洪喻;郝立翀;陈足音;

• 1:北京林业大学环境科学与工程学院

摘要(Abstract)：

随着科技的发展,监测手段不断进步,新兴污染物普遍存在于环境中的问题及其可能带来的危害近年来才开始受到重视和研究。微藻作为初级生产者,对维持生态系统的稳定和平衡起到了至关重要的作用。本文综述了包括全氟化合物、多环芳烃、药品及个人护理品、纳米材料、微塑料和稀土元素在内的新兴污染物对微藻毒性作用及机制的研究进展。重点针对微藻的种间关系、生长和形态、对污染物的吸收和代谢、氧化应激反应、光合作用及基因表达等方面进行了总结,分析了新兴污染物作用下微藻的响应规律,归纳了新型污染物作用于微藻的毒性影响与可能机制。最后思考了其中可能存在的问题,提出了几点建议和展望。

关键词(KeyWords)： 新兴污染物;微藻;毒性作用;毒性机制

Abstract:

Keywords:

基金项目(Foundation): 北京林业大学中央高校基本科研业务费专项资金自由探索研究项目(2017ZY43);; 国家自然科学基金面上项目(51571034);; 国家大学生科研创新计划项目(201771)

作者(Author): 洪喻;郝立翀;陈足音;

Email:

DOI:

