郑智新;胡继业;

• 1:北京科技大学化学与生物工程学院

摘要(Abstract)：

应用彗星实验检测了新农药呋喃虫酰肼(JS-118)对小鼠脾细胞和睾丸细胞的DNA损伤,并比较了这两种细胞对呋喃虫酰肼的敏感性.体外染毒1.5h后,进行单细胞凝胶电泳,然后EB染色并用CASP分析图像.结果表明,呋喃虫酰肼在各个剂量浓度(100、200、500、1000mg·L-1)都会引起睾丸细胞DNA损伤(与对照组均具有显着性差异,p<0.05),且存在明显的剂量-效应关系;而呋喃虫酰肼在较高剂量浓度(200、500、1000mg·L-1)可引起脾细胞DNA损伤(与对照组均具有显着性差异,p<0.05),且存在明显的剂量-效应关系.与脾细胞相比,睾丸细胞对呋喃虫酰肼更为敏感.

关键词(KeyWords)： 呋喃虫酰肼;彗星实验;脾细胞;睾丸细胞;DNA损伤

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(No.20777078)

作者(Author): 郑智新;胡继业;

Email:

DOI:

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