庄娟;李梦秋;洪法水;胡卫成;张萌萌;周颖君;罗艳;张建梅;郑元林;

• 1:淮阴师范学院生命科学学院江苏省环洪泽湖生态农业生物技术重点实验室淮阴师范学院江苏省高校区域现代农业与环境保护协同创新中心
• 2:江苏师范大学江苏省药用植物生物技术重点实验室江苏师范大学生命科学学院

摘要(Abstract)：

为探讨持久性有机污染物2,2’,4,4’-四溴联苯醚(BDE-47)对小鼠海马组织的神经毒性,将小鼠每日灌胃25或50 mg·kg-1剂量的BDE-47,6周后检测其记忆能力、海马组织病理学变化、蛋白激酶C(PKC)表达量和半胱氨酸天冬氨酸蛋白酶-3(caspase-3)活性。结果显示,BDE-47损伤了小鼠被动回避实验的记忆保持能力,导致海马安蒙角(CA1)区锥体细胞排列紊乱,神经元胞体体积变小,形态不规则。BDE-47对小鼠海马组织PKCα、β、γ和ζ的表达无影响,但显著上调了PKCδ和PKCλ的表达,促进了caspase-3活性。这些结果提示,BDE-47导致的海马神经毒性可能与PKCδ和PKCλ表达异常及caspase-3活性升高有关。本实验结果为进一步了解BDE-47神经毒作用机制提供了实验依据。

关键词(KeyWords)： BDE-47;海马组织;神经毒性;PKC;caspase-3

Abstract:

Keywords:

基金项目(Foundation): 江苏高校品牌专业建设工程资助项目(PPZY2015A018);; 国家自然科学基金(NO:81571055,31671033,31600281);; 江苏省高校自然科学基金(NO:18KJB330001)

作者(Author): 庄娟;李梦秋;洪法水;胡卫成;张萌萌;周颖君;罗艳;张建梅;郑元林;

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DOI:

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