双酚A替代品与双酚A对非洲爪蛙急性毒性及其应激响应的比较Comparison on Acute Toxicity and Stress Induction of Bisphenol A with Its Substitutes to Xenopus laevis
牛玥;朱敏;刘芃岩;秦占芬;
摘要(Abstract):
双酚F(bisphenol F, BPF)和双酚AF(bisphenol AF, BPAF)作为双酚A(bisphenol A, BPA)的替代品已被投入生产和使用,然而目前有关BPA替代品毒性的数据还很缺乏。本文从急性毒性和应激响应2个方面比较了BPF、BPAF与BPA对非洲爪蛙蝌蚪的毒性。结果表明,48 h的半致死浓度(LC_(50))顺序为BPF(11.01 mg·L~(-1))>BPA(7.54 mg·L~(-1))>BPAF(2.87 mg·L~(-1));对氧化应激水平的影响BPAF强于BPA,BPF与BPA相近;BPA和BPAF对热休克蛋白基因表达水平有影响,BPF没有影响。本研究提示,BPAF作为BPA的替代品,其毒性强于BPA,而BPF与BPA类似。
关键词(KeyWords): 双酚A;双酚F;双酚AF;非洲爪蛙;急性毒性;氧化应激;热休克蛋白
基金项目(Foundation): 国家重点研发计划资助项目(2017YFF0211203);; 国家自然科学基金面上项目(21876196)
作者(Author): 牛玥;朱敏;刘芃岩;秦占芬;
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