参考文献(References)：

• [1] Richardson S D. Environmental mass spectrometry:Emerging contaminants and current issues[J]. Analytical Chemistry,2002,74(12):2719-2742
• [2] Petrovic'M,Gonzalez S,BarcelóD. Analysis and removal of emerging contaminants in wastewater and drinking water[J]. Trends in Analytical Chemistry,2003,22(10):18-26
• [3]吕小明．典型新兴环境污染物的研究进展[J]．中国环境监测，2012,28(4):118-123Lv X M. Research progress of endocrine disrupting chemicals(EDCs)and pharmaceuticals and personal care products(PPCPs)[J]. Environmental Monitoring in China,2012,28(4):118-123(in Chinese)
• [4]杨红莲，袭著革，闫峻，等．新型污染物及其生态和环境健康效应[J]．生态毒理学报，2009,4(1):28-34Yang H L,Xi Z G,Yan J,et al. Ecological and environmental health effects of emerging contaminant of concern[J]. Asian Journal of Ecotoxicology,2009,4(1):28-34(in Chinese)
• [5] Richardson S D,Ternes T A. Water analysis:Emerging contaminants and current issues[J]. Analytical Chemistry,2018,90(1):398-428
• [6] Sharma B M,Becanova J,Scheringer M,et al. Health and ecological risk assessment of emerging contaminants(pharmaceuticals,personal care products,and artificial sweeteners)in surface and groundwater(drinking water)in the Ganges River Basin,India[J]. Science of the Total Environment,2019,646:1459-1467
• [7] Zahn D,Fromel T,Knepper T P. Halogenated methanesulfonic acids:A new class of organic micropollutants in the water cycle[J]. Water Research,2016,101:292-299
• [8] Gwenzi W,Mangori L,Danha C,et al. Sources,behaviour,and environmental and human health risks of hightechnology rare earth elements as emerging contaminants[J]. Science of the Total Environment,2018,636:299-313
• [9] Latala A,Nedzi M,Stepnowski P. Acute toxicity assessment of perfluorinated carboxylic acids towards the Baltic microalgae[J]. Environmental Toxicology and Pharmacology,2009,28(2):167-171
• [10] Xu D,Chen X,Shao B. Oxidative damage and cytotoxicity of perfluorooctane sulfonate on Chlorella vulgaris[J]. Bulletin of Environmental Contamination and Toxicology,2017,98(1):127-132
• [11] Ding G,Wouterse M,Baerselman R,et al. Toxicity of polyfluorinated and perfluorinated compounds to lettuce(Lactuca sativa)and green algae(Pseudokirchneriella subcapitata)[J]. Archives of Environmental Contamination and Toxicology,2012,62(1):49-55
• [12] Xu D,Li C,Chen H,et al. Cellular response of freshwater green algae to perfluorooctanoic acid toxicity[J].Ecotoxicology and Environmental Safety, 2013, 88:103-107
• [13] Liu W,Zhang Y B,Quan X,et al. Effect of perfluorooctane sulfonate on toxicity and cell uptake of other compounds with different hydrophobicity in green alga[J]. Chemosphere,2009,75(3):405-409
• [14] Boltes K,Rosal R,Garcia-Calvo E. Toxicity of mixtures of perfluorooctane sulphonic acid with chlorinated chemicals and lipid regulators[J]. Chemosphere,2012,86(1):24-29
• [15] Rosal R,Rodea-Palomares I,Boltes K,et al. Ecotoxicological assessment of surfactants in the aquatic environment:Combined toxicity of docusate sodium with chlorinated pollutants[J]. Chemosphere, 2010, 81(2):288-293
• [16] Boudreau T M,Sibley P K,Mabury S A,et al. Laboratory evaluation of the toxicity of perfluorooctane sulfonate(PFOS)on Selenastrum capricornutum,Chlorella vulgaris,Lemna gibba,Daphnia magna,and Daphnia pulicaria[J]. Archives of Environmental Contamination and Toxicology,2003,44(3):307-313
• [17]毕蓉．多环芳烃-蒽对两种海洋微藻的种群增长和种间竞争影响的研究[D]．青岛:中国海洋大学，2009:35-45Bi R. Effects of anthracene on the population growth and interspecific competition between two species of marine microalgae under controlled laboratory conditions[D].Qingdao:Ocean University of China,2009:35-45(in Chinese)
• [18]周立明，孟祥红，肖慧，等．3种多环芳烃和UV-B辐射对3种赤潮微藻生长的作用[J]．武汉大学学报:理学版，2006,52(6):773-777Zhou L M,Meng X H,Xiao H,et al. Interactive studies of three kinds of polycyclic aromatic hydrocarbons and UV-B radiation on the growth of three species of red tide microalgae[J]. Journal of Wuhan University:Natural Science Edition,2006,52(6):773-777(in Chinese)
