牛玥;朱敏;刘芃岩;秦占芬;

• 1:中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室
• 2:河北大学化学与环境科学学院
• 3:中国科学院大学

摘要(Abstract)：

双酚F(bisphenol F, BPF)和双酚AF(bisphenol AF, BPAF)作为双酚A(bisphenol A, BPA)的替代品已被投入生产和使用,然而目前有关BPA替代品毒性的数据还很缺乏。本文从急性毒性和应激响应2个方面比较了BPF、BPAF与BPA对非洲爪蛙蝌蚪的毒性。结果表明,48 h的半致死浓度(LC_(50))顺序为BPF(11.01 mg·L~(-1))>BPA(7.54 mg·L~(-1))>BPAF(2.87 mg·L~(-1));对氧化应激水平的影响BPAF强于BPA,BPF与BPA相近;BPA和BPAF对热休克蛋白基因表达水平有影响,BPF没有影响。本研究提示,BPAF作为BPA的替代品,其毒性强于BPA,而BPF与BPA类似。

关键词(KeyWords)： 双酚A;双酚F;双酚AF;非洲爪蛙;急性毒性;氧化应激;热休克蛋白

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划资助项目(2017YFF0211203);; 国家自然科学基金面上项目(21876196)

作者(Author): 牛玥;朱敏;刘芃岩;秦占芬;

Email:

DOI:

参考文献(References)：

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