京:中华人民共和国质量监督检验检疫总局,中国国家标准化管理委员会,2008General Administration of Quality Supervision,Inspection and Quarantine of PRC,Standardization Administration of PRC.GB/T 21806-2008 Chemicals-Fish juvenile growth test[S].Beijing:General Administration of Quality Supervision,Inspection and Quarantine of PRC,Standardization Administration of PRC,2008(in Chinese)
- [24]OECD.Guidelines for Testing of Chemicals,215:Fish,Juvenile Growth Test[S].Paris:OECD,2000
- [25]United States Environmental Protection Agency.Ecological Effects Test Guidelines,OPPTS 850.1500,Fish life cycle toxicity[S].Washington DC:US EPA,1996
- [26]OECD.Guidelines for Testing of Chemicals,229:Fish Short Term Reproduction Assay[S].Paris:OECD,2012
- [27]OECD.Guidelines for Testing of Chemicals,230:21-day Fish Assay:A Short-Term Screening for Oestrogenic and Androgenic Activity,and Aromatase Inhibition[S].Paris:OECD,2009
- [28]OECD.Guidelines for Testing of Chemicals,234:Fish Sexual Development Test[S].Paris:OECD,2011
- [29]Hill A J,Teraoka H,Heideman W,et al.Zebrafish as a model vertebrate for investigating chemical toxicity[J].Toxicological Sciences,2005,86:6-19
- [30]Sipes N S,Padilla S,Knudsen T B.Zebrafish—As an integrative model for twenty-first century toxicity testing[J].Birth Defects Research(Part C),2011,93:256-257
- [31]Chakraborty C,Hsu C H,Wen Z H,et al.Zebrafish:A complete animal model for in vivo drug discovery and development[J].Current Drug Metabolism,2009,10:116-124
- [32]刘在平,张松林.斑马鱼在环境检测领域中的应用[J].环境监测与预警,2011,3(1):17-20Liu Z P,Zhang S L.Application of zebrafish in the field of environmental detection[J].Environmental Monitoring and Forewarning,2011,3(1):17-20(in Chinese)
- [33]Wittbrodt J,Shima A,Schartl M.Medaka—A model organism from the far east[J].Nature Reviews Genetics,2002,3:53-64
- [34]Shima A,Mitani H.Medaka as a research organism:Past,present and future[J].Mechanisms of Development,2004,121:599-604
- [35]Padilla S,Cowden J,Hinton D E,et al.Use of medaka in toxicity testing[J].Current Protocols in Toxicology,2009,DOI:10.1002/0471140856.tx0110s39
- [36]Kirchmaier S,Naruse K,Wittbrodt J.The genomic and genetic toolbox of the teleost medaka(Oryzias latipes)[J].Genetics,2015,199(4):905-918
- [37]Ankley G T,Villeneuve D L.The fathead minnow in aquatic toxicology:Past,present and future[J].Aquatic Toxicology,2006,78:91-102
- [38]Katsiadaki I,Sanders M,Sebire M,et al.Three-spined stickleback:An emerging model in environmental endocrine disruption[J].Environmental Sciences,2007,14:263-283
- [39]环境保护部.环境保护部令部令第7号.新化学物质环境管理办法[S].北京:环境保护部,2010MEP.MEP Order 7,Measures for environmental management of new chemical substances[S].Beijing:MEP,2010(in Chinese)
- [40]杨亚洲,蔡磊明,孟智启,等.毒死蜱对稀有鮈鲫不同生命阶段的毒性效应[J].农药学学报,2014,16(1):78-83Yang Y Z,Cai L M,Meng Z Q,et al.Toxicity effects of chlorpyrifos to different life stages of Chinese rare min-now(Gobiocypris rarus)[J].Chinese Journal of Pesticide Science,2014,16(1):78-83(in Chinese)
- [41]Zhu B,Gong Y X,Liu L,et al.Toxic effects of triazophos on rare minnow(Gobiocypris rarus)embryos and larvae[J].Chemosphere,2014,108:46-54
- [42]Li Z H,Chen L,Wu Y H,et al.Effects of waterborne cadmium on thyroid hormone levels and related gene expression in Chinese rare minnow larvae[J].Comparative Biochemistry and Physiology Part C:Toxicology&Pharmacology,2014,161:53-57
- [43]吴本丽,曹岩,罗思,等.封闭群稀有鮈鲫对几种常见化学品的敏感性[J].中国环境科学,2014,34(4):1059-1066Wu B L,Cao Y,Luo S,et al.Sensitivity of rare minnow(Gobiocypris rarus,IHB)to several common chemicals[J].China Environmental Science,2014,34(4):1059-1066(in Chinese)
- [44]林琎,王开运,许辉,等.5种新型杀菌剂对4种鱼的急性毒性及安全性评价[J].世界农药,2014,3(2):34-38Lin J,Wang K Y,Xu H,et al.Acute toxicity and safety evaluation of five new fungicides to four kinds of fishes[J].World Pesticides,2014,3(2):34-38(in Chinese)
- [45]张京佶,殷浩文,赵华清.稀有鮈鲫对重铬酸钾和3,4-二氯苯胺急性毒性研究[J].中国实验动物学报,2014,22(2):57-61Zhang J J,Yin H W,Zhao H Q.Acute toxicity of potassium bichromate and 3,4-dichloroaniline in Chinese rare minnow(Gobiocypris rarus)[J].Acta Laboratorium Animals Scientia Sinica,2014,22(2):57-61(in Chinese)
- [46]ECHA.Information on chemicals[DB].[2016-11-26].http://www.echa.europa.eu/web/guest/information-on-chemicals
- [47]Zhu L F,Li W,Zha J M,et al.Dicamba affects sex steroid hormone level and m RNA expression of related genes in adult rare minnow(Gobiocypris rarus)at environmental relevant concentrations[J].Environmental Toxicology,2015,30(6):693-703
- [48]Chen R,Liu C,Yuan L L,et al.2,4-Dichloro-6-nitrophenol,a photonitration product of 2,4-dichlorophenol,caused anti-androgenic potency in Chinese rare minnows(Gobiocypris rarus)[J].Environmental Pollution,2016,216:591-598