• [19] Croxton A N,Wikfors G H,Schulterbrandt-Gragg R D.The use of flow cytometric applications to measure the effects of PAHs on growth,membrane integrity,and relative lipid content of the benthic diatom,Nitzschia brevirostris[J]. Marine Pollution Bulletin,2015,91(1):160-165
• [20]王亚，王仁君，孙晓伟，等．蒽和UV-B辐射对米氏凯伦藻生长的影响[J]．生物学通报，2009,44(12):44-46
• [21]洪有为，袁东星．典型多环芳烃对红树林区硅藻的毒性效应[J]．海洋环境科学，2008,27(4):338-342Hong Y W,Yuan D X. Toxic effect of typical polycyclic aromatics hydrocarbons on diatoms in mangrove area[J]. Marine Environmental Science,2008,27(4):338-342(in Chinese)
• [22] Lei A P,Hu Z L,Wong Y S,et al. Antioxidant responses of microalgal species to pyrene[J]. Journal of Applied Phycology,2006,18(1):67-78
• [23] Lei A P,Wong Y S,Tam N F Y. Removal of pyrene by different microalgal species[J]. Water Science and Technology,2002,46(11-12):195-201
• [24] Wang P,Luo L,Ke L,et al. Combined toxicity of polycyclic aromatic hydrocarbons and heavy metals to biochemical and antioxidant responses of free and immobilized Selenastrum capricornutum[J]. Environmental Toxicology and Chemistry,2013,32(3):673-683
• [25] Pérez P,Fernández E,Beiras R. Use of fast repetition rate fluorometry on detection and assessment of PAH toxicity on microalgae[J]. Water,Air,and Soil Pollution,2009,209(1-4):345-356
• [26]唐学玺，王明，张珺，等．多环芳烃在赤潮微藻光合作用中所起作用的研究[J]．中国海洋大学学报，2014,44(10):80-85Tang X X,Wang M,Zhang J,et al. Study on the effects of polycyclic aromatic hydrocarbons on the photosythesis in red tide microalgae[J]. Journal of Ocean University of China,2014,44(10):80-85(in Chinese)
• [27] Lei A P,Wong Y S,Tam N F. Pyrene-induced changes of glutathione-S-transferase activities in different microalgal species[J]. Chemosphere,2003,50:293-301
• [28] Ke L,Luo L,Wang P,et al. Effects of metals on biosorption and biodegradation of mixed polycyclic aromatic hydrocarbons by a freshwater green alga Selenastrum capricornutum[J]. Bioresource Technology,2010,101(18):6961-6972
• [29]贾汭婵．新月柱鞘藻对沉积物中多环芳烃的耐受性和修复作用[D]．天津:天津大学，2016:63-64Jia R C. Tolerance and remedial function of Cylindrotheca closterium to polycyclic aromatic hydrocarbons in sediments[D]. Tianjin:Tianjin University,2016:63-64(in Chinese)
• [30]丁艳萍．多环芳烃和表面活性剂及其联合毒性对青岛大扁藻的影响[D]．曲阜:曲阜师范大学，2012:25-30Ding Y P. The effect of PAHs and surfactants combined pollution system on the Platymonas helgolandica[D].Qufu:Qufu Normal University,2012:25-30(in Chinese)
• [31] Yu F,Ge F,Zhou W,et al. Subcellular distribution of fluoranthene in Chlorella vulgaris with the presence of cetyltrimethylammonium chloride[J]. Chemosphere,2013,90(3):929-935
• [32]黄健，韩德婷，唐学玺，等．多环芳烃对2种海洋微藻的联合毒性效应研究[J]．青岛海洋大学学报，2003,33(1):71-74Huang J,Han D T,Tang X X,et al. Study on the toxic coeffect of polycyclic aromatics hydrocarbons on two kinds of marine microalgae[J]. Journal of Ocean University of Qingdao,2003,33(1):71-74(in Chinese)
• [33] Melin C,Egneus H. Effects of di-n-butyl phthalate on growth and photosynthesis in algae and on isolated organelles from higher plants[J]. Physiologia Plantarum,1983,59(3):461-466
• [34]何瑞．邻苯二甲酸二丁酯对海洋微藻生长的影响及机制[D]．广州:暨南大学，2014:46He R. Effects and mechanisms of DBP on the growth of marine microalgae[D]. Guangzhou:Jinan University,2014:46(in Chinese)
• [35] Khalil N,Chen A,Lee M. Endocrine disruptive compounds and cardio-metabolic risk factors in children[J]. Current Opinion in Pharmacology,2014,19:120-124
• [36] Delorenzo M E,Fleming J. Individual and mixture effects of selected pharmaceuticals and personal care products on the marine phytoplankton species Dunaliella tertiolecta[J]. Archives of Environmental Contamination and Toxicology,2008,54(2):203-210
• [37] Jarvis A L,Bernot M J,Bernot R J. The effects of the psychiatric drug carbamazepine on freshwater invertebrate communities and ecosystem dynamics[J]. Science of the Total Environment,2014,496:461-470
• [38] Xin X,Huang G,Liu X,et al. Molecular toxicity of triclosan and carbamazepine to green algae Chlorococcum sp.:A single cell view using synchrotron-based Fourier transform infrared spectromicroscopy[J]. Environmental Pollution,2017,226:12-20
