3种氯酚类化合物对河蚬的毒性和氧化应激Toxicity and Oxidative Stress of Three Chlorophenols to Freshwater Clam Corbicula fluminea
金小伟;查金苗;许宜平;王子健;
摘要(Abstract)：
以河蚬(Corbicula fluminea)为试验生物,研究了2,4-DCP、2,4,6-TCP和PCP的急性毒性和21d慢性毒性,并在同一条件下测试了这3种氯酚类化合物对河蚬软体组织抗氧化系统的影响.结果显示:2,4-DCP、2,4,6-TCP和PCP对河蚬96hLC50值分别为19.25(17.58～21.20)、41.98(35.48～58.24)和0.23(0.18～0.27)mg·L-1;以致死作为观察指标,其21d无观察效应浓度(NOEC)和最低观察效应浓度(LOEC)值分别为1.00、2.00、0.06mg·L-1和2.00、4.00、0.08mg·L-1.3种氯酚类化合物对河蚬软体组织抗氧化系统几种酶的活性均表现出了不同程度的影响,其中对SOD和GSH-Px的影响最为明显.2,4,6-TCP和PCP对SOD均表现为抑制作用,对GSH-Px表现为先诱导后抑制;2,4-DCP对SOD和GSH-Px表现为明显的诱导作用;3种氯酚类化合物对CAT均表现为明显的诱导作用;对GST活性也有一定影响,但与对照组相比变化范围不大(62.95%～137.04%).3种氯酚类化合物暴露后生物体抗氧化酶有不同的响应,表明不同氯酚类化合物所导致的氧化损伤及其应激机制不同.
关键词(KeyWords)： 氯酚类化合物;河蚬;毒性;抗氧化酶活性
基金项目(Foundation): 环保公益性行业科研专项(No.200709034);; 国家自然科学基金(No.40703025);; 国家“863”计划资助项目(No.2007AA06A405);; 环境模拟与污染控制国家重点联合实验室导向课题(No.S133)
作者(Author): 金小伟;查金苗;许宜平;王子健;
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DOI:
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