• [39]朱术超，刘滨扬，陈本亮，等．3种药物及个人护理品对斜生栅藻生长及光系统II的影响[J]．中山大学学报:自然科学版，2014,53(1):121-126Zhu S C,Liu B Y,Chen B L,et al. Effects of three pharmaceuticals and personal care products on growth and photosystemⅡin Scenedesmus obliquus[J]. Acta Scientiarum Naturalium Universitatis Sunyatseni,2014,53(1):121-126(in Chinese)
• [40] Pan X,Zhang D,Chen X,et al. Effects of levofloxacin hydrochloride on photosystemⅡactivity and heterogeneity of Synechocystis sp[J]. Chemosphere,2009,77(3):413-418
• [41] Tamura I,Yasuda Y,Kagota K I,et al. Contribution of pharmaceuticals and personal care products(PPCPs)to whole toxicity of water samples collected in effluent-dominated urban streams[J]. Ecotoxicology and Environmental Safety,2017,144:338-350
• [42] Harada A,Komori K,Nakada N,et al. Biological effects of PPCPs on aquatic lives and evaluation of river waters affected by different wastewater treatment levels[J]. Water Science and Technology,2008,58(8):1541-1546
• [43] Bácsi I,Deli J,Gonda S,et al. Non-steroidal anti-inflammatory drugs initiate morphological changes but inhibit carotenoid accumulation in Haematococcus pluvialis[J]. Algal Research,2018,31:1-13
• [44] Yamagishi T,Horie Y,Tatarazako N. Synergism between macrolide antibiotics and the azole fungicide ketoconazole in growth inhibition testing of the green alga Pseudokirchneriella subcapitata[J]. Chemosphere,2017,174:1-7
• [45] Petersen K,Heiaas H H,Tollefsen K E. Combined effects of pharmaceuticals,personal care products,biocides and organic contaminants on the growth of Skeletonema pseudocostatum[J]. Aquatic Toxicology,2014,150:45-54
• [46] Bi R,Zeng X,Mu L,et al. Sensitivities of seven algal species to triclosan,fluoxetine and their mixtures[J].Scientific Reports,2018,8(1):15361
• [47] Johnson D J,Sanderson H,Brain R A,et al. Toxicity and hazard of selective serotonin reuptake inhibitor antidepressants fluoxetine,fluvoxamine,and sertraline to algae[J]. Ecotoxicology and Environmental Safety,2007,67(1):128-139
• [48] Prata J C,Lavorante B,Montenegro B S M M,et al.Influence of microplastics on the toxicity of the pharmaceuticals procainamide and doxycycline on the marine microalgae Tetraselmis chuii[J]. Aquatic Toxicology,2018,197:143-152
• [49] Nie X P,Wang X,Chen J F,et al. Response of the freshwater alga Chlorella vulgaris to trichloroisocyanuric acid and ciprofloxacin[J]. Environmental Toxicology and Chemistry,2008,27(1):168-173
• [50] Halling-S?rensen B,Holten Lützh?ft H C,Andersen H R,et al. Environmental risk assessment of antibiotics:Comparison of mecillinam,trimethoprim and ciprofloxacin[J]. Antimicrobial Chemotherapy, 2000, 46(90001):53-58
• [51] Magdaleno A,Saenz M E,Juárez A B,et al. Effects of six antibiotics and their binary mixtures on growth of Pseudokirchneriella subcapitata[J]. Ecotoxicology and Environmental Safety,2015,113:72-78
• [52] Lützh?ft H C H,Halling-S?rensen B,J?rgensen S E.Algal toxicity of antibacterial agents applied in Danish fish farming[J]. Archives of Environmental Contamination and Toxicology,1999,36(1):1-6
• [53] Carusso S,Juarez A B,Moretton J,et al. Effects of three veterinary antibiotics and their binary mixtures on two green alga species[J]. Chemosphere,2018,194:821-827
• [54] Ando T,Nagase H,Eguchi K,et al. A novel method using cyanobacteria for ecotoxicity test of veterinary antimicobial agents[J]. Environmental Toxicology and Chemistry,2007,26(4):601-606
• [55] Andreozzi R,Canterino M,Giudice R L,et al. Lincomycin solar photodegradation,algal toxicity and removal from wastewaters by means of ozonation[J]. Water Research,2006,40(3):630-638
• [56] Halling-S?rensen B. Algal toxicity of antibacterial agents used in intensive farming[J]. Chemosphere,2000,40(7):731-739
• [57] Van der Grinten E,Pikkemaat M G,Van den Brandhof E J,et al. Comparing the sensitivity of algal,cyanobacterial and bacterial bioassays to different groups of antibiotics[J]. Chemosphere,2010,80(1):1-6
• [58] Lanzky P F,Halling-S?rensen B. The toxic effect of the antibiotic metronidazole on aquatic organisms[J].Chemosphere,1997,35(11):2553-2561
• [59]李义刚．三氯生、布洛芬和氯化镉对羊角月牙藻的毒性效应[D]．广州:暨南大学，2013:64Li Y G. Toxic effects of triclosan,ibuprofen and cadmium chloride to Selenastrum capricornutum[D]. Guangzhou:Jinan University,2013:64(in Chinese)
• [60] Zhang W,Zhang M,Lin K,et al. Eco-toxicological effect of carbamazepine on Scenedesmus obliquus and Chlorella pyrenoidosa[J]. Environmental Toxicology and Pharmacology,2012,33(2):344-352
• [61] Yang W,Tang Z,Zhou F,et al. Toxicity studies of tetracycline on Microcystis aeruginosa and Selenastrum capricornutum[J]. Environmental Toxicology and Pharmacology,2013,35(2):320-324
• [62] Nie X P,Liu B Y,Yu H J,et al. Toxic effects of erythromycin,ciprofloxacin and sulfamethoxazole exposure to the antioxidant system in Pseudokirchneriella subcapitata[J]. Environmental Pollution,2013,172:23-32
• [63] Liu B Y,Nie X P,Liu W Q,et al. Toxic effects of erythromycin,ciprofloxacin and sulfamethoxazole on photosynthetic apparatus in Selenastrum capricornutum[J].Ecotoxicology and Environmental Safety,2011,74(4):1027-1035
• [64] Xiong J Q,Kurade M B,Jeon B H. Can microalgae remove pharmaceutical contaminants from water?[J].Trends in Biotechnology,2018,36(1):30-44
• [65] Bai X,Acharya K. Removal of trimethoprim,sulfamethoxazole,and triclosan by the green alga Nannochloris sp[J]. Journal of Hazardous Materials,2016,315:70-75
• [66] Liu Y,Guan Y,Gao Q,et al. Cellular responses,biodegradation and bioaccumulation of endocrine disrupting chemicals in marine diatom Navicula incerta[J]. Chemosphere,2010,80(5):592-599
• [67] Ding T,Lin K,Yang M,et al. Biodegradation of triclosan in diatom Navicula sp.:Kinetics,transformation products,toxicity evaluation and the effects of p H and potassium permanganate[J]. Journal of Hazardous Materials,2018,344:200-209
• [68] Norvill Z N,Shilton A,Guieysse B. Emerging contaminant degradation and removal in algal wastewater treatment ponds:Identifying the research gaps[J]. Journal of Hazardous Materials,2016,313:291-309
• [69] Ji M K,Kabra A N,Choi J,et al. Biodegradation of bisphenol A by the freshwater microalgae Chlamydomonas mexicana and Chlorella vulgaris[J]. Ecological Engineering,2014,73:260-269
• [70] Wang S,Poon K,Cai Z. Removal and metabolism of triclosan by three different microalgal species in aquatic environment[J]. Journal of Hazardous Materials,2018,342:643-650
• [71] Liu Y,Zhang J,Gao B,et al. Combined effects of two antibiotic contaminants on Microcystis aeruginosa[J].Journal of Hazardous Materials,2014,279:148-155
• [72]郐安琪，赵伟华，李青云，等．典型污染物对藻类生态毒性效应研究进展[J]．长江科学院院报，2015,32(6):100-109Kuai A Q,Zhao W H,Li Q Y,et al. Research advances in ecotoxicological effects of typical pollutants on algae[J]. Journal of Yangtze River Scientific Research Institute,2015,32(6):100-109(in Chinese)
• [73] Peralta-Videa J R,Zhao L,Lopez-Moreno M L,et al.Nanomaterials and the environment:A review for the biennium 2008-2010[J]. Journal of Hazardous Materials,2011,186(1):1-15
• [74] Adams L K,Lyon D Y,Alvarez P J. Comparative ecotoxicity of nanoscale Ti O2,Si O2,and Zn O water suspensions[J]. Water Research,2006,40(19):3527-3532
• [75] Nel A. Toxic potential of materials at the nanolevel[J].Science,2006,311(5761):622-627
• [76] Ahmad F,Yao H,Zhou Y,et al. Toxicity of cobalt ferrite(Co Fe2O4)nanobeads in Chlorella vulgaris:Interaction,adaptation and oxidative stress[J]. Chemosphere,2015,139:479-485
• [77] Chae Y,An Y J. Toxicity and transfer of polyvinylpyrrolidone-coated silver nanowires in an aquatic food chain consisting of algae,water fleas,and zebrafish[J]. Aquatic Toxicology,2016,173:94-104
• [78] Sendra M,Yeste M P,Gatica J M,et al. Direct and indirect effects of silver nanoparticles on freshwater and marine microalgae(Chlamydomonas reinhardtii and Phaeodactylum tricornutum)[J]. Chemosphere,2017,179:279-289
• [79] Oukarroum A,Bras S,Perreault F,et al. Inhibitory effects of silver nanoparticles in two green algae,Chlorella vulgaris and Dunaliella tertiolecta[J]. Ecotoxicology and Environmental Safety,2012,78:80-85
• [80] Klaine S J,Alvarez P J J,Batley G E,et al. Nanomaterials in the environment:Behavior,fate,bioavailability,and effects[J]. Environmental Toxicology and Chemistry,2008,27(9):1825-1851
• [81] Bhattacharya P,Lin S,Turner J P,et al. Physical adsorption of charged plastic nanoparticles affects algal photosynthesis[J]. The Journal of Physical Chemistry C,2010,114(39):16556-16561
• [82] Wei L,Thakkar M,Chen Y,et al. Cytotoxicity effects of water dispersible oxidized multiwalled carbon nanotubes on marine alga,Dunaliella tertiolecta[J]. Aquatic Toxicology,2010,100(2):194-201
• [83] Chen L,Zhou L,Liu Y,et al. Toxicological effects of nanometer titanium dioxide(nano-TiO2)on Chlamydomonas reinhardtii[J]. Ecotoxicology and Environmental Safety,2012,84:155-162
• [84] Zhao J,Cao X,Wang Z,et al. Mechanistic understanding toward the toxicity of graphene-family materials to freshwater algae[J]. Water Research,2017,111:18-27
• [85] Gong N,Shao K,Feng W,et al. Biotoxicity of nickel oxide nanoparticles and bio-remediation by microalgae Chlorella vulgaris[J]. Chemosphere,2011,83(4):510-516
• [86] Wang Z,Li J,Zhao J,et al. Toxicity and internalization of Cu O nanoparticles to prokaryotic alga Microcystis aeruginosa as affected by dissolved organic matter[J].Environmental Science and Technology,2011,45(14):6032-6040
• [87] Wang J,Zhang X,Chen Y,et al. Toxicity assessment of manufactured nanomaterials using the unicellular green alga Chlamydomonas reinhardtii[J]. Chemosphere,2008,73(7):1121-1128
• [88] Schiavo S,Oliviero M,Miglietta M,et al. Genotoxic and cytotoxic effects of Zn O nanoparticles for Dunaliella tertiolecta and comparison with Si O2and Ti O2effects at population growth inhibition levels[J]. Science of the Total Environment,2016,550:619-627
• [89]程艳红，陈金媛，李何荣，等．纳米材料的水生毒性研究进展[J]．环境与健康杂志，2014,31(4):371-376Cheng Y H,Chen J Y,Li H R,et al. Aquatic toxicity of nanomaterials:A review of recent studies[J]. Journal of Environment and Health,2014,31(4):371-376(in Chinese)
• [90] Jambeck J R,Geyer R,Wilcox C,et al. Plastic waste inputs from land into the ocean[J]. Science,2015,347(6223):768-771
• [91] Zhang C,Chen X,Wang J,et al. Toxic effects of microplastic on marine microalgae Skeletonema costatum:Interactions between microplastic and algae[J]. Environmental Pollution,2017,220(Pt B):1282-1288
• [92] Long M,Paul-Pont I,Hegaret H,et al. Interactions between polystyrene microplastics and marine phytoplankton lead to species-specific hetero-aggregation[J]. Environmental Pollution,2017,228:454-463
• [93] Mao Y,Ai H,Chen Y,et al. Phytoplankton response to polystyrene microplastics:Perspective from an entire growth period[J]. Chemosphere,2018,208:59-68
• [94] Sjollema S B,Redondo-Hasselerharm P,Leslie H A,et al. Do plastic particles affect microalgal photosynthesis and growth?[J]. Aquatic Toxicology,2016,170:259-261
• [95] Besseling E,Wang B,Lurling M,et al. Nanoplastic affects growth of S. obliquus and reproduction of D. magna[J]. Environmental Science and Technology,2014,48(20):12336-12343
• [96] Lagarde F,Olivier O,Zanella M,et al. Microplastic interactions with freshwater microalgae:Hetero-aggregation and changes in plastic density appear strongly dependent on polymer type[J]. Environmental Pollution,2016,215:331-339
• [97] Davarpanah E,Guilhermino L. Single and combined effects of microplastics and copper on the population growth of the marine microalgae Tetraselmis chuii[J].Estuarine,Coastal and Shelf Science,2015,167:269-275
• [98] Nakajima N,Teramoto T,Kasai F,et al. Glycosylation of bisphenol A by freshwater microalgae[J]. Chemosphere,2007,69(6):934-941
• [99] Goecke F,Vítova'M,Lukavsky'J,et al. Effects of rare earth elements on growth rate,lipids,fatty acids and pigments in microalgae[J]. Phycological Research,2017,65(3):226-234
• [100] Tai P,Zhao Q,Su D,et al. Biological toxicity of lanthanide elements on algae[J]. Chemosphere,2010,80(9):1031-1035
• [101] Gonzalez V,Vignati D A,Pons M N,et al. Lanthanide ecotoxicity:First attempt to measure environmental risk for aquatic organisms